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Subdivision of modified-release tablets: state-of-the-art and future perspectives.
Ther Deliv. 2020 May; 11(5):285-287.TD

Abstract

Tablet splitting is a practice disseminated among health professionals for dose adjustments, swallowing facilitation or even treatment cost reduction. Nevertheless, tablets not designed for this purpose cause imprecise dosage and stability loss with important therapeutic repercussions. Novel technologies of modified drug release tablets have come to market including new materials and innovative production processes, for example, polymeric matrix, orodispersible, 3D printing, MUPs, etc. The heterogeneity and complexity of these tablets go well beyond a traditional gastroresistant coating tablet, making orientations on the practice of tablet subdivision difficult. This editorial aims to provide a critical and up-to-date evaluation of this scenario based on the most recent studies involving the subdivision of modified-release tablets.

Authors+Show Affiliations

Laboratory of Food, Drugs, & Cosmetics (LTMAC), University of Brasília (UnB), 70910-900, Brasília, DF, Brazil.Laboratory of Food, Drugs, & Cosmetics (LTMAC), University of Brasília (UnB), 70910-900, Brasília, DF, Brazil.Laboratory of Food, Drugs, & Cosmetics (LTMAC), University of Brasília (UnB), 70910-900, Brasília, DF, Brazil.

Pub Type(s)

Editorial

Language

eng

PubMed ID

32024453

Citation

Cunha-Filho, Marcilio, et al. "Subdivision of Modified-release Tablets: State-of-the-art and Future Perspectives." Therapeutic Delivery, vol. 11, no. 5, 2020, pp. 285-287.
Cunha-Filho M, Gelfuso GM, Gratieri T. Subdivision of modified-release tablets: state-of-the-art and future perspectives. Ther Deliv. 2020;11(5):285-287.
Cunha-Filho, M., Gelfuso, G. M., & Gratieri, T. (2020). Subdivision of modified-release tablets: state-of-the-art and future perspectives. Therapeutic Delivery, 11(5), 285-287. https://doi.org/10.4155/tde-2020-0006
Cunha-Filho M, Gelfuso GM, Gratieri T. Subdivision of Modified-release Tablets: State-of-the-art and Future Perspectives. Ther Deliv. 2020;11(5):285-287. PubMed PMID: 32024453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subdivision of modified-release tablets: state-of-the-art and future perspectives. AU - Cunha-Filho,Marcilio, AU - Gelfuso,Guilherme M, AU - Gratieri,Tais, Y1 - 2020/02/06/ PY - 2020/2/7/pubmed PY - 2020/2/7/medline PY - 2020/2/7/entrez KW - dose variation KW - modified-release tablets KW - multilayer tablets KW - multiple-unit particulate system KW - orally disintegrating tablets KW - stability KW - sustained-release tablets KW - tablets subdivision KW - therapy personalization SP - 285 EP - 287 JF - Therapeutic delivery JO - Ther Deliv VL - 11 IS - 5 N2 - Tablet splitting is a practice disseminated among health professionals for dose adjustments, swallowing facilitation or even treatment cost reduction. Nevertheless, tablets not designed for this purpose cause imprecise dosage and stability loss with important therapeutic repercussions. Novel technologies of modified drug release tablets have come to market including new materials and innovative production processes, for example, polymeric matrix, orodispersible, 3D printing, MUPs, etc. The heterogeneity and complexity of these tablets go well beyond a traditional gastroresistant coating tablet, making orientations on the practice of tablet subdivision difficult. This editorial aims to provide a critical and up-to-date evaluation of this scenario based on the most recent studies involving the subdivision of modified-release tablets. SN - 2041-6008 UR - https://www.unboundmedicine.com/medline/citation/32024453/Subdivision_of_modified-release_tablets:_state-of-the-art_and_future_perspectives L2 - https://www.future-science.com/doi/10.4155/tde-2020-0006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=www.ncbi.nlm.nih.gov DB - PRIME DP - Unbound Medicine ER -
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