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Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron.
Pharmaceutics. 2020 Jan 30; 12(2)P

Abstract

The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau® Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient.

Authors+Show Affiliations

FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK.Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.Losan Pharma GmbH, Otto-Hahn-Strasse 13, 79395 Neuenburg, Germany.Losan Pharma GmbH, Otto-Hahn-Strasse 13, 79395 Neuenburg, Germany.Losan Pharma GmbH, Otto-Hahn-Strasse 13, 79395 Neuenburg, Germany.FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK. Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK. Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK. Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma Group (GI-1645), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32019101

Citation

Allahham, Nour, et al. "Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron." Pharmaceutics, vol. 12, no. 2, 2020.
Allahham N, Fina F, Marcuta C, et al. Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron. Pharmaceutics. 2020;12(2).
Allahham, N., Fina, F., Marcuta, C., Kraschew, L., Mohr, W., Gaisford, S., Basit, A. W., & Goyanes, A. (2020). Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron. Pharmaceutics, 12(2). https://doi.org/10.3390/pharmaceutics12020110
Allahham N, et al. Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron. Pharmaceutics. 2020 Jan 30;12(2) PubMed PMID: 32019101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron. AU - Allahham,Nour, AU - Fina,Fabrizio, AU - Marcuta,Carmen, AU - Kraschew,Lilia, AU - Mohr,Wolfgang, AU - Gaisford,Simon, AU - Basit,Abdul W, AU - Goyanes,Alvaro, Y1 - 2020/01/30/ PY - 2019/12/19/received PY - 2020/01/16/revised PY - 2020/01/20/accepted PY - 2020/2/6/entrez PY - 2020/2/6/pubmed PY - 2020/2/6/medline KW - 3D printed drug products KW - additive manufacturing KW - orally disintegrating printlets (ODPs) KW - orally disintegrating tablets (ODTs) KW - personalized medicines KW - printing pharmaceuticals KW - rapid prototyping KW - taste masking KW - three-dimensional printing JF - Pharmaceutics JO - Pharmaceutics VL - 12 IS - 2 N2 - The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau® Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient. SN - 1999-4923 UR - https://www.unboundmedicine.com/medline/citation/32019101/Selective_Laser_Sintering_3D_Printing_of_Orally_Disintegrating_Printlets_Containing_Ondansetron L2 - http://www.mdpi.com/resolver?pii=pharmaceutics12020110 DB - PRIME DP - Unbound Medicine ER -
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