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Alfuzosin and Its Effect on Ejaculatory Dysfunction: A Systematic Review.
World J Mens Health. 2020 Jan 02 [Online ahead of print]WJ

Abstract

Studies have demonstrated that alfuzosin not only improves lower urinary tract symptoms (LUTS) but also appears to preserve ejaculatory dysfunction (EjD). The objective of this study was to evaluate the impact of alfuzosin on ejaculatory function using the 'Male Sexual Health Questionnaire (MSHQ)-EjD Short Form' - a validated, abridged-version of the 25-item MSHQ specifically assessing EjD. A systematic search of MEDLINE, PubMed, Scopus, Embase, and grey literature was performed in January 2017 to identify relevant cohort studies. Search terms were 'alfuzosin', 'benign prostatic hyperplasia', 'ejaculatory dysfunction' and their synonyms without exclusions. Six cohort studies conducted between 2008 to 2015 were selected for analysis. Three of these were conducted in Korea, one in Thailand, one in China, and one in Tunisia. Overall, 1,371 patients were enrolled in these studies with a median age of 62.3 years. All studies quantified patient LUTS and ejaculatory function using the International Prostate Symptom Score (IPSS) and MSHQ-EjD Short Form, respectively. IPSS had a median decrease of 6.6 while MSHQ-EjD had a median increase of 1.9. This review highlights the very real association between sexual function and LUTS. This systematic review confirms that alfuzosin may improve ejaculatory function in addition to LUTS and should be considered in men who are sexually active or who already complain of deteriorating ejaculation.

Authors+Show Affiliations

Department of Urology, Sydney Adventist Hospital Clinical School, University of Sydney, Wahroonga, NSW, Australia.Department of Urology, Sydney Adventist Hospital Clinical School, University of Sydney, Wahroonga, NSW, Australia.Department of Urology, Sydney Adventist Hospital Clinical School, University of Sydney, Wahroonga, NSW, Australia.Department of Urology, Sydney Adventist Hospital Clinical School, University of Sydney, Wahroonga, NSW, Australia. hwoo@urologist.net.au.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32009306

Citation

Yeung, Haywood E L., et al. "Alfuzosin and Its Effect On Ejaculatory Dysfunction: a Systematic Review." The World Journal of Men's Health, 2020.
Yeung HEL, Sena SJ, Calopedos RJ, et al. Alfuzosin and Its Effect on Ejaculatory Dysfunction: A Systematic Review. World J Mens Health. 2020.
Yeung, H. E. L., Sena, S. J., Calopedos, R. J., & Woo, H. H. (2020). Alfuzosin and Its Effect on Ejaculatory Dysfunction: A Systematic Review. The World Journal of Men's Health. https://doi.org/10.5534/wjmh.180024
Yeung HEL, et al. Alfuzosin and Its Effect On Ejaculatory Dysfunction: a Systematic Review. World J Mens Health. 2020 Jan 2; PubMed PMID: 32009306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alfuzosin and Its Effect on Ejaculatory Dysfunction: A Systematic Review. AU - Yeung,Haywood E L, AU - Sena,Stephen J, AU - Calopedos,Ross J, AU - Woo,Henry H, Y1 - 2020/01/02/ PY - 2018/04/27/received PY - 2018/08/05/revised PY - 2018/08/05/accepted PY - 2020/2/4/entrez KW - Alfuzosin KW - Benign prostatic hyperplasia KW - Ejaculation KW - Lower urinary tract symptoms KW - Sexual dysfunction, Physiological JF - The world journal of men's health JO - World J Mens Health N2 - Studies have demonstrated that alfuzosin not only improves lower urinary tract symptoms (LUTS) but also appears to preserve ejaculatory dysfunction (EjD). The objective of this study was to evaluate the impact of alfuzosin on ejaculatory function using the 'Male Sexual Health Questionnaire (MSHQ)-EjD Short Form' - a validated, abridged-version of the 25-item MSHQ specifically assessing EjD. A systematic search of MEDLINE, PubMed, Scopus, Embase, and grey literature was performed in January 2017 to identify relevant cohort studies. Search terms were 'alfuzosin', 'benign prostatic hyperplasia', 'ejaculatory dysfunction' and their synonyms without exclusions. Six cohort studies conducted between 2008 to 2015 were selected for analysis. Three of these were conducted in Korea, one in Thailand, one in China, and one in Tunisia. Overall, 1,371 patients were enrolled in these studies with a median age of 62.3 years. All studies quantified patient LUTS and ejaculatory function using the International Prostate Symptom Score (IPSS) and MSHQ-EjD Short Form, respectively. IPSS had a median decrease of 6.6 while MSHQ-EjD had a median increase of 1.9. This review highlights the very real association between sexual function and LUTS. This systematic review confirms that alfuzosin may improve ejaculatory function in addition to LUTS and should be considered in men who are sexually active or who already complain of deteriorating ejaculation. SN - 2287-4208 UR - https://www.unboundmedicine.com/medline/citation/32009306/Alfuzosin_and_Its_Effect_on_Ejaculatory_Dysfunction:_A_Systematic_Review L2 - https://wjmh.org/DOIx.php?id=10.5534/wjmh.180024 DB - PRIME DP - Unbound Medicine ER -
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