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Increases in renal angiotensin II content and tubular angiotensin II receptors in prehypertensive spontaneously hypertensive rats.
J Hypertens. 1988 Oct; 6(10):791-6.JH

Abstract

To examine the role of the intrarenal renin-angiotensin system in the development of hypertension in spontaneously hypertensive rats (SHR), we measured angiotensin II contents and tubular 125I-angiotensin II binding sites in the kidney of SHR and age-matched Wistar-Kyoto rats (WKY). In prehypertensive (4-week-old) SHR, not only the kidney angiotensin II content but also the angiotensin II receptor density in brush border membranes were significantly higher than in the WKY. In contrast, angiotensin II levels in the 20-week-old SHR kidneys were significantly lower than in the WKY. Acceleration of the intrarenal renin-angiotensin system and the increased density of tubular angiotensin II receptors in young SHR may therefore play an important role in the development of high blood pressure in SHR.

Authors+Show Affiliations

Department of Cardiovascular Dynamics, National Cardiovascular/Center Research Institute, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3198916

Citation

Matsushima, Y, et al. "Increases in Renal Angiotensin II Content and Tubular Angiotensin II Receptors in Prehypertensive Spontaneously Hypertensive Rats." Journal of Hypertension, vol. 6, no. 10, 1988, pp. 791-6.
Matsushima Y, Kawamura M, Akabane S, et al. Increases in renal angiotensin II content and tubular angiotensin II receptors in prehypertensive spontaneously hypertensive rats. J Hypertens. 1988;6(10):791-6.
Matsushima, Y., Kawamura, M., Akabane, S., Imanishi, M., Kuramochi, M., Ito, K., & Omae, T. (1988). Increases in renal angiotensin II content and tubular angiotensin II receptors in prehypertensive spontaneously hypertensive rats. Journal of Hypertension, 6(10), 791-6.
Matsushima Y, et al. Increases in Renal Angiotensin II Content and Tubular Angiotensin II Receptors in Prehypertensive Spontaneously Hypertensive Rats. J Hypertens. 1988;6(10):791-6. PubMed PMID: 3198916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increases in renal angiotensin II content and tubular angiotensin II receptors in prehypertensive spontaneously hypertensive rats. AU - Matsushima,Y, AU - Kawamura,M, AU - Akabane,S, AU - Imanishi,M, AU - Kuramochi,M, AU - Ito,K, AU - Omae,T, PY - 1988/10/1/pubmed PY - 1988/10/1/medline PY - 1988/10/1/entrez SP - 791 EP - 6 JF - Journal of hypertension JO - J. Hypertens. VL - 6 IS - 10 N2 - To examine the role of the intrarenal renin-angiotensin system in the development of hypertension in spontaneously hypertensive rats (SHR), we measured angiotensin II contents and tubular 125I-angiotensin II binding sites in the kidney of SHR and age-matched Wistar-Kyoto rats (WKY). In prehypertensive (4-week-old) SHR, not only the kidney angiotensin II content but also the angiotensin II receptor density in brush border membranes were significantly higher than in the WKY. In contrast, angiotensin II levels in the 20-week-old SHR kidneys were significantly lower than in the WKY. Acceleration of the intrarenal renin-angiotensin system and the increased density of tubular angiotensin II receptors in young SHR may therefore play an important role in the development of high blood pressure in SHR. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/3198916/Increases_in_renal_angiotensin_II_content_and_tubular_angiotensin_II_receptors_in_prehypertensive_spontaneously_hypertensive_rats_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3198916.ui DB - PRIME DP - Unbound Medicine ER -