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CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV).
Radiology. 2020 04; 295(1):202-207.R

Abstract

In this retrospective case series, chest CT scans of 21 symptomatic patients from China infected with the 2019 novel coronavirus (2019-nCoV) were reviewed, with emphasis on identifying and characterizing the most common findings. Typical CT findings included bilateral pulmonary parenchymal ground-glass and consolidative pulmonary opacities, sometimes with a rounded morphology and a peripheral lung distribution. Notably, lung cavitation, discrete pulmonary nodules, pleural effusions, and lymphadenopathy were absent. Follow-up imaging in a subset of patients during the study time window often demonstrated mild or moderate progression of disease, as manifested by increasing extent and density of lung opacities.

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Authors+Show Affiliations

Chung M
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Bernheim A
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Mei X
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Zhang N
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Huang M
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Zeng X
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Cui J
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Xu W
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Yang Y
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Fayad ZA
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Jacobi A
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Li K
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Li S
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).
Shan H
From the Department of Diagnostic, Molecular, and Interventional Radiology (M.C., A.B., M.H., Z.A.F., A.J.) and BioMedical Engineering and Imaging Institute (X.M., Y.Y., Z.A.F.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China (N.Z., X.Z.); Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China (J.C., W.X.); and Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China, 519000 (K.L., S.L., H.S.).

MeSH

AdultAgedBetacoronavirusCOVID-19COVID-19 TestingClinical Laboratory TechniquesCoronavirus InfectionsDisease ProgressionFemaleHumansLungMaleMiddle AgedPneumonia, ViralRetrospective StudiesSARS-CoV-2Severe Acute Respiratory SyndromeTomography, X-Ray Computed

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32017661

Clinical Trial Links

Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
Risk Factors and Computed Tomography Findings in COVID-19.
Sirtuin1 in COVID19 Patients
Lung CT Scan Analysis of SARS-CoV2 Induced Lung Injury

Citation

Chung, Michael, et al. "CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV)." Radiology, vol. 295, no. 1, 2020, pp. 202-207.
Chung M, Bernheim A, Mei X, et al. CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Radiology. 2020;295(1):202-207.
Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., Cui, J., Xu, W., Yang, Y., Fayad, Z. A., Jacobi, A., Li, K., Li, S., & Shan, H. (2020). CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Radiology, 295(1), 202-207. https://doi.org/10.1148/radiol.2020200230
Chung M, et al. CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Radiology. 2020;295(1):202-207. PubMed PMID: 32017661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). AU - Chung,Michael, AU - Bernheim,Adam, AU - Mei,Xueyan, AU - Zhang,Ning, AU - Huang,Mingqian, AU - Zeng,Xianjun, AU - Cui,Jiufa, AU - Xu,Wenjian, AU - Yang,Yang, AU - Fayad,Zahi A, AU - Jacobi,Adam, AU - Li,Kunwei, AU - Li,Shaolin, AU - Shan,Hong, Y1 - 2020/02/04/ PY - 2020/2/6/pubmed PY - 2020/3/21/medline PY - 2020/2/5/entrez SP - 202 EP - 207 JF - Radiology JO - Radiology VL - 295 IS - 1 N2 - In this retrospective case series, chest CT scans of 21 symptomatic patients from China infected with the 2019 novel coronavirus (2019-nCoV) were reviewed, with emphasis on identifying and characterizing the most common findings. Typical CT findings included bilateral pulmonary parenchymal ground-glass and consolidative pulmonary opacities, sometimes with a rounded morphology and a peripheral lung distribution. Notably, lung cavitation, discrete pulmonary nodules, pleural effusions, and lymphadenopathy were absent. Follow-up imaging in a subset of patients during the study time window often demonstrated mild or moderate progression of disease, as manifested by increasing extent and density of lung opacities. SN - 1527-1315 UR - https://www.unboundmedicine.com/medline/citation/32017661/CT_Imaging_Features_of_2019_Novel_Coronavirus__2019_nCoV__ DB - PRIME DP - Unbound Medicine ER -