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Association of orthostatic hypotension with Parkinson's disease: a meta-analysis.
Neurol Sci. 2020 Jun; 41(6):1419-1426.NS

Abstract

OBJECTIVE

Orthostatic hypotension (OH) is a common non-motor sign of Parkinson's disease (PD). Several epidemiological studies have estimated the association between OH and PD with controversial results. Here, a meta-analysis was conducted to evaluate the association between them.

METHODS

PubMed, Embase, Web of Science, CNKI (Chinese National Knowledge Infrastructure), VIP (Database of Chinese Scientific and Technical Periodicals), and Wanfang databases were searched for eligible publications from October 2003 to December 2017. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. Random effect model was used to calculate the pooled odds ratio (OR) with 95% confidence intervals (CIs) from individual studies. Publication bias was estimated by Egger's test, Begg's test, and the funnel plot.

RESULTS

Nineteen studies involving 1620 PD patients and 898 healthy controls were included in this meta-analysis. The pooled estimate of the prevalence of OH in PD was 27.7% compared with 7.9% of that in control. The pooled OR of OH with PD was 4.343 (95% CI 3.323-5.676) with a low heterogeneity (I2 = 12.5%, Pheterogeneity = 0.301).

CONCLUSION

In the present meta-analysis, the pooled OR of OH with PD was 4.343 (95% CI 3.323-5.676) with a low heterogeneity, which showed a significant association between OH and increased risk of PD.

Authors+Show Affiliations

Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China.Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China.Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China.Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China. hongjiang@qdu.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

32030568

Citation

Mu, Feifei, et al. "Association of Orthostatic Hypotension With Parkinson's Disease: a Meta-analysis." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 41, no. 6, 2020, pp. 1419-1426.
Mu F, Jiao Q, Du X, et al. Association of orthostatic hypotension with Parkinson's disease: a meta-analysis. Neurol Sci. 2020;41(6):1419-1426.
Mu, F., Jiao, Q., Du, X., & Jiang, H. (2020). Association of orthostatic hypotension with Parkinson's disease: a meta-analysis. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 41(6), 1419-1426. https://doi.org/10.1007/s10072-020-04277-w
Mu F, et al. Association of Orthostatic Hypotension With Parkinson's Disease: a Meta-analysis. Neurol Sci. 2020;41(6):1419-1426. PubMed PMID: 32030568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of orthostatic hypotension with Parkinson's disease: a meta-analysis. AU - Mu,Feifei, AU - Jiao,Qian, AU - Du,Xixun, AU - Jiang,Hong, Y1 - 2020/02/06/ PY - 2019/12/06/received PY - 2020/02/02/accepted PY - 2020/2/8/pubmed PY - 2021/2/27/medline PY - 2020/2/8/entrez KW - Meta-analysis KW - Odds ratio KW - Orthostatic hypotension KW - Parkinson’s disease SP - 1419 EP - 1426 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 41 IS - 6 N2 - OBJECTIVE: Orthostatic hypotension (OH) is a common non-motor sign of Parkinson's disease (PD). Several epidemiological studies have estimated the association between OH and PD with controversial results. Here, a meta-analysis was conducted to evaluate the association between them. METHODS: PubMed, Embase, Web of Science, CNKI (Chinese National Knowledge Infrastructure), VIP (Database of Chinese Scientific and Technical Periodicals), and Wanfang databases were searched for eligible publications from October 2003 to December 2017. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. Random effect model was used to calculate the pooled odds ratio (OR) with 95% confidence intervals (CIs) from individual studies. Publication bias was estimated by Egger's test, Begg's test, and the funnel plot. RESULTS: Nineteen studies involving 1620 PD patients and 898 healthy controls were included in this meta-analysis. The pooled estimate of the prevalence of OH in PD was 27.7% compared with 7.9% of that in control. The pooled OR of OH with PD was 4.343 (95% CI 3.323-5.676) with a low heterogeneity (I2 = 12.5%, Pheterogeneity = 0.301). CONCLUSION: In the present meta-analysis, the pooled OR of OH with PD was 4.343 (95% CI 3.323-5.676) with a low heterogeneity, which showed a significant association between OH and increased risk of PD. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/32030568/Association_of_orthostatic_hypotension_with_Parkinson's_disease:_a_meta_analysis_ L2 - https://link.springer.com/10.1007/s10072-020-04277-w DB - PRIME DP - Unbound Medicine ER -
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