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Interocular symmetry of the foveal avascular zone area in healthy eyes: a swept-source optical coherence tomography angiography study.
Jpn J Ophthalmol. 2020 Mar; 64(2):171-179.JJ

Abstract

PURPOSE

To determine the presence or absence of interocular differences in the foveal avascular zone (FAZ) area in healthy eyes.

STUDY DESIGN

Cross-sectional study.

METHODS

We examined 236 healthy eyes of 118 consecutive subjects (mean age, 39.1 ± 18.9 years). We used swept-source optical coherence tomography angiography (OCTA) images of the FAZ to measure its area from both the superficial capillary plexus (SCP-FAZ) and the whole retinal capillary plexus (WCP-FAZ). We also investigated the relationship between interocular differences in SCP-FAZ and other factors such as: axial length, spherical equivalent, central retinal thickness, and retinal vascular density.

RESULTS

There was no significant difference in the FAZ area between the right and left eyes in either the SCP-FAZ (P = 0.61) or WCP-FAZ (P = 0.80), and the FAZ areas of both eyes showed significant positive correlations (SCP-FAZ; P < 0.001, R2 = 0.884, WCP-FAZ; P < 0.001, R2 = 0.856). Bland-Altman plots showed that the mean interocular difference in SCP-FAZ area was 0.002 ± 0.037 mm2 (95% confidence interval, -0.072-0.075 mm2), and in the WCP-FAZ area, 0.050 ± 0.044 mm2 (95% confidence interval, -0.036-0.137 mm2). Multivariate regression analysis showed that none of the investigated factors were significantly associated with interocular differences in SCP-FAZ (P = 0.61, R2 = 0.138).

CONCLUSIONS

There was no significant interocular difference in SCP- and WCP-FAZ areas in healthy eyes. The normal range of values for interocular difference in SCP-FAZ area was 0.002 ± 0.037 mm2 and in the WCP-FAZ area, 0.050 ± 0.044 mm2.

Authors+Show Affiliations

Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan. Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan.Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan. moriza-y@okayama-u.ac.jp.Department of Vision Informatics, Osaka University Graduate School of Medicine, Osaka, Japan.Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan.Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan.Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan.Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan.Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan.Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan.Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan.Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan.Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho Kita-ku, Okayama, 700-8558, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32016665

Citation

Liu, Mengxuan, et al. "Interocular Symmetry of the Foveal Avascular Zone Area in Healthy Eyes: a Swept-source Optical Coherence Tomography Angiography Study." Japanese Journal of Ophthalmology, vol. 64, no. 2, 2020, pp. 171-179.
Liu M, Fujiwara A, Morizane Y, et al. Interocular symmetry of the foveal avascular zone area in healthy eyes: a swept-source optical coherence tomography angiography study. Jpn J Ophthalmol. 2020;64(2):171-179.
Liu, M., Fujiwara, A., Morizane, Y., Kawasaki, R., Kimura, S., Morizane-Hosokawa, M., Shiode, Y., Hirano, M., Doi, S., Toshima, S., Takahashi, K., Hosogi, M., Ma, X., & Shiraga, F. (2020). Interocular symmetry of the foveal avascular zone area in healthy eyes: a swept-source optical coherence tomography angiography study. Japanese Journal of Ophthalmology, 64(2), 171-179. https://doi.org/10.1007/s10384-020-00719-2
Liu M, et al. Interocular Symmetry of the Foveal Avascular Zone Area in Healthy Eyes: a Swept-source Optical Coherence Tomography Angiography Study. Jpn J Ophthalmol. 2020;64(2):171-179. PubMed PMID: 32016665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interocular symmetry of the foveal avascular zone area in healthy eyes: a swept-source optical coherence tomography angiography study. AU - Liu,Mengxuan, AU - Fujiwara,Atsushi, AU - Morizane,Yuki, AU - Kawasaki,Ryo, AU - Kimura,Shuhei, AU - Morizane-Hosokawa,Mio, AU - Shiode,Yusuke, AU - Hirano,Masayuki, AU - Doi,Shinichiro, AU - Toshima,Shinji, AU - Takahashi,Kosuke, AU - Hosogi,Mika, AU - Ma,Xiang, AU - Shiraga,Fumio, Y1 - 2020/02/03/ PY - 2019/05/09/received PY - 2019/12/27/accepted PY - 2020/2/6/pubmed PY - 2021/1/29/medline PY - 2020/2/5/entrez KW - Foveal avascular zone area KW - Healthy eyes KW - Interocular symmetry KW - Japanese KW - Optical coherence tomography angiography SP - 171 EP - 179 JF - Japanese journal of ophthalmology JO - Jpn J Ophthalmol VL - 64 IS - 2 N2 - PURPOSE: To determine the presence or absence of interocular differences in the foveal avascular zone (FAZ) area in healthy eyes. STUDY DESIGN: Cross-sectional study. METHODS: We examined 236 healthy eyes of 118 consecutive subjects (mean age, 39.1 ± 18.9 years). We used swept-source optical coherence tomography angiography (OCTA) images of the FAZ to measure its area from both the superficial capillary plexus (SCP-FAZ) and the whole retinal capillary plexus (WCP-FAZ). We also investigated the relationship between interocular differences in SCP-FAZ and other factors such as: axial length, spherical equivalent, central retinal thickness, and retinal vascular density. RESULTS: There was no significant difference in the FAZ area between the right and left eyes in either the SCP-FAZ (P = 0.61) or WCP-FAZ (P = 0.80), and the FAZ areas of both eyes showed significant positive correlations (SCP-FAZ; P < 0.001, R2 = 0.884, WCP-FAZ; P < 0.001, R2 = 0.856). Bland-Altman plots showed that the mean interocular difference in SCP-FAZ area was 0.002 ± 0.037 mm2 (95% confidence interval, -0.072-0.075 mm2), and in the WCP-FAZ area, 0.050 ± 0.044 mm2 (95% confidence interval, -0.036-0.137 mm2). Multivariate regression analysis showed that none of the investigated factors were significantly associated with interocular differences in SCP-FAZ (P = 0.61, R2 = 0.138). CONCLUSIONS: There was no significant interocular difference in SCP- and WCP-FAZ areas in healthy eyes. The normal range of values for interocular difference in SCP-FAZ area was 0.002 ± 0.037 mm2 and in the WCP-FAZ area, 0.050 ± 0.044 mm2. SN - 1613-2246 UR - https://www.unboundmedicine.com/medline/citation/32016665/Interocular_symmetry_of_the_foveal_avascular_zone_area_in_healthy_eyes:_a_swept_source_optical_coherence_tomography_angiography_study_ L2 - https://dx.doi.org/10.1007/s10384-020-00719-2 DB - PRIME DP - Unbound Medicine ER -