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Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing.
Radiology. 2020 08; 296(2):E41-E45.R

Abstract

Some patients with positive chest CT findings may present with negative results of real-time reverse-transcription polymerase chain reaction (RT-PCR) tests for coronavirus disease 2019 (COVID-19). In this study, the authors present chest CT findings from five patients with COVID-19 infection who had initial negative RT-PCR results. All five patients had typical imaging findings, including ground-glass opacity (five patients) and/or mixed ground-glass opacity and mixed consolidation (two patients). After isolation for presumed COVID-19 pneumonia, all patients were eventually confirmed to have COVID-19 infection by means of repeated swab tests. A combination of repeated swab tests and CT scanning may be helpful for individuals with a high clinical suspicion of COVID-19 infection but negative findings at RT-PCR screening.

Authors+Show Affiliations

From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).From the Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Rd, Changsha, Hunan Province, 410011, P.R. China (X.X., W.Z., J.L.); Department of Radiology, Quality Control Center, Changsha, China (J.L.); Department of Radiology, First Hospital of Changsha, China (Z.Z.); Changsha Public Health Treatment Center, Changsha, China (Z.Z.); Department of Radiology, The First People's Hospital of Changde City, Changde, China (C.Z.); and Department of Radiology, The Second People's Hospital of Changde City, Changde, China (F.W.).

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32049601

Citation

Xie, Xingzhi, et al. "Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing." Radiology, vol. 296, no. 2, 2020, pp. E41-E45.
Xie X, Zhong Z, Zhao W, et al. Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing. Radiology. 2020;296(2):E41-E45.
Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., & Liu, J. (2020). Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing. Radiology, 296(2), E41-E45. https://doi.org/10.1148/radiol.2020200343
Xie X, et al. Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing. Radiology. 2020;296(2):E41-E45. PubMed PMID: 32049601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing. AU - Xie,Xingzhi, AU - Zhong,Zheng, AU - Zhao,Wei, AU - Zheng,Chao, AU - Wang,Fei, AU - Liu,Jun, Y1 - 2020/02/12/ PY - 2020/2/13/pubmed PY - 2020/8/1/medline PY - 2020/2/13/entrez SP - E41 EP - E45 JF - Radiology JO - Radiology VL - 296 IS - 2 N2 - Some patients with positive chest CT findings may present with negative results of real-time reverse-transcription polymerase chain reaction (RT-PCR) tests for coronavirus disease 2019 (COVID-19). In this study, the authors present chest CT findings from five patients with COVID-19 infection who had initial negative RT-PCR results. All five patients had typical imaging findings, including ground-glass opacity (five patients) and/or mixed ground-glass opacity and mixed consolidation (two patients). After isolation for presumed COVID-19 pneumonia, all patients were eventually confirmed to have COVID-19 infection by means of repeated swab tests. A combination of repeated swab tests and CT scanning may be helpful for individuals with a high clinical suspicion of COVID-19 infection but negative findings at RT-PCR screening. SN - 1527-1315 UR - https://www.unboundmedicine.com/medline/citation/32049601/full_citation L2 - https://pubs.rsna.org/doi/10.1148/radiol.2020200343?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -