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Evaluation of a Ultraviolet B Light Emitting Diode (LED) for Producing Vitamin D3 in Human Skin.
Anticancer Res. 2020 Feb; 40(2):719-722.AR

Abstract

AIM

A commercially available light emitting diode (LED) that transmitted narrow band ultraviolet B (UVB) radiation was evaluated for its efficacy and efficiency to produce vitamin D3 in human skin.

MATERIALS AND METHODS

Human skin samples were obtained from surgical procedures. The LED had peak emission wavelength of 295 nm. Skin samples were exposed to the UVB-LED for varying times and then were analyzed by high-pressure liquid chromatography (HPLC) to determine the vitamin D3 content.

RESULTS

There was a statistically significant time- and dose-dependent increase in the percent of 7-dehydrocholesterol that was converted to vitamin D3 in the skin type II samples; 1.3%±0.5, 2.3%±0.6 and 4.5%±1.67 after exposure to 0.75 (11.7 mJ/cm2), 1.5 (23.4 mJ/cm2) and 3 (46.8 mJ/cm2) minimal erythemal doses (MEDs), respectively.

CONCLUSION

The UVB-LED was effective and efficient in generating vitamin D3 in human skin, in vitro. The amount of vitamin D3 production increased in a dose-dependent fashion with increased UVB energy. UVB-LEDs can be developed for devices that can efficiently produce vitamin D3 in human skin.

Authors+Show Affiliations

Section of Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Vitamin D, Skin, and Bone Research Laboratory, Boston University School of Medicine, Boston, MA, U.S.A.Section of Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Vitamin D, Skin, and Bone Research Laboratory, Boston University School of Medicine, Boston, MA, U.S.A.Section of Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Vitamin D, Skin, and Bone Research Laboratory, Boston University School of Medicine, Boston, MA, U.S.A.Section of Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Vitamin D, Skin, and Bone Research Laboratory, Boston University School of Medicine, Boston, MA, U.S.A.Section of Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Vitamin D, Skin, and Bone Research Laboratory, Boston University School of Medicine, Boston, MA, U.S.A.Section of Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Vitamin D, Skin, and Bone Research Laboratory, Boston University School of Medicine, Boston, MA, U.S.A.Section of Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Vitamin D, Skin, and Bone Research Laboratory, Boston University School of Medicine, Boston, MA, U.S.A. mfholick@bu.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32014913

Citation

Veronikis, Angeline J., et al. "Evaluation of a Ultraviolet B Light Emitting Diode (LED) for Producing Vitamin D3 in Human Skin." Anticancer Research, vol. 40, no. 2, 2020, pp. 719-722.
Veronikis AJ, Cevik MB, Allen RH, et al. Evaluation of a Ultraviolet B Light Emitting Diode (LED) for Producing Vitamin D3 in Human Skin. Anticancer Res. 2020;40(2):719-722.
Veronikis, A. J., Cevik, M. B., Allen, R. H., Shirvani, A., Sun, A., Persons, K. S., & Holick, M. F. (2020). Evaluation of a Ultraviolet B Light Emitting Diode (LED) for Producing Vitamin D3 in Human Skin. Anticancer Research, 40(2), 719-722. https://doi.org/10.21873/anticanres.14002
Veronikis AJ, et al. Evaluation of a Ultraviolet B Light Emitting Diode (LED) for Producing Vitamin D3 in Human Skin. Anticancer Res. 2020;40(2):719-722. PubMed PMID: 32014913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of a Ultraviolet B Light Emitting Diode (LED) for Producing Vitamin D3 in Human Skin. AU - Veronikis,Angeline J, AU - Cevik,Muhammet B, AU - Allen,Rachel H, AU - Shirvani,Arash, AU - Sun,Audrey, AU - Persons,Kelly S, AU - Holick,Michael F, PY - 2019/11/21/received PY - 2019/12/30/revised PY - 2020/01/10/accepted PY - 2020/2/5/entrez PY - 2020/2/6/pubmed PY - 2020/2/26/medline KW - Previtamin D3 KW - human skin KW - ultraviolet B radiation KW - ultraviolet radiation light emitting diode (LED) KW - vitamin D3 SP - 719 EP - 722 JF - Anticancer research JO - Anticancer Res VL - 40 IS - 2 N2 - AIM: A commercially available light emitting diode (LED) that transmitted narrow band ultraviolet B (UVB) radiation was evaluated for its efficacy and efficiency to produce vitamin D3 in human skin. MATERIALS AND METHODS: Human skin samples were obtained from surgical procedures. The LED had peak emission wavelength of 295 nm. Skin samples were exposed to the UVB-LED for varying times and then were analyzed by high-pressure liquid chromatography (HPLC) to determine the vitamin D3 content. RESULTS: There was a statistically significant time- and dose-dependent increase in the percent of 7-dehydrocholesterol that was converted to vitamin D3 in the skin type II samples; 1.3%±0.5, 2.3%±0.6 and 4.5%±1.67 after exposure to 0.75 (11.7 mJ/cm2), 1.5 (23.4 mJ/cm2) and 3 (46.8 mJ/cm2) minimal erythemal doses (MEDs), respectively. CONCLUSION: The UVB-LED was effective and efficient in generating vitamin D3 in human skin, in vitro. The amount of vitamin D3 production increased in a dose-dependent fashion with increased UVB energy. UVB-LEDs can be developed for devices that can efficiently produce vitamin D3 in human skin. SN - 1791-7530 UR - https://www.unboundmedicine.com/medline/citation/32014913/Evaluation_of_a_Ultraviolet_B_Light_Emitting_Diode__LED__for_Producing_Vitamin_D3_in_Human_Skin_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=32014913 DB - PRIME DP - Unbound Medicine ER -