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Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing.
Radiology. 2020 08; 296(2):E41-E45.R

Abstract

Some patients with positive chest CT findings may present with negative results of real-time reverse-transcription polymerase chain reaction (RT-PCR) tests for coronavirus disease 2019 (COVID-19). In this study, the authors present chest CT findings from five patients with COVID-19 infection who had initial negative RT-PCR results. All five patients had typical imaging findings, including ground-glass opacity (five patients) and/or mixed ground-glass opacity and mixed consolidation (two patients). After isolation for presumed COVID-19 pneumonia, all patients were eventually confirmed to have COVID-19 infection by means of repeated swab tests. A combination of repeated swab tests and CT scanning may be helpful for individuals with a high clinical suspicion of COVID-19 infection but negative findings at RT-PCR screening.

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Authors+Show Affiliations

Xie X
From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).
Zhong Z
From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).
Zhao W
From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).
Zheng C
From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).
Wang F
From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).
Liu J
From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).

MeSH

AdultAgedBetacoronavirusCOVID-19COVID-19 TestingCOVID-19 VaccinesClinical Laboratory TechniquesCoronavirus InfectionsFalse Negative ReactionsFemaleHumansMaleMiddle AgedPandemicsPneumonia, ViralRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionSARS-CoV-2Tomography, X-Ray Computed

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32049601

Clinical Trial Links

Clinical, Functional, Immunological and Genetic Factors on the Severity of the Course of Coronavirus Infection
Lung CT Scan Analysis of SARS-CoV2 Induced Lung Injury
Determinants of COVID-19 Pneumonia (MC-19)

Citation

Xie, Xingzhi, et al. "Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing." Radiology, vol. 296, no. 2, 2020, pp. E41-E45.
Xie X, Zhong Z, Zhao W, et al. Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing. Radiology. 2020;296(2):E41-E45.
Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., & Liu, J. (2020). Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing. Radiology, 296(2), E41-E45. https://doi.org/10.1148/radiol.2020200343
Xie X, et al. Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing. Radiology. 2020;296(2):E41-E45. PubMed PMID: 32049601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing. AU - Xie,Xingzhi, AU - Zhong,Zheng, AU - Zhao,Wei, AU - Zheng,Chao, AU - Wang,Fei, AU - Liu,Jun, Y1 - 2020/02/12/ PY - 2020/2/13/pubmed PY - 2020/8/1/medline PY - 2020/2/13/entrez SP - E41 EP - E45 JF - Radiology JO - Radiology VL - 296 IS - 2 N2 - Some patients with positive chest CT findings may present with negative results of real-time reverse-transcription polymerase chain reaction (RT-PCR) tests for coronavirus disease 2019 (COVID-19). In this study, the authors present chest CT findings from five patients with COVID-19 infection who had initial negative RT-PCR results. All five patients had typical imaging findings, including ground-glass opacity (five patients) and/or mixed ground-glass opacity and mixed consolidation (two patients). After isolation for presumed COVID-19 pneumonia, all patients were eventually confirmed to have COVID-19 infection by means of repeated swab tests. A combination of repeated swab tests and CT scanning may be helpful for individuals with a high clinical suspicion of COVID-19 infection but negative findings at RT-PCR screening. SN - 1527-1315 UR - https://www.unboundmedicine.com/medline/citation/32049601/full_citation DB - PRIME DP - Unbound Medicine ER -