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[Evidence-based treatment of acute psychotic episode and schizophrenia in children and adolescents].
Zh Nevrol Psikhiatr Im S S Korsakova. 2019; 119(12):132-138.ZN

Abstract

Children and adolescents are a special group in the context of psychopharmacotherapy. Given the limited choice of registered antipsychotics permitted in childhood, caution should be exercised in the choice of medication. This literature review reviews the current evidence base for pharmacotherapy of acute psychotic episode and schizophrenia in children and adolescents. The results of major systematic reviews and meta-analyses are compared. Meta-analyses of pharmacotherapy studies of the first psychotic episode are considered separately. Antipsychotics of the first and second generation are comparable in effectiveness for children and adolescents with acute psychotic episode. Olanzapine demonstrates higher efficacy in reducing negative symptoms. Ziprasidone and asenapine are less effective in treating schizophrenia in children and adolescents than other antipsychotics. Compared to adults, children and adolescents are at higher risk of metabolic impairments when taking antipsychotics.

Authors+Show Affiliations

Russian Medical Academy for Continuing Professional Education, Moscow, Russia.Sukhareva Research Practical Center of Children and Adolescents Mental Health, Moscow, Russia.Russian Medical Academy for Continuing Professional Education, Moscow, Russia.Sukhareva Research Practical Center of Children and Adolescents Mental Health, Moscow, Russia.Russian Medical Academy for Continuing Professional Education, Moscow, Russia.Russian Medical Academy for Continuing Professional Education, Moscow, Russia.Russian Medical Academy for Continuing Professional Education, Moscow, Russia.

Pub Type(s)

Journal Article
Review

Language

rus

PubMed ID

31994526

Citation

Ivashchenko, D V., et al. "[Evidence-based Treatment of Acute Psychotic Episode and Schizophrenia in Children and Adolescents]." Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova, vol. 119, no. 12, 2019, pp. 132-138.
Ivashchenko DV, Buromskaya NI, Tazagulova MK, et al. [Evidence-based treatment of acute psychotic episode and schizophrenia in children and adolescents]. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(12):132-138.
Ivashchenko, D. V., Buromskaya, N. I., Tazagulova, M. K., Tutova, A. D., Savchenko, L. M., Shevchenko, Y. S., & Sychev, D. A. (2019). [Evidence-based treatment of acute psychotic episode and schizophrenia in children and adolescents]. Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova, 119(12), 132-138. https://doi.org/10.17116/jnevro2019119121132
Ivashchenko DV, et al. [Evidence-based Treatment of Acute Psychotic Episode and Schizophrenia in Children and Adolescents]. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(12):132-138. PubMed PMID: 31994526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Evidence-based treatment of acute psychotic episode and schizophrenia in children and adolescents]. AU - Ivashchenko,D V, AU - Buromskaya,N I, AU - Tazagulova,M Kh, AU - Tutova,A D, AU - Savchenko,L M, AU - Shevchenko,Yu S, AU - Sychev,D A, PY - 2020/1/30/entrez PY - 2020/1/30/pubmed PY - 2020/2/1/medline KW - acute psychotic episode KW - antipsychotics KW - children and adolescents KW - early-onset schizophrenia KW - effectiveness SP - 132 EP - 138 JF - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova JO - Zh Nevrol Psikhiatr Im S S Korsakova VL - 119 IS - 12 N2 - Children and adolescents are a special group in the context of psychopharmacotherapy. Given the limited choice of registered antipsychotics permitted in childhood, caution should be exercised in the choice of medication. This literature review reviews the current evidence base for pharmacotherapy of acute psychotic episode and schizophrenia in children and adolescents. The results of major systematic reviews and meta-analyses are compared. Meta-analyses of pharmacotherapy studies of the first psychotic episode are considered separately. Antipsychotics of the first and second generation are comparable in effectiveness for children and adolescents with acute psychotic episode. Olanzapine demonstrates higher efficacy in reducing negative symptoms. Ziprasidone and asenapine are less effective in treating schizophrenia in children and adolescents than other antipsychotics. Compared to adults, children and adolescents are at higher risk of metabolic impairments when taking antipsychotics. SN - 1997-7298 UR - https://www.unboundmedicine.com/medline/citation/31994526/[Evidence-based_treatment_of_acute_psychotic_episode_and_schizophrenia_in_children_and_adolescents] L2 - http://www.diseaseinfosearch.org/result/6442 DB - PRIME DP - Unbound Medicine ER -