Tags

Type your tag names separated by a space and hit enter

Sural nerve biopsy findings in leprosy: a qualitative and quantitative light and electron microscope study in 4 treated cases of the lepromatous spectrum.
Clin Neuropathol. 1988 May-Jun; 7(3):120-30.CN

Abstract

Reports on biopsy findings in multifascicular nerves in lepromatous leprosy (LL) are rare and detailed morphometrical data are not available. In a case of early LL with normal electrodiagnostic findings in sural nerve, the present study revealed marked segmental de- and remyelination concomitant with the sequelae of considerable Wallerian degeneration of preferentially small myelinated fibers (MF) in spite of a normal number/nerve and density/mm2. Segmental de- and remyelination of several consecutive internodes in teased fibers suggests continuous bacterial spread via Schwann cells. In 2 more advanced LL-cases, nervous parenchyme was severely reduced, in a borderline lepromatous (BL) case obviously in part caused by cell infiltrates and granulomata. Distinct fascicle differences in MF-involvement were demonstrated by coefficients of variation of MF/mm2 and teased fiber preparations in LL, consistent with the hypothesis of initial focal spread of bacteria. Numbers and densities of endoneurial vessels were increased only in the later stages of LL. Enlargement of endoneurial area, due to different factors, was encountered except for the most severe LL-case with extensive endoneurial collagenization. Morphometric results were compared with those of other neuropathies. Intact and degenerating bacteria mostly in phagosomes of Schwann cells associated with unmyelinated axons and in macrophages were seen only in the early LL- and the BL-case. Sparse mononuclear cell infiltrates and small focal necrosis, present even in LL-cases, underline the complex pathogenesis of nerve fiber involvement.

Authors+Show Affiliations

Department of Neurology, University of Cologne, Köln, FRG.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3203481

Citation

Gibbels, E, et al. "Sural Nerve Biopsy Findings in Leprosy: a Qualitative and Quantitative Light and Electron Microscope Study in 4 Treated Cases of the Lepromatous Spectrum." Clinical Neuropathology, vol. 7, no. 3, 1988, pp. 120-30.
Gibbels E, Behse F, Klingmüller G, et al. Sural nerve biopsy findings in leprosy: a qualitative and quantitative light and electron microscope study in 4 treated cases of the lepromatous spectrum. Clin Neuropathol. 1988;7(3):120-30.
Gibbels, E., Behse, F., Klingmüller, G., Henke-Lübke, U., Haupt, W. F., & Gollmer, E. (1988). Sural nerve biopsy findings in leprosy: a qualitative and quantitative light and electron microscope study in 4 treated cases of the lepromatous spectrum. Clinical Neuropathology, 7(3), 120-30.
Gibbels E, et al. Sural Nerve Biopsy Findings in Leprosy: a Qualitative and Quantitative Light and Electron Microscope Study in 4 Treated Cases of the Lepromatous Spectrum. Clin Neuropathol. 1988 May-Jun;7(3):120-30. PubMed PMID: 3203481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sural nerve biopsy findings in leprosy: a qualitative and quantitative light and electron microscope study in 4 treated cases of the lepromatous spectrum. AU - Gibbels,E, AU - Behse,F, AU - Klingmüller,G, AU - Henke-Lübke,U, AU - Haupt,W F, AU - Gollmer,E, PY - 1988/5/1/pubmed PY - 1988/5/1/medline PY - 1988/5/1/entrez SP - 120 EP - 30 JF - Clinical neuropathology JO - Clin Neuropathol VL - 7 IS - 3 N2 - Reports on biopsy findings in multifascicular nerves in lepromatous leprosy (LL) are rare and detailed morphometrical data are not available. In a case of early LL with normal electrodiagnostic findings in sural nerve, the present study revealed marked segmental de- and remyelination concomitant with the sequelae of considerable Wallerian degeneration of preferentially small myelinated fibers (MF) in spite of a normal number/nerve and density/mm2. Segmental de- and remyelination of several consecutive internodes in teased fibers suggests continuous bacterial spread via Schwann cells. In 2 more advanced LL-cases, nervous parenchyme was severely reduced, in a borderline lepromatous (BL) case obviously in part caused by cell infiltrates and granulomata. Distinct fascicle differences in MF-involvement were demonstrated by coefficients of variation of MF/mm2 and teased fiber preparations in LL, consistent with the hypothesis of initial focal spread of bacteria. Numbers and densities of endoneurial vessels were increased only in the later stages of LL. Enlargement of endoneurial area, due to different factors, was encountered except for the most severe LL-case with extensive endoneurial collagenization. Morphometric results were compared with those of other neuropathies. Intact and degenerating bacteria mostly in phagosomes of Schwann cells associated with unmyelinated axons and in macrophages were seen only in the early LL- and the BL-case. Sparse mononuclear cell infiltrates and small focal necrosis, present even in LL-cases, underline the complex pathogenesis of nerve fiber involvement. SN - 0722-5091 UR - https://www.unboundmedicine.com/medline/citation/3203481/Sural_nerve_biopsy_findings_in_leprosy:_a_qualitative_and_quantitative_light_and_electron_microscope_study_in_4_treated_cases_of_the_lepromatous_spectrum_ L2 - http://www.diseaseinfosearch.org/result/8734 DB - PRIME DP - Unbound Medicine ER -