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Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing.
Radiology. 2020 Feb 12 [Online ahead of print]R

Abstract

Some patients with positive chest CT findings may present with negative results of real time reverse-transcription-polymerase chain- reaction (RT-PCR) for 2019 novel coronavirus (2019-nCoV). In this report, we present chest CT findings from five patients with 2019-nCoV infection who had initial negative RT-PCR results. All five patients had typical imaging findings, including ground-glass opacity (GGO) (5 patients) and/or mixed GGO and mixed consolidation (2 patients). After isolation for presumed 2019-nCoV pneumonia, all patients were eventually confirmed with 2019-nCoV infection by repeated swab tests. A combination of repeated swab tests and CT scanning may be helpful when for individuals with high clinical suspicion of nCoV infection but negative RT-PCR screening.

Authors+Show Affiliations

From the Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China (X.X., W.Z., J.L.); Department of Radiology Quality Control Center, Changsha, Hunan Province, 410011, China (J.L.); Department of Radiology, First hospital of Changsha, Hunan Province, 410005, China (Z.Z.); Changsha public health treatment center, Hunan Province, 410153, China (Z.Z.); Department of Radiology,The first people's hospital of Changde city, Hunan Province,415003,China (C.Z.); and Department of Radiology,The second people's hospital of Changde city, Hunan Province,415001,China (F.W.).From the Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China (X.X., W.Z., J.L.); Department of Radiology Quality Control Center, Changsha, Hunan Province, 410011, China (J.L.); Department of Radiology, First hospital of Changsha, Hunan Province, 410005, China (Z.Z.); Changsha public health treatment center, Hunan Province, 410153, China (Z.Z.); Department of Radiology,The first people's hospital of Changde city, Hunan Province,415003,China (C.Z.); and Department of Radiology,The second people's hospital of Changde city, Hunan Province,415001,China (F.W.).From the Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China (X.X., W.Z., J.L.); Department of Radiology Quality Control Center, Changsha, Hunan Province, 410011, China (J.L.); Department of Radiology, First hospital of Changsha, Hunan Province, 410005, China (Z.Z.); Changsha public health treatment center, Hunan Province, 410153, China (Z.Z.); Department of Radiology,The first people's hospital of Changde city, Hunan Province,415003,China (C.Z.); and Department of Radiology,The second people's hospital of Changde city, Hunan Province,415001,China (F.W.).From the Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China (X.X., W.Z., J.L.); Department of Radiology Quality Control Center, Changsha, Hunan Province, 410011, China (J.L.); Department of Radiology, First hospital of Changsha, Hunan Province, 410005, China (Z.Z.); Changsha public health treatment center, Hunan Province, 410153, China (Z.Z.); Department of Radiology,The first people's hospital of Changde city, Hunan Province,415003,China (C.Z.); and Department of Radiology,The second people's hospital of Changde city, Hunan Province,415001,China (F.W.).From the Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China (X.X., W.Z., J.L.); Department of Radiology Quality Control Center, Changsha, Hunan Province, 410011, China (J.L.); Department of Radiology, First hospital of Changsha, Hunan Province, 410005, China (Z.Z.); Changsha public health treatment center, Hunan Province, 410153, China (Z.Z.); Department of Radiology,The first people's hospital of Changde city, Hunan Province,415003,China (C.Z.); and Department of Radiology,The second people's hospital of Changde city, Hunan Province,415001,China (F.W.).From the Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, China (X.X., W.Z., J.L.); Department of Radiology Quality Control Center, Changsha, Hunan Province, 410011, China (J.L.); Department of Radiology, First hospital of Changsha, Hunan Province, 410005, China (Z.Z.); Changsha public health treatment center, Hunan Province, 410153, China (Z.Z.); Department of Radiology,The first people's hospital of Changde city, Hunan Province,415003,China (C.Z.); and Department of Radiology,The second people's hospital of Changde city, Hunan Province,415001,China (F.W.).

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32049601

Citation

Xie, Xingzhi, et al. "Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing." Radiology, 2020, p. 200343.
Xie X, Zhong Z, Zhao W, et al. Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing. Radiology. 2020.
Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., & Liu, J. (2020). Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing. Radiology, 200343. https://doi.org/10.1148/radiol.2020200343
Xie X, et al. Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing. Radiology. 2020 Feb 12;200343. PubMed PMID: 32049601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing. AU - Xie,Xingzhi, AU - Zhong,Zheng, AU - Zhao,Wei, AU - Zheng,Chao, AU - Wang,Fei, AU - Liu,Jun, Y1 - 2020/02/12/ PY - 2020/2/13/entrez PY - 2020/2/13/pubmed PY - 2020/2/13/medline SP - 200343 EP - 200343 JF - Radiology JO - Radiology N2 - Some patients with positive chest CT findings may present with negative results of real time reverse-transcription-polymerase chain- reaction (RT-PCR) for 2019 novel coronavirus (2019-nCoV). In this report, we present chest CT findings from five patients with 2019-nCoV infection who had initial negative RT-PCR results. All five patients had typical imaging findings, including ground-glass opacity (GGO) (5 patients) and/or mixed GGO and mixed consolidation (2 patients). After isolation for presumed 2019-nCoV pneumonia, all patients were eventually confirmed with 2019-nCoV infection by repeated swab tests. A combination of repeated swab tests and CT scanning may be helpful when for individuals with high clinical suspicion of nCoV infection but negative RT-PCR screening. SN - 1527-1315 UR - https://www.unboundmedicine.com/medline/citation/32049601/full_citation L2 - http://pubs.rsna.org/doi/10.1148/radiol.2020200343?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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