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Comprehensive genetic structure analysis of Han population from Dalian City revealed by 20 Y-STRs.
Mol Genet Genomic Med. 2020 03; 8(3):e1149.MG

Abstract

BACKGROUND

Dalian is a city formed in the 1880s in Liaoning province, Northeastern China with a population of 6.69 million now. Han is the largest ethnic group not only across Mainland China (92%) and Taiwan (97%) but also considered to be the largest ethnic group of the world contributing to above 18% of world's population.

METHODS

In the current study, we genotyped Goldeneye® 20Y System loci in 879 unrelated male individuals from the Han ethnic group in Dalian city and calculated the forensic parameters of the 20 Y-STR loci.

RESULTS

In total, we observed 855 haplotypes, among which 835 (94.99%) were unique. The discrimination capacity (DC) of overall Goldeneye® 20Y System is 97.27% and it slightly reduces to 96.93% when only Y-filer® set of 17 Y-STRs were used, which mitigates using the extended set of markers in this population. We found DYS388 showed the lowest gene diversity (0.5151), whereas DYS389II showed the highest gene diversity (0.7621) in single copy Y-STR, and DYS385 showed the highest gene diversity (0.9683) among all.

CONCLUSION

Multidimensional scaling (MDS) analysis based upon pairwise Rst genetic distance showed difference among Han population from the east to the west and from the north to the south. We also predicted haplogroups using Y-STR haplotypes, which showed the dominance of Haplogroup O (65.2%) followed by Haplogroup C (14.5%) in Dalian Han population. Moreover, we found 10 individuals showed a null allele at the DYS448 in our samples. We also performed linear discriminatory analysis (LDA) between Han and other prominent Chinese minority ethnic groups. We presented Y-STRs data in the Y-Chromosome Haplotype Reference Database (YHRD) for the future forensic and other usage.

Links

PMC Free PDF

Authors+Show Affiliations

Adnan A
Department of Forensic Genetics and Biology, School of Forensic Medicine, China Medical University, Shenyang, P.R. China. Department of Human Anatomy, College of Basic Medical Science, China Medical University, Shenyang, P.R. China.
Kasimu K
School of Clinical Medicine, China Medical University, Shenyang, P.R. China.
Rakha A
Department of Forensic Sciences, University of Health Sciences Lahore, Lahore, Pakistan.
He G
Department of Anthropology and Ethnology, Xiamen University, Xiamen, China.
Yang T
Department of Human Anatomy, College of Basic Medical Science, China Medical University, Shenyang, P.R. China.
Wang CC
Department of Anthropology and Ethnology, Xiamen University, Xiamen, China.
Lu J
Department of Human Anatomy, College of Basic Medical Science, China Medical University, Shenyang, P.R. China.
Xuan JF
Department of Forensic Genetics and Biology, School of Forensic Medicine, China Medical University, Shenyang, P.R. China.

MeSH

ChinaChromosomes, Human, YHaplotypesHumansMaleMicrosatellite RepeatsPolymorphism, GeneticPopulation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31989793

Citation

Adnan, Atif, et al. "Comprehensive Genetic Structure Analysis of Han Population From Dalian City Revealed By 20 Y-STRs." Molecular Genetics & Genomic Medicine, vol. 8, no. 3, 2020, pp. e1149.
Adnan A, Kasimu K, Rakha A, et al. Comprehensive genetic structure analysis of Han population from Dalian City revealed by 20 Y-STRs. Mol Genet Genomic Med. 2020;8(3):e1149.
Adnan, A., Kasimu, K., Rakha, A., He, G., Yang, T., Wang, C. C., Lu, J., & Xuan, J. F. (2020). Comprehensive genetic structure analysis of Han population from Dalian City revealed by 20 Y-STRs. Molecular Genetics & Genomic Medicine, 8(3), e1149. https://doi.org/10.1002/mgg3.1149
Adnan A, et al. Comprehensive Genetic Structure Analysis of Han Population From Dalian City Revealed By 20 Y-STRs. Mol Genet Genomic Med. 2020;8(3):e1149. PubMed PMID: 31989793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comprehensive genetic structure analysis of Han population from Dalian City revealed by 20 Y-STRs. AU - Adnan,Atif, AU - Kasimu,Kaidirina, AU - Rakha,Allah, AU - He,Guanglin, AU - Yang,Tongya, AU - Wang,Chuan-Chao, AU - Lu,Jie, AU - Xuan,Jin-Feng, Y1 - 2020/01/27/ PY - 2019/09/10/received PY - 2019/11/15/revised PY - 2020/01/08/accepted PY - 2020/1/29/pubmed PY - 2021/3/30/medline PY - 2020/1/29/entrez KW - Dalian KW - Han KW - O haplogroup KW - Y-Chromosome Haplotype Reference Database (YHRD) KW - Y-STRs KW - forensic genetics SP - e1149 EP - e1149 JF - Molecular genetics & genomic medicine JO - Mol Genet Genomic Med VL - 8 IS - 3 N2 - BACKGROUND: Dalian is a city formed in the 1880s in Liaoning province, Northeastern China with a population of 6.69 million now. Han is the largest ethnic group not only across Mainland China (92%) and Taiwan (97%) but also considered to be the largest ethnic group of the world contributing to above 18% of world's population. METHODS: In the current study, we genotyped Goldeneye® 20Y System loci in 879 unrelated male individuals from the Han ethnic group in Dalian city and calculated the forensic parameters of the 20 Y-STR loci. RESULTS: In total, we observed 855 haplotypes, among which 835 (94.99%) were unique. The discrimination capacity (DC) of overall Goldeneye® 20Y System is 97.27% and it slightly reduces to 96.93% when only Y-filer® set of 17 Y-STRs were used, which mitigates using the extended set of markers in this population. We found DYS388 showed the lowest gene diversity (0.5151), whereas DYS389II showed the highest gene diversity (0.7621) in single copy Y-STR, and DYS385 showed the highest gene diversity (0.9683) among all. CONCLUSION: Multidimensional scaling (MDS) analysis based upon pairwise Rst genetic distance showed difference among Han population from the east to the west and from the north to the south. We also predicted haplogroups using Y-STR haplotypes, which showed the dominance of Haplogroup O (65.2%) followed by Haplogroup C (14.5%) in Dalian Han population. Moreover, we found 10 individuals showed a null allele at the DYS448 in our samples. We also performed linear discriminatory analysis (LDA) between Han and other prominent Chinese minority ethnic groups. We presented Y-STRs data in the Y-Chromosome Haplotype Reference Database (YHRD) for the future forensic and other usage. SN - 2324-9269 UR - https://www.unboundmedicine.com/medline/citation/31989793/Comprehensive_genetic_structure_analysis_of_Han_population_from_Dalian_City_revealed_by_20_Y_STRs_ DB - PRIME DP - Unbound Medicine ER -