Publisher Full Text
A pneumonia outbreak associated with a new coronavirus of probable bat origin.Nature. 2020 03; 579(7798):270-273.Nat
Abstract
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1-4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.
Links
MeSH
Angiotensin-Converting Enzyme 2AnimalsAntibodies, ViralBetacoronavirusCOVID-19Cell LineChinaChiropteraChlorocebus aethiopsCoronavirus InfectionsDisease OutbreaksFemaleGenome, ViralHumansMalePeptidyl-Dipeptidase APhylogenyPneumonia, ViralSARS VirusSARS-CoV-2Sequence Homology, Nucleic AcidSevere Acute Respiratory SyndromeVero Cells
Pub Type(s)
Journal Article
Language
eng
PubMed ID
32015507
Clinical Trial Links
Describing Chinese Herbal Medicine Telehealth Care for Symptoms Related to Infectious Diseases Such as COVID-19
Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult.
Citation
Zhou, Peng, et al. "A Pneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin." Nature, vol. 579, no. 7798, 2020, pp. 270-273.
Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273.
Zhou, P., Yang, X. L., Wang, X. G., Hu, B., Zhang, L., Zhang, W., Si, H. R., Zhu, Y., Li, B., Huang, C. L., Chen, H. D., Chen, J., Luo, Y., Guo, H., Jiang, R. D., Liu, M. Q., Chen, Y., Shen, X. R., Wang, X., ... Shi, Z. L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270-273. https://doi.org/10.1038/s41586-020-2012-7
Zhou P, et al. A Pneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin. Nature. 2020;579(7798):270-273. PubMed PMID: 32015507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - A pneumonia outbreak associated with a new coronavirus of probable bat origin.
AU - Zhou,Peng,
AU - Yang,Xing-Lou,
AU - Wang,Xian-Guang,
AU - Hu,Ben,
AU - Zhang,Lei,
AU - Zhang,Wei,
AU - Si,Hao-Rui,
AU - Zhu,Yan,
AU - Li,Bei,
AU - Huang,Chao-Lin,
AU - Chen,Hui-Dong,
AU - Chen,Jing,
AU - Luo,Yun,
AU - Guo,Hua,
AU - Jiang,Ren-Di,
AU - Liu,Mei-Qin,
AU - Chen,Ying,
AU - Shen,Xu-Rui,
AU - Wang,Xi,
AU - Zheng,Xiao-Shuang,
AU - Zhao,Kai,
AU - Chen,Quan-Jiao,
AU - Deng,Fei,
AU - Liu,Lin-Lin,
AU - Yan,Bing,
AU - Zhan,Fa-Xian,
AU - Wang,Yan-Yi,
AU - Xiao,Geng-Fu,
AU - Shi,Zheng-Li,
Y1 - 2020/02/03/
PY - 2020/01/20/received
PY - 2020/01/29/accepted
PY - 2020/2/6/pubmed
PY - 2020/3/21/medline
PY - 2020/2/5/entrez
SP - 270
EP - 273
JF - Nature
JO - Nature
VL - 579
IS - 7798
N2 - Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1-4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.
SN - 1476-4687
UR - https://www.unboundmedicine.com/medline/citation/32015507/full_citation
L2 - https://doi.org/10.1038/s41586-020-2012-7
DB - PRIME
DP - Unbound Medicine
ER -
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