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A pneumonia outbreak associated with a new coronavirus of probable bat origin.
Nature. 2020 03; 579(7798):270-273.Nat

Abstract

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1-4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.

Authors+Show Affiliations

CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.Wuhan Jin Yin-Tan Hospital, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.Wuhan Jin Yin-Tan Hospital, Wuhan, China.Wuhan Jin Yin-Tan Hospital, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. zlshi@wh.iov.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32015507

Citation

Zhou, Peng, et al. "A Pneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin." Nature, vol. 579, no. 7798, 2020, pp. 270-273.
Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273.
Zhou, P., Yang, X. L., Wang, X. G., Hu, B., Zhang, L., Zhang, W., Si, H. R., Zhu, Y., Li, B., Huang, C. L., Chen, H. D., Chen, J., Luo, Y., Guo, H., Jiang, R. D., Liu, M. Q., Chen, Y., Shen, X. R., Wang, X., ... Shi, Z. L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270-273. https://doi.org/10.1038/s41586-020-2012-7
Zhou P, et al. A Pneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin. Nature. 2020;579(7798):270-273. PubMed PMID: 32015507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pneumonia outbreak associated with a new coronavirus of probable bat origin. AU - Zhou,Peng, AU - Yang,Xing-Lou, AU - Wang,Xian-Guang, AU - Hu,Ben, AU - Zhang,Lei, AU - Zhang,Wei, AU - Si,Hao-Rui, AU - Zhu,Yan, AU - Li,Bei, AU - Huang,Chao-Lin, AU - Chen,Hui-Dong, AU - Chen,Jing, AU - Luo,Yun, AU - Guo,Hua, AU - Jiang,Ren-Di, AU - Liu,Mei-Qin, AU - Chen,Ying, AU - Shen,Xu-Rui, AU - Wang,Xi, AU - Zheng,Xiao-Shuang, AU - Zhao,Kai, AU - Chen,Quan-Jiao, AU - Deng,Fei, AU - Liu,Lin-Lin, AU - Yan,Bing, AU - Zhan,Fa-Xian, AU - Wang,Yan-Yi, AU - Xiao,Geng-Fu, AU - Shi,Zheng-Li, Y1 - 2020/02/03/ PY - 2020/01/20/received PY - 2020/01/29/accepted PY - 2020/2/6/pubmed PY - 2020/3/21/medline PY - 2020/2/5/entrez SP - 270 EP - 273 JF - Nature JO - Nature VL - 579 IS - 7798 N2 - Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1-4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV. SN - 1476-4687 UR - https://www.unboundmedicine.com/medline/citation/32015507/full_citation L2 - https://doi.org/10.1038/s41586-020-2012-7 DB - PRIME DP - Unbound Medicine ER -