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Potential of large "first generation" human-to-human transmission of 2019-nCoV.
J Med Virol. 2020 04; 92(4):448-454.JM

Abstract

To investigate the genetic diversity, time origin, and evolutionary history of the 2019-nCoV outbreak in China and Thailand, a total of 12 genome sequences of the virus with known sampling date (24 December 2019 and 13 January 2020) and geographic location (primarily Wuhan city, Hubei Province, China, but also Bangkok, Thailand) were analyzed. Phylogenetic and likelihood-mapping analyses of these genome sequences were performed. On the basis of our results, the star-like signal and topology of 2019-nCoV may be indicative of potentially large "first generation" human-to-human virus transmission. We estimated that 2019-nCoV likely originated in Wuhan on 9 November 2019 (95% credible interval: 25 September 2019 and 19 December 2019), and that Wuhan is the major hub for the spread of the 2019-nCoV outbreak in China and elsewhere. Our results could be useful for designing effective prevention strategies for 2019-nCoV in China and beyond.

Authors+Show Affiliations

Hubei Engineering Research Center of Viral Vector, Wuhan University of Bioengineering, Wuhan, China.Immunology Innovation Team, School of Medicine, Ningbo University, Ningbo, China.Hubei Engineering Research Center of Viral Vector, Wuhan University of Bioengineering, Wuhan, China.Hubei Engineering Research Center of Viral Vector, Wuhan University of Bioengineering, Wuhan, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Comment

Language

eng

PubMed ID

31997390

Citation

Li, Xingguang, et al. "Potential of Large "first Generation" Human-to-human Transmission of 2019-nCoV." Journal of Medical Virology, vol. 92, no. 4, 2020, pp. 448-454.
Li X, Zai J, Wang X, et al. Potential of large "first generation" human-to-human transmission of 2019-nCoV. J Med Virol. 2020;92(4):448-454.
Li, X., Zai, J., Wang, X., & Li, Y. (2020). Potential of large "first generation" human-to-human transmission of 2019-nCoV. Journal of Medical Virology, 92(4), 448-454. https://doi.org/10.1002/jmv.25693
Li X, et al. Potential of Large "first Generation" Human-to-human Transmission of 2019-nCoV. J Med Virol. 2020;92(4):448-454. PubMed PMID: 31997390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential of large "first generation" human-to-human transmission of 2019-nCoV. AU - Li,Xingguang, AU - Zai,Junjie, AU - Wang,Xiaomei, AU - Li,Yi, Y1 - 2020/02/14/ PY - 2020/01/24/received PY - 2020/01/27/accepted PY - 2020/1/31/pubmed PY - 2020/3/18/medline PY - 2020/1/31/entrez KW - 2019-nCoV KW - Bangkok KW - TMRCA KW - Wuhan KW - outbreak SP - 448 EP - 454 JF - Journal of medical virology JO - J. Med. Virol. VL - 92 IS - 4 N2 - To investigate the genetic diversity, time origin, and evolutionary history of the 2019-nCoV outbreak in China and Thailand, a total of 12 genome sequences of the virus with known sampling date (24 December 2019 and 13 January 2020) and geographic location (primarily Wuhan city, Hubei Province, China, but also Bangkok, Thailand) were analyzed. Phylogenetic and likelihood-mapping analyses of these genome sequences were performed. On the basis of our results, the star-like signal and topology of 2019-nCoV may be indicative of potentially large "first generation" human-to-human virus transmission. We estimated that 2019-nCoV likely originated in Wuhan on 9 November 2019 (95% credible interval: 25 September 2019 and 19 December 2019), and that Wuhan is the major hub for the spread of the 2019-nCoV outbreak in China and elsewhere. Our results could be useful for designing effective prevention strategies for 2019-nCoV in China and beyond. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/31997390/Potential_of_large_"first_generation"_human_to_human_transmission_of_2019_nCoV_ L2 - https://doi.org/10.1002/jmv.25693 DB - PRIME DP - Unbound Medicine ER -