Tags

Type your tag names separated by a space and hit enter

Superficial Peritoneal Endometriosis: Clinical Characteristics of 203 Confirmed Cases and 1292 Endometriosis-Free Controls.
Reprod Sci. 2020 01; 27(1):309-315.RS

Abstract

The aim of this study was to characterize a large sample of women with superficial peritoneal endometriosis (SUP) and no other types of endometriosis in order to test the association of SUP with gynecologic symptoms. We included 203 cases of histologically proven SUP and 1292 endometriosis-free controls diagnosed between January 2004 and July 2017. The participants were non-pregnant patients aged 18 to 42 years submitted to a laparoscopy or laparotomy for a benign gynecologic condition. We excluded all cases of ovarian endometrioma, deep infiltrating endometriosis, and women who had previously undergone an endometriosis surgery. All patients underwent face-to-face interviews, thorough preoperative physical examination, and transvaginal ultrasound. Pain severity was assessed preoperatively through an 11-point numerical rating scale. The association of SUP with gynecologic symptoms was adjusted for potential confounders using multivariable logistic regression. The presence of SUP was associated with lower body weight (59.8 vs. 63.5 kg) and body mass index (21.8 vs. 23.3 kg/m2), and a higher frequency of smoking habit (41.6% vs. 32.8%) and of positive familial history of endometriosis (7.0% vs. 2.3%). Moreover, SUP was associated with an increased risk of primary infertility (adjusted prevalence ratio [PR] 1.83, 95% confidence interval [CI] 1.46-2.24), moderate to intense dysmenorrhea (PR 1.43, 95% CI 1.31-1.52), and moderate to intense deep dyspareunia (PR 1.50, 95% CI 1.25-1.75). In conclusion, in this large surgical series, isolated SUP was independently associated to primary infertility and moderate to severe painful symptoms.

Authors+Show Affiliations

Department of Gynecology Obstetrics II and Reproductive Medicine (Professor Chapron), Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité; and Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Paris, France. Department of Obstetrics and Gynecology, University of Minas Gerais, and National Institute of Hormones and Women's Health, Belo Horizonte, Brazil. Department "Development, Reproduction and Cancer", Institut Cochin, INSERM U1016 (Professor Batteux), Université Paris Descartes, Sorbonne Paris Cité, Paris, France.Department of Gynecology Obstetrics II and Reproductive Medicine (Professor Chapron), Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité; and Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Paris, France. Department "Development, Reproduction and Cancer", Institut Cochin, INSERM U1016 (Professor Batteux), Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Department "Development, Reproduction and Cancer", Institut Cochin, INSERM U1016 (Doctor Vaiman), Université Paris Descartes, Sorbonne Paris Cité, Paris, France.Department of Gynecology Obstetrics II and Reproductive Medicine (Professor Chapron), Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité; and Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Paris, France. Department "Development, Reproduction and Cancer", Institut Cochin, INSERM U1016 (Professor Batteux), Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Department "Development, Reproduction and Cancer", Institut Cochin, INSERM U1016 (Doctor Vaiman), Université Paris Descartes, Sorbonne Paris Cité, Paris, France.Department of Gynecology Obstetrics II and Reproductive Medicine (Professor Chapron), Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité; and Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Paris, France. Department "Development, Reproduction and Cancer", Institut Cochin, INSERM U1016 (Doctor Vaiman), Université Paris Descartes, Sorbonne Paris Cité, Paris, France.Department of Gynecology Obstetrics II and Reproductive Medicine (Professor Chapron), Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité; and Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Paris, France.Department of Gynecology Obstetrics II and Reproductive Medicine (Professor Chapron), Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité; and Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Paris, France. charles.chapron@aphp.fr. Department "Development, Reproduction and Cancer", Institut Cochin, INSERM U1016 (Professor Batteux), Université Paris Descartes, Sorbonne Paris Cité, Paris, France. charles.chapron@aphp.fr. Department "Development, Reproduction and Cancer", Institut Cochin, INSERM U1016 (Doctor Vaiman), Université Paris Descartes, Sorbonne Paris Cité, Paris, France. charles.chapron@aphp.fr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32046376

Citation

Reis, Fernando M., et al. "Superficial Peritoneal Endometriosis: Clinical Characteristics of 203 Confirmed Cases and 1292 Endometriosis-Free Controls." Reproductive Sciences (Thousand Oaks, Calif.), vol. 27, no. 1, 2020, pp. 309-315.
Reis FM, Santulli P, Marcellin L, et al. Superficial Peritoneal Endometriosis: Clinical Characteristics of 203 Confirmed Cases and 1292 Endometriosis-Free Controls. Reprod Sci. 2020;27(1):309-315.
Reis, F. M., Santulli, P., Marcellin, L., Borghese, B., Lafay-Pillet, M. C., & Chapron, C. (2020). Superficial Peritoneal Endometriosis: Clinical Characteristics of 203 Confirmed Cases and 1292 Endometriosis-Free Controls. Reproductive Sciences (Thousand Oaks, Calif.), 27(1), 309-315. https://doi.org/10.1007/s43032-019-00028-1
Reis FM, et al. Superficial Peritoneal Endometriosis: Clinical Characteristics of 203 Confirmed Cases and 1292 Endometriosis-Free Controls. Reprod Sci. 2020;27(1):309-315. PubMed PMID: 32046376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Superficial Peritoneal Endometriosis: Clinical Characteristics of 203 Confirmed Cases and 1292 Endometriosis-Free Controls. AU - Reis,Fernando M, AU - Santulli,Pietro, AU - Marcellin,Louis, AU - Borghese,Bruno, AU - Lafay-Pillet,Marie-Christine, AU - Chapron,Charles, Y1 - 2020/01/01/ PY - 2019/01/22/received PY - 2019/04/01/accepted PY - 2020/2/13/pubmed PY - 2020/2/13/medline PY - 2020/2/13/entrez KW - Dysmenorrhea KW - Endometriosis KW - Infertility KW - Pelvic pain KW - Superficial peritoneal SP - 309 EP - 315 JF - Reproductive sciences (Thousand Oaks, Calif.) JO - Reprod Sci VL - 27 IS - 1 N2 - The aim of this study was to characterize a large sample of women with superficial peritoneal endometriosis (SUP) and no other types of endometriosis in order to test the association of SUP with gynecologic symptoms. We included 203 cases of histologically proven SUP and 1292 endometriosis-free controls diagnosed between January 2004 and July 2017. The participants were non-pregnant patients aged 18 to 42 years submitted to a laparoscopy or laparotomy for a benign gynecologic condition. We excluded all cases of ovarian endometrioma, deep infiltrating endometriosis, and women who had previously undergone an endometriosis surgery. All patients underwent face-to-face interviews, thorough preoperative physical examination, and transvaginal ultrasound. Pain severity was assessed preoperatively through an 11-point numerical rating scale. The association of SUP with gynecologic symptoms was adjusted for potential confounders using multivariable logistic regression. The presence of SUP was associated with lower body weight (59.8 vs. 63.5 kg) and body mass index (21.8 vs. 23.3 kg/m2), and a higher frequency of smoking habit (41.6% vs. 32.8%) and of positive familial history of endometriosis (7.0% vs. 2.3%). Moreover, SUP was associated with an increased risk of primary infertility (adjusted prevalence ratio [PR] 1.83, 95% confidence interval [CI] 1.46-2.24), moderate to intense dysmenorrhea (PR 1.43, 95% CI 1.31-1.52), and moderate to intense deep dyspareunia (PR 1.50, 95% CI 1.25-1.75). In conclusion, in this large surgical series, isolated SUP was independently associated to primary infertility and moderate to severe painful symptoms. SN - 1933-7205 UR - https://www.unboundmedicine.com/medline/citation/32046376/Superficial_Peritoneal_Endometriosis:_Clinical_Characteristics_of_203_Confirmed_Cases_and_1292_Endometriosis_Free_Controls_ L2 - https://doi.org/10.1007/s43032-019-00028-1 DB - PRIME DP - Unbound Medicine ER -