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Preparation and evaluation of orally disintegrating tablets containing taste masked microparticles of acetaminophen.
Pharmazie. 2020 01 02; 75(1):2-6.P

Abstract

In the present work, taste masked particles of acetaminophen (AAP), a highly soluble bitter tasting drug, were developed and ODT containing the taste masked particles were prepared. Taste masked particles of AAP were prepared using different amounts of tetraglycerol polyricinoleate (TGPR) and Eudragit ®E100. Although the drug content ratio and drug recovery decreased with increasing TGPR, drug release from AAP-CR100 particles containing a large amount of TGPR was mostly suppressed for 2 min. Hence, AAP-CR100 was incorporated into ODT as taste masked particles for AAP. Three major disintegrants were used for ODT, and it was confirmed that the tensile strength of all formulations showed applicable hardness for handling. The AAP-CR100-CP(40) formulation containing crospovidone showed the shortest disintegration time and the drug release from AAP-CR100-CP(40) into pH 6.8 test solution was suppressed compared with commercial AAP tablets. Because the drug release from AAP-CR100-CP(40) into the pH 1.2 test solution was rapid, it was suggested that drug release from AAP-CR100-CP(40) is suppressed in the oral cavity, and the drug is released promptly in the stomach. Thus AAP-CR100-CP(40) may be useful as an ODT in which the dissolution of AAP in the oral cavity is suppressed.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32033625

Citation

Ikeuchi-Takahashi, Y, et al. "Preparation and Evaluation of Orally Disintegrating Tablets Containing Taste Masked Microparticles of Acetaminophen." Die Pharmazie, vol. 75, no. 1, 2020, pp. 2-6.
Ikeuchi-Takahashi Y, Ito S, Itokawa A, et al. Preparation and evaluation of orally disintegrating tablets containing taste masked microparticles of acetaminophen. Pharmazie. 2020;75(1):2-6.
Ikeuchi-Takahashi, Y., Ito, S., Itokawa, A., Ota, M., Onuki, Y., Hidaka, S., & Onishi, H. (2020). Preparation and evaluation of orally disintegrating tablets containing taste masked microparticles of acetaminophen. Die Pharmazie, 75(1), 2-6. https://doi.org/10.1691/ph.2020.9126
Ikeuchi-Takahashi Y, et al. Preparation and Evaluation of Orally Disintegrating Tablets Containing Taste Masked Microparticles of Acetaminophen. Pharmazie. 2020 01 2;75(1):2-6. PubMed PMID: 32033625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and evaluation of orally disintegrating tablets containing taste masked microparticles of acetaminophen. AU - Ikeuchi-Takahashi,Y, AU - Ito,S, AU - Itokawa,A, AU - Ota,M, AU - Onuki,Y, AU - Hidaka,S, AU - Onishi,H, PY - 2020/2/9/entrez PY - 2020/2/9/pubmed PY - 2020/2/9/medline SP - 2 EP - 6 JF - Die Pharmazie JO - Pharmazie VL - 75 IS - 1 N2 - In the present work, taste masked particles of acetaminophen (AAP), a highly soluble bitter tasting drug, were developed and ODT containing the taste masked particles were prepared. Taste masked particles of AAP were prepared using different amounts of tetraglycerol polyricinoleate (TGPR) and Eudragit ®E100. Although the drug content ratio and drug recovery decreased with increasing TGPR, drug release from AAP-CR100 particles containing a large amount of TGPR was mostly suppressed for 2 min. Hence, AAP-CR100 was incorporated into ODT as taste masked particles for AAP. Three major disintegrants were used for ODT, and it was confirmed that the tensile strength of all formulations showed applicable hardness for handling. The AAP-CR100-CP(40) formulation containing crospovidone showed the shortest disintegration time and the drug release from AAP-CR100-CP(40) into pH 6.8 test solution was suppressed compared with commercial AAP tablets. Because the drug release from AAP-CR100-CP(40) into the pH 1.2 test solution was rapid, it was suggested that drug release from AAP-CR100-CP(40) is suppressed in the oral cavity, and the drug is released promptly in the stomach. Thus AAP-CR100-CP(40) may be useful as an ODT in which the dissolution of AAP in the oral cavity is suppressed. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/32033625/Preparation_and_evaluation_of_orally_disintegrating_tablets_containing_taste_masked_microparticles_of_acetaminophen L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=0031-7144&volume=75&issue=1&spage=2&aulast=Ikeuchi-Takahashi DB - PRIME DP - Unbound Medicine ER -
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