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Neonatal comorbidities and gasotransmitters.
Nitric Oxide. 2020 04 01; 97:27-32.NO

Abstract

Hydrogen sulfide, nitric oxide, and carbon monoxide are endogenously produced gases that regulate various signaling pathways. The role of these transmitters is complex as constitutive production of these molecules may have anti-inflammatory, anti-microbial, and/or vasodilatory effects whereas induced production or formation of secondary metabolites may lead to cellular death. Given this fine line between friend and foe, therapeutic attenuation of these molecules' production has involved both inhibition of endogenous formation and therapeutic supplementation. All three gases have been implicated as regulators of critical aspects of neonatal physiology, and in turn, comorbidities including necrotizing enterocolitis, hypoxic ischemic encephalopathy, and pulmonary hypertension. In this review, we present current perspectives on these associations, highlight areas where insights remain sparse, and identify areas for potential for future investigations.

Authors+Show Affiliations

Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: sjgentle@uabmc.edu.Section of Neonatal-Perinatal Medicine, University of Oklahoma College of Medicine, Oklahoma City, OK, USA.Department of Pathology and Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32014495

Citation

Gentle, Samuel J., et al. "Neonatal Comorbidities and Gasotransmitters." Nitric Oxide : Biology and Chemistry, vol. 97, 2020, pp. 27-32.
Gentle SJ, Tipple TE, Patel R. Neonatal comorbidities and gasotransmitters. Nitric Oxide. 2020;97:27-32.
Gentle, S. J., Tipple, T. E., & Patel, R. (2020). Neonatal comorbidities and gasotransmitters. Nitric Oxide : Biology and Chemistry, 97, 27-32. https://doi.org/10.1016/j.niox.2020.01.012
Gentle SJ, Tipple TE, Patel R. Neonatal Comorbidities and Gasotransmitters. Nitric Oxide. 2020 04 1;97:27-32. PubMed PMID: 32014495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neonatal comorbidities and gasotransmitters. AU - Gentle,Samuel J, AU - Tipple,Trent E, AU - Patel,Rakesh, Y1 - 2020/01/31/ PY - 2019/07/30/received PY - 2019/12/10/revised PY - 2020/01/29/accepted PY - 2020/2/6/pubmed PY - 2020/11/25/medline PY - 2020/2/5/entrez SP - 27 EP - 32 JF - Nitric oxide : biology and chemistry JO - Nitric Oxide VL - 97 N2 - Hydrogen sulfide, nitric oxide, and carbon monoxide are endogenously produced gases that regulate various signaling pathways. The role of these transmitters is complex as constitutive production of these molecules may have anti-inflammatory, anti-microbial, and/or vasodilatory effects whereas induced production or formation of secondary metabolites may lead to cellular death. Given this fine line between friend and foe, therapeutic attenuation of these molecules' production has involved both inhibition of endogenous formation and therapeutic supplementation. All three gases have been implicated as regulators of critical aspects of neonatal physiology, and in turn, comorbidities including necrotizing enterocolitis, hypoxic ischemic encephalopathy, and pulmonary hypertension. In this review, we present current perspectives on these associations, highlight areas where insights remain sparse, and identify areas for potential for future investigations. SN - 1089-8611 UR - https://www.unboundmedicine.com/medline/citation/32014495/Neonatal_comorbidities_and_gasotransmitters_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1089-8603(19)30229-0 DB - PRIME DP - Unbound Medicine ER -