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Gestational vitamin D and offspring risk of multiple sclerosis: a systematic review and meta-analysis.
Ann Epidemiol. 2020 03; 43:11-17.AE

Abstract

PURPOSE

Our objective was to systematically review and meta-analyze studies that assessed the association between gestational vitamin D levels and risk of multiple sclerosis (MS) in offspring.

METHODS

Embase and Pubmed databases were searched from inception to May 2018. Original, observational studies that investigated both clinically defined MS (in offspring) and vitamin D levels in utero or shortly after birth were included. Two reviewers independently abstracted data and assessed the quality of studies using the Newcastle-Ottawa Quality Assessment Scale. Summary effect estimates and 95% confidence intervals were calculated with random effects models using inverse variance weighting. Determinants of heterogeneity were evaluated.

RESULTS

Four case-control studies of moderate to low risk of bias were included. Summary effect estimates of the effect of higher levels of gestational vitamin D on risk of offspring MS demonstrated a significant protective effect in random effects (OR: 0.63, 95% CI: 0.47, 0.84) models and in a stratified analysis based on study quality. Factors identified as determinants of heterogeneity were the definitions of vitamin D deficiency, the characteristics of study participants, and the quality of the study.

CONCLUSIONS

Sufficient levels of vitamin D during pregnancy may be protective against offspring's development of multiple sclerosis later in life.

Authors+Show Affiliations

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA. Electronic address: elizabeth-jasper@uiowa.edu.Cincinnati Children's Hospital Medical Center, Division of Biostatistics and Epidemiology, Cincinnati, OH; Cincinnati Children's Hospital Medical Center, Division of Developmental and Behavioral Pediatrics, Cincinnati, OH; University of Cincinnati College of Medicine, Cincinnati, OH.Department of General Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA; Center for Access and Delivery Research and Evaluation, Iowa City VA Health Care System, Iowa City, IA.Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

32014337

Citation

Jasper, Elizabeth A., et al. "Gestational Vitamin D and Offspring Risk of Multiple Sclerosis: a Systematic Review and Meta-analysis." Annals of Epidemiology, vol. 43, 2020, pp. 11-17.
Jasper EA, Nidey NL, Schweizer ML, et al. Gestational vitamin D and offspring risk of multiple sclerosis: a systematic review and meta-analysis. Ann Epidemiol. 2020;43:11-17.
Jasper, E. A., Nidey, N. L., Schweizer, M. L., & Ryckman, K. K. (2020). Gestational vitamin D and offspring risk of multiple sclerosis: a systematic review and meta-analysis. Annals of Epidemiology, 43, 11-17. https://doi.org/10.1016/j.annepidem.2019.12.010
Jasper EA, et al. Gestational Vitamin D and Offspring Risk of Multiple Sclerosis: a Systematic Review and Meta-analysis. Ann Epidemiol. 2020;43:11-17. PubMed PMID: 32014337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gestational vitamin D and offspring risk of multiple sclerosis: a systematic review and meta-analysis. AU - Jasper,Elizabeth A, AU - Nidey,Nichole L, AU - Schweizer,Marin L, AU - Ryckman,Kelli K, Y1 - 2020/01/03/ PY - 2019/07/24/received PY - 2019/12/30/accepted PY - 2020/2/6/pubmed PY - 2020/7/28/medline PY - 2020/2/5/entrez KW - Gestation KW - Meta-analysis KW - Multiple sclerosis KW - Pregnancy KW - Vitamin D SP - 11 EP - 17 JF - Annals of epidemiology JO - Ann Epidemiol VL - 43 N2 - PURPOSE: Our objective was to systematically review and meta-analyze studies that assessed the association between gestational vitamin D levels and risk of multiple sclerosis (MS) in offspring. METHODS: Embase and Pubmed databases were searched from inception to May 2018. Original, observational studies that investigated both clinically defined MS (in offspring) and vitamin D levels in utero or shortly after birth were included. Two reviewers independently abstracted data and assessed the quality of studies using the Newcastle-Ottawa Quality Assessment Scale. Summary effect estimates and 95% confidence intervals were calculated with random effects models using inverse variance weighting. Determinants of heterogeneity were evaluated. RESULTS: Four case-control studies of moderate to low risk of bias were included. Summary effect estimates of the effect of higher levels of gestational vitamin D on risk of offspring MS demonstrated a significant protective effect in random effects (OR: 0.63, 95% CI: 0.47, 0.84) models and in a stratified analysis based on study quality. Factors identified as determinants of heterogeneity were the definitions of vitamin D deficiency, the characteristics of study participants, and the quality of the study. CONCLUSIONS: Sufficient levels of vitamin D during pregnancy may be protective against offspring's development of multiple sclerosis later in life. SN - 1873-2585 UR - https://www.unboundmedicine.com/medline/citation/32014337/Gestational_vitamin_D_and_offspring_risk_of_multiple_sclerosis:_a_systematic_review_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(19)30434-X DB - PRIME DP - Unbound Medicine ER -