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A pneumonia outbreak associated with a new coronavirus of probable bat origin.
Nature. 2020 03; 579(7798):270-273.Nat

Abstract

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1-4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.

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Publisher Full Text
ncbi.nlm.nih.gov
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Authors+Show Affiliations

Zhou P
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Yang XL
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Wang XG
Wuhan Jin Yin-Tan Hospital, Wuhan, China.
Hu B
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Zhang L
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Zhang W
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Si HR
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.
Zhu Y
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Li B
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Huang CL
Wuhan Jin Yin-Tan Hospital, Wuhan, China.
Chen HD
Wuhan Jin Yin-Tan Hospital, Wuhan, China.
Chen J
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.
Luo Y
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.
Guo H
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.
Jiang RD
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.
Liu MQ
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.
Chen Y
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.
Shen XR
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.
Wang X
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.
Zheng XS
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.
Zhao K
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. University of Chinese Academy of Sciences, Beijing, China.
Chen QJ
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Deng F
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Liu LL
Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Yan B
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Zhan FX
Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Wang YY
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Xiao GF
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Shi ZL
CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. zlshi@wh.iov.cn.

MeSH

Angiotensin-Converting Enzyme 2AnimalsAntibodies, ViralBetacoronavirusCOVID-19Cell LineChinaChiropteraChlorocebus aethiopsCoronavirus InfectionsDisease OutbreaksFemaleGenome, ViralHumansMalePeptidyl-Dipeptidase APhylogenyPneumonia, ViralSARS VirusSARS-CoV-2Sequence Homology, Nucleic AcidSevere Acute Respiratory SyndromeVero Cells

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32015507

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Citation

Zhou, Peng, et al. "A Pneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin." Nature, vol. 579, no. 7798, 2020, pp. 270-273.
Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273.
Zhou, P., Yang, X. L., Wang, X. G., Hu, B., Zhang, L., Zhang, W., Si, H. R., Zhu, Y., Li, B., Huang, C. L., Chen, H. D., Chen, J., Luo, Y., Guo, H., Jiang, R. D., Liu, M. Q., Chen, Y., Shen, X. R., Wang, X., ... Shi, Z. L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270-273. https://doi.org/10.1038/s41586-020-2012-7
Zhou P, et al. A Pneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin. Nature. 2020;579(7798):270-273. PubMed PMID: 32015507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pneumonia outbreak associated with a new coronavirus of probable bat origin. AU - Zhou,Peng, AU - Yang,Xing-Lou, AU - Wang,Xian-Guang, AU - Hu,Ben, AU - Zhang,Lei, AU - Zhang,Wei, AU - Si,Hao-Rui, AU - Zhu,Yan, AU - Li,Bei, AU - Huang,Chao-Lin, AU - Chen,Hui-Dong, AU - Chen,Jing, AU - Luo,Yun, AU - Guo,Hua, AU - Jiang,Ren-Di, AU - Liu,Mei-Qin, AU - Chen,Ying, AU - Shen,Xu-Rui, AU - Wang,Xi, AU - Zheng,Xiao-Shuang, AU - Zhao,Kai, AU - Chen,Quan-Jiao, AU - Deng,Fei, AU - Liu,Lin-Lin, AU - Yan,Bing, AU - Zhan,Fa-Xian, AU - Wang,Yan-Yi, AU - Xiao,Geng-Fu, AU - Shi,Zheng-Li, Y1 - 2020/02/03/ PY - 2020/01/20/received PY - 2020/01/29/accepted PY - 2020/2/6/pubmed PY - 2020/3/21/medline PY - 2020/2/5/entrez SP - 270 EP - 273 JF - Nature JO - Nature VL - 579 IS - 7798 N2 - Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1-4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV. SN - 1476-4687 UR - https://www.unboundmedicine.com/medline/citation/32015507/full_citation L2 - https://doi.org/10.1038/s41586-020-2012-7 DB - PRIME DP - Unbound Medicine ER -