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A decade of FRAX: how has it changed the management of osteoporosis?
Aging Clin Exp Res. 2020 Feb; 32(2):187-196.AC

Abstract

The fracture risk assessment tool, FRAX®, was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, 71 models have been made available for 66 countries covering more than 80% of the world population. The website receives approximately 3 million visits annually. Following independent validation, FRAX has been incorporated into more than 80 guidelines worldwide. The application of FRAX in assessment guidelines has been heterogeneous with the adoption of several different approaches in setting intervention thresholds. Whereas most guidelines adopt a case-finding strategy, the case for FRAX-based community screening in the elderly is increasing. The relationship between FRAX and efficacy of intervention has been explored and is expected to influence treatment guidelines in the future.

Authors+Show Affiliations

Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK. w.j.pontefract@shef.ac.uk. Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia. w.j.pontefract@shef.ac.uk.MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK. Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.Department of Internal Medicine and Clinical Nutrition, Institute of Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.University of Manitoba, Winnipeg, Canada.Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK. MRC and Arthritis Research UK Centre for Integrated Research in Musculoskeletal Ageing, Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32043227

Citation

Kanis, John A., et al. "A Decade of FRAX: How Has It Changed the Management of Osteoporosis?" Aging Clinical and Experimental Research, vol. 32, no. 2, 2020, pp. 187-196.
Kanis JA, Harvey NC, Johansson H, et al. A decade of FRAX: how has it changed the management of osteoporosis? Aging Clin Exp Res. 2020;32(2):187-196.
Kanis, J. A., Harvey, N. C., Johansson, H., Liu, E., Vandenput, L., Lorentzon, M., Leslie, W. D., & McCloskey, E. V. (2020). A decade of FRAX: how has it changed the management of osteoporosis? Aging Clinical and Experimental Research, 32(2), 187-196. https://doi.org/10.1007/s40520-019-01432-y
Kanis JA, et al. A Decade of FRAX: How Has It Changed the Management of Osteoporosis. Aging Clin Exp Res. 2020;32(2):187-196. PubMed PMID: 32043227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A decade of FRAX: how has it changed the management of osteoporosis? AU - Kanis,John A, AU - Harvey,Nicholas C, AU - Johansson,Helena, AU - Liu,Enwu, AU - Vandenput,Liesbeth, AU - Lorentzon,Mattias, AU - Leslie,William D, AU - McCloskey,Eugene V, Y1 - 2020/02/11/ PY - 2019/10/23/received PY - 2019/11/21/accepted PY - 2020/2/12/pubmed PY - 2020/6/17/medline PY - 2020/2/12/entrez KW - Clinical risk factors KW - FRAX KW - Fracture probability KW - Intervention thresholds KW - Risk assessment KW - Screening SP - 187 EP - 196 JF - Aging clinical and experimental research JO - Aging Clin Exp Res VL - 32 IS - 2 N2 - The fracture risk assessment tool, FRAX®, was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, 71 models have been made available for 66 countries covering more than 80% of the world population. The website receives approximately 3 million visits annually. Following independent validation, FRAX has been incorporated into more than 80 guidelines worldwide. The application of FRAX in assessment guidelines has been heterogeneous with the adoption of several different approaches in setting intervention thresholds. Whereas most guidelines adopt a case-finding strategy, the case for FRAX-based community screening in the elderly is increasing. The relationship between FRAX and efficacy of intervention has been explored and is expected to influence treatment guidelines in the future. SN - 1720-8319 UR - https://www.unboundmedicine.com/medline/citation/32043227/A_decade_of_FRAX:_how_has_it_changed_the_management_of_osteoporosis L2 - https://dx.doi.org/10.1007/s40520-019-01432-y DB - PRIME DP - Unbound Medicine ER -