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Compatibility of aztreonam in four commercial peritoneal dialysis fluids.
Sci Rep. 2020 02 04; 10(1):1788.SR

Abstract

The preferable route for treatment of peritoneal dialysis related peritonitis remains the intraperitoneal administration of antibiotics admixed to peritoneal dialysis fluids. It is important to know whether the administered drug is compatible with the PD fluids and its container. In the present study the compatibility of aztreonam with four commercial PDFs at storing temperatures and duration representative for storing conditions in the clinical settings was investigated. Aztreonam concentrations were determined using high-performance liquid chromatography. The antimicrobial activity of aztreonam was evaluated using an E. coli diffusion disk inhibition assay and P. aeruginosa time-kill curves. In Extraneal evaluated at 6 °C, 25 °C and 37 °C aztreonam was stable over the whole study period of 14 days and 24 hours, respectively. In Physioneal and Nutrineal aztreonam was stable at 6 °C for up to 14 days. Antimicrobial activity was retained in all PD fluids over the whole study period. Aztreonam remained stable and was compatible with the PD fluids, particularly with Extraneal or Nutrineal, and no compensatory dose adjustment is needed when stored for up to 14 days at refrigeration temperature before use.

Authors+Show Affiliations

Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria. selma.tobudic@meduniwien.ac.at.Department of Pharmacognosy, University of Vienna, Vienna, Austria.Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.Department of Internal Medicine I, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, St. Poelten, Austria.Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria.Department of Internal Medicine I, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, St. Poelten, Austria.Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria. Department of Dermatology and Tropical Medicine, Military Medical Cluster East, Austrian Armed Forces, Vienna, Austria.Department of Pharmacognosy, University of Vienna, Vienna, Austria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32019947

Citation

Tobudic, Selma, et al. "Compatibility of Aztreonam in Four Commercial Peritoneal Dialysis Fluids." Scientific Reports, vol. 10, no. 1, 2020, p. 1788.
Tobudic S, Prager I, Kussmann M, et al. Compatibility of aztreonam in four commercial peritoneal dialysis fluids. Sci Rep. 2020;10(1):1788.
Tobudic, S., Prager, I., Kussmann, M., Obermüller, M., Ursli, M., Zeitlinger, M., Wiesholzer, M., Burgmann, H., Poeppl, W., & Reznicek, G. (2020). Compatibility of aztreonam in four commercial peritoneal dialysis fluids. Scientific Reports, 10(1), 1788. https://doi.org/10.1038/s41598-020-58391-y
Tobudic S, et al. Compatibility of Aztreonam in Four Commercial Peritoneal Dialysis Fluids. Sci Rep. 2020 02 4;10(1):1788. PubMed PMID: 32019947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compatibility of aztreonam in four commercial peritoneal dialysis fluids. AU - Tobudic,Selma, AU - Prager,Isabella, AU - Kussmann,Manuel, AU - Obermüller,Markus, AU - Ursli,Martin, AU - Zeitlinger,Markus, AU - Wiesholzer,Martin, AU - Burgmann,Heinz, AU - Poeppl,Wolfgang, AU - Reznicek,Gottfried, Y1 - 2020/02/04/ PY - 2019/07/15/received PY - 2020/01/09/accepted PY - 2020/2/6/entrez PY - 2020/2/6/pubmed PY - 2020/2/6/medline SP - 1788 EP - 1788 JF - Scientific reports JO - Sci Rep VL - 10 IS - 1 N2 - The preferable route for treatment of peritoneal dialysis related peritonitis remains the intraperitoneal administration of antibiotics admixed to peritoneal dialysis fluids. It is important to know whether the administered drug is compatible with the PD fluids and its container. In the present study the compatibility of aztreonam with four commercial PDFs at storing temperatures and duration representative for storing conditions in the clinical settings was investigated. Aztreonam concentrations were determined using high-performance liquid chromatography. The antimicrobial activity of aztreonam was evaluated using an E. coli diffusion disk inhibition assay and P. aeruginosa time-kill curves. In Extraneal evaluated at 6 °C, 25 °C and 37 °C aztreonam was stable over the whole study period of 14 days and 24 hours, respectively. In Physioneal and Nutrineal aztreonam was stable at 6 °C for up to 14 days. Antimicrobial activity was retained in all PD fluids over the whole study period. Aztreonam remained stable and was compatible with the PD fluids, particularly with Extraneal or Nutrineal, and no compensatory dose adjustment is needed when stored for up to 14 days at refrigeration temperature before use. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/32019947/Compatibility_of_aztreonam_in_four_commercial_peritoneal_dialysis_fluids_ L2 - https://doi.org/10.1038/s41598-020-58391-y DB - PRIME DP - Unbound Medicine ER -