Tags

Type your tag names separated by a space and hit enter

HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer.
Infect Agent Cancer. 2020; 15:6.IA

Abstract

Cervical cancer is the fourth most common malignant tumor in women worldwide. The persistent infection of high-risk Human Papillomavirus (hrHPV) is considered to be the primary cause of this disease. As an innate immune receptor, the nucleotide-binding oligomerization domain protein-1 (NOD1) recognizes the pathogen-associated molecular pattern (PAMP), subsequently initiating immune responses. NOD1 is also involved in the apoptotic signaling pathway and mutates in many cancer cells. In the study, we revealed that NOD1 expression decreased during the progression of cervical intraepithelial neoplasia to cervical cancer and that HPV16 E6/E7 oncoproteins induced down-regulation of NOD1. Moreover, the activation of NOD1 promoted the apoptosis of HPV16-positive cervical cancer cells. The data indicated that the dysregulation of NOD1-mediated inflammation and apoptosis may contribute to cervical intraepithelial neoplasia progression and cervical cancer.

Authors+Show Affiliations

Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 People's Republic of China.Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 People's Republic of China.Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 People's Republic of China.Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 People's Republic of China.Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 People's Republic of China.Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 People's Republic of China.Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 People's Republic of China.Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 People's Republic of China.Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080 People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32021648

Citation

Liu, Xubin, et al. "HPV-mediated Down-regulation of NOD1 Inhibits Apoptosis in Cervical Cancer." Infectious Agents and Cancer, vol. 15, 2020, p. 6.
Liu X, Ma H, Fei L, et al. HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer. Infect Agents Cancer. 2020;15:6.
Liu, X., Ma, H., Fei, L., Jiang, M., Xia, M., Bai, L., Pi, X., Chen, S., & Yu, L. (2020). HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer. Infectious Agents and Cancer, 15, 6. https://doi.org/10.1186/s13027-020-0272-3
Liu X, et al. HPV-mediated Down-regulation of NOD1 Inhibits Apoptosis in Cervical Cancer. Infect Agents Cancer. 2020;15:6. PubMed PMID: 32021648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer. AU - Liu,Xubin, AU - Ma,Hanyu, AU - Fei,Lingyan, AU - Jiang,Mengjie, AU - Xia,Meng, AU - Bai,Lihong, AU - Pi,Xufang, AU - Chen,Shangwu, AU - Yu,Li, Y1 - 2020/01/30/ PY - 2019/05/19/received PY - 2020/01/12/accepted PY - 2020/2/6/entrez PY - 2020/2/6/pubmed PY - 2020/2/6/medline KW - Apoptosis KW - Cervical cancer KW - Cervical intraepithelial neoplasia KW - HPV16 E6/E7 KW - NOD1 SP - 6 EP - 6 JF - Infectious agents and cancer JO - Infect. Agents Cancer VL - 15 N2 - Cervical cancer is the fourth most common malignant tumor in women worldwide. The persistent infection of high-risk Human Papillomavirus (hrHPV) is considered to be the primary cause of this disease. As an innate immune receptor, the nucleotide-binding oligomerization domain protein-1 (NOD1) recognizes the pathogen-associated molecular pattern (PAMP), subsequently initiating immune responses. NOD1 is also involved in the apoptotic signaling pathway and mutates in many cancer cells. In the study, we revealed that NOD1 expression decreased during the progression of cervical intraepithelial neoplasia to cervical cancer and that HPV16 E6/E7 oncoproteins induced down-regulation of NOD1. Moreover, the activation of NOD1 promoted the apoptosis of HPV16-positive cervical cancer cells. The data indicated that the dysregulation of NOD1-mediated inflammation and apoptosis may contribute to cervical intraepithelial neoplasia progression and cervical cancer. SN - 1750-9378 UR - https://www.unboundmedicine.com/medline/citation/32021648/HPV-mediated_down-regulation_of_NOD1_inhibits_apoptosis_in_cervical_cancer L2 - https://infectagentscancer.biomedcentral.com/articles/10.1186/s13027-020-0272-3 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.