Citation
Zhou, Peng, et al. "A Pneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin." Nature, vol. 579, no. 7798, 2020, pp. 270-273.
Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273.
Zhou, P., Yang, X. L., Wang, X. G., Hu, B., Zhang, L., Zhang, W., Si, H. R., Zhu, Y., Li, B., Huang, C. L., Chen, H. D., Chen, J., Luo, Y., Guo, H., Jiang, R. D., Liu, M. Q., Chen, Y., Shen, X. R., Wang, X., ... Shi, Z. L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270-273. https://doi.org/10.1038/s41586-020-2012-7
Zhou P, et al. A Pneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin. Nature. 2020;579(7798):270-273. PubMed PMID: 32015507.
TY - JOUR
T1 - A pneumonia outbreak associated with a new coronavirus of probable bat origin.
AU - Zhou,Peng,
AU - Yang,Xing-Lou,
AU - Wang,Xian-Guang,
AU - Hu,Ben,
AU - Zhang,Lei,
AU - Zhang,Wei,
AU - Si,Hao-Rui,
AU - Zhu,Yan,
AU - Li,Bei,
AU - Huang,Chao-Lin,
AU - Chen,Hui-Dong,
AU - Chen,Jing,
AU - Luo,Yun,
AU - Guo,Hua,
AU - Jiang,Ren-Di,
AU - Liu,Mei-Qin,
AU - Chen,Ying,
AU - Shen,Xu-Rui,
AU - Wang,Xi,
AU - Zheng,Xiao-Shuang,
AU - Zhao,Kai,
AU - Chen,Quan-Jiao,
AU - Deng,Fei,
AU - Liu,Lin-Lin,
AU - Yan,Bing,
AU - Zhan,Fa-Xian,
AU - Wang,Yan-Yi,
AU - Xiao,Geng-Fu,
AU - Shi,Zheng-Li,
Y1 - 2020/02/03/
PY - 2020/01/20/received
PY - 2020/01/29/accepted
PY - 2020/2/6/pubmed
PY - 2020/3/21/medline
PY - 2020/2/5/entrez
SP - 270
EP - 273
JF - Nature
JO - Nature
VL - 579
IS - 7798
N2 - Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1-4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.
SN - 1476-4687
UR - https://www.unboundmedicine.com/medline/citation/32015507/full_citation
DB - PRIME
DP - Unbound Medicine
ER -
