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Advances in the diagnosis and treatment of dry eye.
Prog Retin Eye Res. 2020 Jan 29 [Online ahead of print]PR

Abstract

The core mechanism of dry eye is the tear film instability. Tear film-oriented diagnosis (TFOD) is a concept to clarify the cause of tear film instability by tear film, and tear film-oriented treatment (TFOT) is a concept to treat dry eye disease by replacing the lacking components of the tear film layer based on the TFOD. In TFOD, the fluorescein breakup pattern of the tear film is important, and the subtype of dry eye can be judged to some extent from the breakup patterns. Current noninvasive devices related to the dynamic analysis of the tear film and visual acuity enabled the diagnosis of dry eye, subtype analysis, and the extent of severity. In Asian countries, secretagogues represent the main treatment in TFOT. Since meibomian gland dysfunction is a factor that greatly affects the tear breakup time, its treatment is also essential in the dry eye treatment strategy. A newly discovered dry eye subtype is the short breakup time-type (BUT) of dry eye. The only abnormal finding in this disease is the short BUT, suggesting a relationship with ocular neuropathic pain and eye strain. Recently, data from many studies have accumulated which show that dry eye is a life-style disease. In addition to the treatment of dry eyes, it is becoming possible to prevent the onset by intervening with the daily habits, diet, exercise and sleep, etc. It has been pointed out that oxidative stress is also involved in the pathology of dry eye, and intervention is being carried out by improving diet and taking supplements. Future research will be needed to link clinical findings to the molecular biological findings in the tear film.

Authors+Show Affiliations

Department of Ophthalmology, Keio University School of Medicine, Japan.Department of Ophthalmology, Keio University School of Medicine, Japan.Department of Ophthalmology, Keio University School of Medicine, Japan.Department of Ophthalmology, Keio University School of Medicine, Japan.Department of Ophthalmology, Keio University School of Medicine, Japan; Tsubota Laboratory, Inc., Tokyo, Japan. Electronic address: tsubota@z3.keio.jp.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32004729

Citation

Kojima, Takashi, et al. "Advances in the Diagnosis and Treatment of Dry Eye." Progress in Retinal and Eye Research, 2020, p. 100842.
Kojima T, Dogru M, Kawashima M, et al. Advances in the diagnosis and treatment of dry eye. Prog Retin Eye Res. 2020.
Kojima, T., Dogru, M., Kawashima, M., Nakamura, S., & Tsubota, K. (2020). Advances in the diagnosis and treatment of dry eye. Progress in Retinal and Eye Research, 100842. https://doi.org/10.1016/j.preteyeres.2020.100842
Kojima T, et al. Advances in the Diagnosis and Treatment of Dry Eye. Prog Retin Eye Res. 2020 Jan 29;100842. PubMed PMID: 32004729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advances in the diagnosis and treatment of dry eye. AU - Kojima,Takashi, AU - Dogru,Murat, AU - Kawashima,Motoko, AU - Nakamura,Shigeru, AU - Tsubota,Kazuo, Y1 - 2020/01/29/ PY - 2019/11/03/received PY - 2020/01/19/revised PY - 2020/01/24/accepted PY - 2020/2/1/pubmed PY - 2020/2/1/medline PY - 2020/2/1/entrez KW - Dry eye disease KW - Life style KW - Oxidative stress KW - Tear film-oriented diagnosis KW - Tear film-oriented treatment KW - Visual function SP - 100842 EP - 100842 JF - Progress in retinal and eye research JO - Prog Retin Eye Res N2 - The core mechanism of dry eye is the tear film instability. Tear film-oriented diagnosis (TFOD) is a concept to clarify the cause of tear film instability by tear film, and tear film-oriented treatment (TFOT) is a concept to treat dry eye disease by replacing the lacking components of the tear film layer based on the TFOD. In TFOD, the fluorescein breakup pattern of the tear film is important, and the subtype of dry eye can be judged to some extent from the breakup patterns. Current noninvasive devices related to the dynamic analysis of the tear film and visual acuity enabled the diagnosis of dry eye, subtype analysis, and the extent of severity. In Asian countries, secretagogues represent the main treatment in TFOT. Since meibomian gland dysfunction is a factor that greatly affects the tear breakup time, its treatment is also essential in the dry eye treatment strategy. A newly discovered dry eye subtype is the short breakup time-type (BUT) of dry eye. The only abnormal finding in this disease is the short BUT, suggesting a relationship with ocular neuropathic pain and eye strain. Recently, data from many studies have accumulated which show that dry eye is a life-style disease. In addition to the treatment of dry eyes, it is becoming possible to prevent the onset by intervening with the daily habits, diet, exercise and sleep, etc. It has been pointed out that oxidative stress is also involved in the pathology of dry eye, and intervention is being carried out by improving diet and taking supplements. Future research will be needed to link clinical findings to the molecular biological findings in the tear film. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/32004729/Advances_in_the_diagnosis_and_treatment_of_dry_eye L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(20)30014-8 DB - PRIME DP - Unbound Medicine ER -
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