Tags

Type your tag names separated by a space and hit enter

Three-dimensional vocal fold structural change due to implant insertion in medialization laryngoplasty.
PLoS One. 2020; 15(1):e0228464.Plos

Abstract

Glottal insufficiency due to vocal fold paralysis, paresis, or atrophy often leads to degraded voice quality. One of the primary surgical intervention procedures to treat glottal insufficiency is medialization laryngoplasty, in which an implant is inserted through a lateral window on the thyroid cartilage to medialize the vocal folds. While the goal of medialization is to modify the vocal fold structure to restore normal phonation, few studies have attempted to quantify such structural changes of the vocal folds. The goal of this study is to quantify the three-dimensional structural changes of the vocal folds due to implant insertion in medialization laryngoplasty, and evaluate its potential effect on voice production. Medialization laryngoplasty were performed in excised human larynges using implants of different stiffness. Magnetic resonance images of the larynges were obtained with and without implant insertion. The results showed that implant insertion significantly changed the original body-cover structure of the vocal folds, with the implant taking over the large space used to be occupied by the original body layer and the vocal fold being stretched into a thin layer wrapped around the implant. The medial-lateral dimension of the vocal fold was significantly reduced from about 4 mm to 1 mm, and the vocal fold was stretched in the coronal plane by about 70%. It is hypothesized that use of implants with stiffness comparable to that of the vocal folds is beneficial because the degree of medialization can be adjusted without much negative effects on phonation frequency, phonation threshold pressure, or vibration amplitude.

Authors+Show Affiliations

Department of Head and Neck Surgery, University of California, Los Angeles, California, United States of America.Department of Head and Neck Surgery, University of California, Los Angeles, California, United States of America.Department of Head and Neck Surgery, University of California, Los Angeles, California, United States of America.Department of Head and Neck Surgery, University of California, Los Angeles, California, United States of America.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31999758

Citation

Zhang, Zhaoyan, et al. "Three-dimensional Vocal Fold Structural Change Due to Implant Insertion in Medialization Laryngoplasty." PloS One, vol. 15, no. 1, 2020, pp. e0228464.
Zhang Z, Wu L, Gray R, et al. Three-dimensional vocal fold structural change due to implant insertion in medialization laryngoplasty. PLoS ONE. 2020;15(1):e0228464.
Zhang, Z., Wu, L., Gray, R., & Chhetri, D. K. (2020). Three-dimensional vocal fold structural change due to implant insertion in medialization laryngoplasty. PloS One, 15(1), e0228464. https://doi.org/10.1371/journal.pone.0228464
Zhang Z, et al. Three-dimensional Vocal Fold Structural Change Due to Implant Insertion in Medialization Laryngoplasty. PLoS ONE. 2020;15(1):e0228464. PubMed PMID: 31999758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-dimensional vocal fold structural change due to implant insertion in medialization laryngoplasty. AU - Zhang,Zhaoyan, AU - Wu,Liang, AU - Gray,Raluca, AU - Chhetri,Dinesh K, Y1 - 2020/01/30/ PY - 2019/10/10/received PY - 2020/01/16/accepted PY - 2020/1/31/entrez PY - 2020/1/31/pubmed PY - 2020/4/21/medline SP - e0228464 EP - e0228464 JF - PloS one JO - PLoS ONE VL - 15 IS - 1 N2 - Glottal insufficiency due to vocal fold paralysis, paresis, or atrophy often leads to degraded voice quality. One of the primary surgical intervention procedures to treat glottal insufficiency is medialization laryngoplasty, in which an implant is inserted through a lateral window on the thyroid cartilage to medialize the vocal folds. While the goal of medialization is to modify the vocal fold structure to restore normal phonation, few studies have attempted to quantify such structural changes of the vocal folds. The goal of this study is to quantify the three-dimensional structural changes of the vocal folds due to implant insertion in medialization laryngoplasty, and evaluate its potential effect on voice production. Medialization laryngoplasty were performed in excised human larynges using implants of different stiffness. Magnetic resonance images of the larynges were obtained with and without implant insertion. The results showed that implant insertion significantly changed the original body-cover structure of the vocal folds, with the implant taking over the large space used to be occupied by the original body layer and the vocal fold being stretched into a thin layer wrapped around the implant. The medial-lateral dimension of the vocal fold was significantly reduced from about 4 mm to 1 mm, and the vocal fold was stretched in the coronal plane by about 70%. It is hypothesized that use of implants with stiffness comparable to that of the vocal folds is beneficial because the degree of medialization can be adjusted without much negative effects on phonation frequency, phonation threshold pressure, or vibration amplitude. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/31999758/Three-dimensional_vocal_fold_structural_change_due_to_implant_insertion_in_medialization_laryngoplasty L2 - http://dx.plos.org/10.1371/journal.pone.0228464 DB - PRIME DP - Unbound Medicine ER -