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An easy-to-prepare microshotgun for efficient transmembrane delivery by powering nanoparticles.
J Control Release. 2020 Feb 06; 321:119-131.JC

Abstract

Biological barriers are the first line of defense against pathogen invasions, but they can also present as critical obstacles to drug delivery. Despite a variety of strategies have been developed recently to overcome them, significant efforts are still needed to achieve safer and more effective drug delivery. Herein, we constructed a metal-free, "slim waist" shaped microshotgun delivery device, which was able to cross the tympanic membrane and round window membrane. The efficient penetration was powered by the gas generating reactions of self-contained chemicals. This device is advantageous in several aspects. First, the device could be prepared using simple procedures, common equipment and affordable materials. Second, the device is deemed biocompatible, revealed by low cytotoxicity, normal blood cell parameters and histological morphology after single/repeated administration. Third, the nanoparticles loaded in the microshotgun were able to actively penetrate the epithelial layer of the membrane after the first acceleration, and can penetrate the endothelial layer of tympanic membrane using external magnetic field as the secondary power to align and accelerate the nanoparticles. In addition, the micro-penetration of membrane induced by microshotgun could recover in a short time as observed in high-resolution scanning electron microscopy. This easy-to-get, efficient and safe micro device provides a new delivery platform for the treatment of diseases in the middle ear and inner ear, and holds potential to overcome the physiologic barrier in the body.

Authors+Show Affiliations

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou 510006, China.School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou 510006, China.School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou 510006, China.School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: gywenl@163.com.School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: cg753@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32035909

Citation

Liang, Zhongping, et al. "An Easy-to-prepare Microshotgun for Efficient Transmembrane Delivery By Powering Nanoparticles." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 321, 2020, pp. 119-131.
Liang Z, Yu H, Lai J, et al. An easy-to-prepare microshotgun for efficient transmembrane delivery by powering nanoparticles. J Control Release. 2020;321:119-131.
Liang, Z., Yu, H., Lai, J., Wen, L., & Chen, G. (2020). An easy-to-prepare microshotgun for efficient transmembrane delivery by powering nanoparticles. Journal of Controlled Release : Official Journal of the Controlled Release Society, 321, 119-131. https://doi.org/10.1016/j.jconrel.2020.02.016
Liang Z, et al. An Easy-to-prepare Microshotgun for Efficient Transmembrane Delivery By Powering Nanoparticles. J Control Release. 2020 Feb 6;321:119-131. PubMed PMID: 32035909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An easy-to-prepare microshotgun for efficient transmembrane delivery by powering nanoparticles. AU - Liang,Zhongping, AU - Yu,Hang, AU - Lai,Jianfeng, AU - Wen,Lu, AU - Chen,Gang, Y1 - 2020/02/06/ PY - 2019/10/08/received PY - 2020/01/30/revised PY - 2020/02/06/accepted PY - 2020/2/10/pubmed PY - 2020/2/10/medline PY - 2020/2/10/entrez KW - Biological barrier KW - Microshotgun KW - Round window membrane KW - Transmembrane delivery KW - Tympanic membrane SP - 119 EP - 131 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 321 N2 - Biological barriers are the first line of defense against pathogen invasions, but they can also present as critical obstacles to drug delivery. Despite a variety of strategies have been developed recently to overcome them, significant efforts are still needed to achieve safer and more effective drug delivery. Herein, we constructed a metal-free, "slim waist" shaped microshotgun delivery device, which was able to cross the tympanic membrane and round window membrane. The efficient penetration was powered by the gas generating reactions of self-contained chemicals. This device is advantageous in several aspects. First, the device could be prepared using simple procedures, common equipment and affordable materials. Second, the device is deemed biocompatible, revealed by low cytotoxicity, normal blood cell parameters and histological morphology after single/repeated administration. Third, the nanoparticles loaded in the microshotgun were able to actively penetrate the epithelial layer of the membrane after the first acceleration, and can penetrate the endothelial layer of tympanic membrane using external magnetic field as the secondary power to align and accelerate the nanoparticles. In addition, the micro-penetration of membrane induced by microshotgun could recover in a short time as observed in high-resolution scanning electron microscopy. This easy-to-get, efficient and safe micro device provides a new delivery platform for the treatment of diseases in the middle ear and inner ear, and holds potential to overcome the physiologic barrier in the body. SN - 1873-4995 UR - https://www.unboundmedicine.com/medline/citation/32035909/An_easy-to-prepare_microshotgun_for_efficient_transmembrane_delivery_by_powering_nanoparticles L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-3659(20)30093-6 DB - PRIME DP - Unbound Medicine ER -
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