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Laparoscopic Ovarian Drilling Improves Endometrial Homeobox Gene Expression in PCOS.
Reprod Sci. 2020 02; 27(2):675-680.RS

Abstract

The study was designed to investigate whether laparoscopic ovarian drilling (LOD) of ovaries alters the expression levels of HOXA-10 and HOXA-11 mRNA in the endometrium of infertile women with clomiphene-resistant PCOS. Expression of HOXA-10 and HOXA-11 mRNA in the endometrium obtained before and after LOD during the midsecretory phase was measured. Expression of each gene was evaluated using real-time reverse transcriptase polymerase chain reaction (RT-PCR). Expression levels of HOXA-10 and HOXA-11 mRNA were lower in endometrium of patients with PCOS before LOD compared with fertile controls. But the differences failed to show statistical significance. Compared with fertile subjects, LOD of PCOS ovaries up-regulated endometrial HOXA-10 and HOXA-11 mRNA expression. Fold changes of HOXA-10 and HOXA-11 mRNA after LOD were found to be 4.46 and 4.19, respectively. Fold change increase in HOXA-10 and HOXA-11 mRNA was found to be statistically significant (P < .01, P < .02). There is a receptivity defect in the endometrium of women with PCOS that affects fertility regardless of other causes of infertility. LOD increases endometrial HOXA-10 and HOXA-11 mRNA expressions and improves receptivity in patients with clomiphene-resistant PCOS.

Authors+Show Affiliations

Faculty of Medicine, Department of Obstetrics and Gynecology, Recep Tayyip Erdogan University, Rize, Turkey.Private Clinic, Obstetrics and Gynecology, Usak, Turkey. celiksudenaz@gmail.com.Faculty of Science, Department of Biology Molecular Biology and Genetics, Fırat University, Elazig, Turkey.Medicana Samsun International Hospital IVF Unit, Samsun, Turkey.Department of Biochemistry, Behcet Uz Children's Hospital, Izmir, Turkey.Department of Obstetrics and Gynecology, School of Medicine, Acıbadem University, Istanbul, Turkey.Department of Medical Microbiology, School of Medicine, Inonu University, Malatya, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32046414

Citation

Senturk, Senol, et al. "Laparoscopic Ovarian Drilling Improves Endometrial Homeobox Gene Expression in PCOS." Reproductive Sciences (Thousand Oaks, Calif.), vol. 27, no. 2, 2020, pp. 675-680.
Senturk S, Celik O, Dalkilic S, et al. Laparoscopic Ovarian Drilling Improves Endometrial Homeobox Gene Expression in PCOS. Reprod Sci. 2020;27(2):675-680.
Senturk, S., Celik, O., Dalkilic, S., Hatirnaz, S., Celik, N., Unlu, C., & Otlu, B. (2020). Laparoscopic Ovarian Drilling Improves Endometrial Homeobox Gene Expression in PCOS. Reproductive Sciences (Thousand Oaks, Calif.), 27(2), 675-680. https://doi.org/10.1007/s43032-019-00072-x
Senturk S, et al. Laparoscopic Ovarian Drilling Improves Endometrial Homeobox Gene Expression in PCOS. Reprod Sci. 2020;27(2):675-680. PubMed PMID: 32046414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laparoscopic Ovarian Drilling Improves Endometrial Homeobox Gene Expression in PCOS. AU - Senturk,Senol, AU - Celik,Onder, AU - Dalkilic,Semih, AU - Hatirnaz,Safak, AU - Celik,Nilufer, AU - Unlu,Cihat, AU - Otlu,Baris, Y1 - 2020/01/01/ PY - 2019/03/27/received PY - 2019/08/26/accepted PY - 2020/2/13/pubmed PY - 2020/2/13/medline PY - 2020/2/13/entrez KW - HOXA gene KW - Ovarian drilling KW - PCOS KW - Receptivity SP - 675 EP - 680 JF - Reproductive sciences (Thousand Oaks, Calif.) JO - Reprod Sci VL - 27 IS - 2 N2 - The study was designed to investigate whether laparoscopic ovarian drilling (LOD) of ovaries alters the expression levels of HOXA-10 and HOXA-11 mRNA in the endometrium of infertile women with clomiphene-resistant PCOS. Expression of HOXA-10 and HOXA-11 mRNA in the endometrium obtained before and after LOD during the midsecretory phase was measured. Expression of each gene was evaluated using real-time reverse transcriptase polymerase chain reaction (RT-PCR). Expression levels of HOXA-10 and HOXA-11 mRNA were lower in endometrium of patients with PCOS before LOD compared with fertile controls. But the differences failed to show statistical significance. Compared with fertile subjects, LOD of PCOS ovaries up-regulated endometrial HOXA-10 and HOXA-11 mRNA expression. Fold changes of HOXA-10 and HOXA-11 mRNA after LOD were found to be 4.46 and 4.19, respectively. Fold change increase in HOXA-10 and HOXA-11 mRNA was found to be statistically significant (P < .01, P < .02). There is a receptivity defect in the endometrium of women with PCOS that affects fertility regardless of other causes of infertility. LOD increases endometrial HOXA-10 and HOXA-11 mRNA expressions and improves receptivity in patients with clomiphene-resistant PCOS. SN - 1933-7205 UR - https://www.unboundmedicine.com/medline/citation/32046414/Laparoscopic_Ovarian_Drilling_Improves_Endometrial_Homeobox_Gene_Expression_in_PCOS L2 - https://journals.sagepub.com/doi/10.1007/s43032-019-00072-x?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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