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Biomarkers of inflammation and oxidative stress in ophthalmic disorders.
J Immunoassay Immunochem. 2020 May 03; 41(3):257-271.JI

Abstract

The review article focuses on free radicals and oxidative stress involved in ophthalmological diseases such as retinopathy, cataract, glaucoma, etc. Oxidative stress is considered as a key factor involved in the pathology of many chronic diseases including ophthalmic complication and inflammatory process. Oxidative stress and inflammation are closely related pathophysiological processes and are simultaneously found in many pathological conditions. The free radicals produced oxidize cellular components such as lipids and phospholipids leading to lipid peroxidation and trigger the onset of retinopathy. Cataract is a significant cause of visual disability and it is proposed that the high incidence is related to oxidative stress induced by continued intraocular penetration of light and consequent photochemical generation of free radical oxidants. Glaucoma is the leading cause of irreversible blindness and comprises a group of diseases characterized by progressive optic nerve degeneration. Oxidative injury and altered antioxidant defense mechanisms in glaucoma appear to play a role in the pathophysiology of glaucomatous neurodegeneration that is characterized by death of retinal ganglion cells. The UVB radiations through this way may cause a number of diseases like photo-keratitis, pterygium, damage to epithelium, edema, and corneal cell apoptosis.Abbreviations: ROS: reactive oxygen species; RNS: reactive nitrogen species; O2.: superoxide anion; H2O2: hydrogen peroxide;. OH: hydroxyl radicals; ONOO-, ONO2-: peroxynitrite; NO: nitric oxide; IOP: intraocular pressure; RGC: retinal ganglion cells. WHO: World Health Organization; IAPB: International Agency for the Prevention of Blindness.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, India. Department of Nano-Therapeutics, Institute of Nano Science and Technology, Habitat Centre, Mohali, India.Faculty of Dentistry, Department of Biochemistry, Jamia Millia Islamia, New Delhi, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32046582

Citation

Ahmad, Anas, and Haseeb Ahsan. "Biomarkers of Inflammation and Oxidative Stress in Ophthalmic Disorders." Journal of Immunoassay & Immunochemistry, vol. 41, no. 3, 2020, pp. 257-271.
Ahmad A, Ahsan H. Biomarkers of inflammation and oxidative stress in ophthalmic disorders. J Immunoassay Immunochem. 2020;41(3):257-271.
Ahmad, A., & Ahsan, H. (2020). Biomarkers of inflammation and oxidative stress in ophthalmic disorders. Journal of Immunoassay & Immunochemistry, 41(3), 257-271. https://doi.org/10.1080/15321819.2020.1726774
Ahmad A, Ahsan H. Biomarkers of Inflammation and Oxidative Stress in Ophthalmic Disorders. J Immunoassay Immunochem. 2020 May 3;41(3):257-271. PubMed PMID: 32046582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomarkers of inflammation and oxidative stress in ophthalmic disorders. AU - Ahmad,Anas, AU - Ahsan,Haseeb, Y1 - 2020/02/11/ PY - 2020/2/13/pubmed PY - 2021/1/1/medline PY - 2020/2/13/entrez KW - Oxidative stress KW - cataract KW - diabetic retinopathy KW - free radicals KW - glaucoma KW - vision 2020 SP - 257 EP - 271 JF - Journal of immunoassay & immunochemistry JO - J Immunoassay Immunochem VL - 41 IS - 3 N2 - The review article focuses on free radicals and oxidative stress involved in ophthalmological diseases such as retinopathy, cataract, glaucoma, etc. Oxidative stress is considered as a key factor involved in the pathology of many chronic diseases including ophthalmic complication and inflammatory process. Oxidative stress and inflammation are closely related pathophysiological processes and are simultaneously found in many pathological conditions. The free radicals produced oxidize cellular components such as lipids and phospholipids leading to lipid peroxidation and trigger the onset of retinopathy. Cataract is a significant cause of visual disability and it is proposed that the high incidence is related to oxidative stress induced by continued intraocular penetration of light and consequent photochemical generation of free radical oxidants. Glaucoma is the leading cause of irreversible blindness and comprises a group of diseases characterized by progressive optic nerve degeneration. Oxidative injury and altered antioxidant defense mechanisms in glaucoma appear to play a role in the pathophysiology of glaucomatous neurodegeneration that is characterized by death of retinal ganglion cells. The UVB radiations through this way may cause a number of diseases like photo-keratitis, pterygium, damage to epithelium, edema, and corneal cell apoptosis.Abbreviations: ROS: reactive oxygen species; RNS: reactive nitrogen species; O2.: superoxide anion; H2O2: hydrogen peroxide;. OH: hydroxyl radicals; ONOO-, ONO2-: peroxynitrite; NO: nitric oxide; IOP: intraocular pressure; RGC: retinal ganglion cells. WHO: World Health Organization; IAPB: International Agency for the Prevention of Blindness. SN - 1532-4230 UR - https://www.unboundmedicine.com/medline/citation/32046582/Biomarkers_of_inflammation_and_oxidative_stress_in_ophthalmic_disorders L2 - https://www.tandfonline.com/doi/full/10.1080/15321819.2020.1726774 DB - PRIME DP - Unbound Medicine ER -