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[Typhoid and paratyphoid fever].
Z Gastroenterol. 2020 Feb; 58(2):160-170.ZG

Abstract

Typhoid fever and paratyphoid fever are systemic infectious diseases of global significance caused by Salmonella enterica subspecies enterica Serovar Typhi (short name: Salmonella Typhi) or Serovar Paratyphi (short name: Salmonella Paratyphi). The course of these fecal-orally transmitted diseases is mainly characterized by a high fever. Left untreated, the course of typhoid fever can be severe and lethal. The infection is almost always acquired outside of Europe (mainly in India) and is notifiable in Germany, Austria and Switzerland. Paratyphoid is an attenuated disease of typhoid fever caused by Salmonella Paratyphi. Available vaccines only protect against Salmonella Typhi. Antibiotic resistance reflects the situation in endemic countries and shows a worrying increase of multi-drug resistant isolates. Currently, third-generation cephalosporins such as ceftriaxone are recommended as first-line therapy; if sensitive to quinolones, fluoroquinolones such as ciprofloxacin may continue to be administered. Crucial preventive measures for travelers to endemic regions include consistent water and food hygiene as well as vaccination, whereby only protection rates of 50-70 % are achieved by currently available vaccines. In the light of increasing multi-drug resistance, a more effective conjugate vaccine against Salmonella Typhi with cross-reactivity against Salmonella Paratyphi is needed more than ever.

Authors+Show Affiliations

Bereich Infektions- und Tropenmedizin, Klinik und Poliklinik für Gastroenterologie, Hepatologie, Infektiologie, Pneumologie, Universitätsklinikum Leipzig. Interdisziplinäres Zentrum für Infektionsmedizin (ZINF), Universitätsklinikum Leipzig.Bereich Infektions- und Tropenmedizin, Klinik und Poliklinik für Gastroenterologie, Hepatologie, Infektiologie, Pneumologie, Universitätsklinikum Leipzig. Interdisziplinäres Zentrum für Infektionsmedizin (ZINF), Universitätsklinikum Leipzig. Institut für Medizinische Mikrobiologie und Infektionsepidemiologie, Universitätsklinikum Leipzig.Institut für Medizinische Mikrobiologie und Infektionsepidemiologie, Universitätsklinikum Leipzig.Bereich Infektions- und Tropenmedizin, Klinik und Poliklinik für Gastroenterologie, Hepatologie, Infektiologie, Pneumologie, Universitätsklinikum Leipzig. Klinik und Poliklinik für Endokrinologie, Nephrologie, Rheumatologie, Universitätsklinikum Leipzig. Helmholtz-Institut für Metabolismus-, Adipositas- und Gefäβforschung München an der Universität Leipzig und dem Universitätsklinikum Leipzig.Bereich Infektions- und Tropenmedizin, Klinik und Poliklinik für Gastroenterologie, Hepatologie, Infektiologie, Pneumologie, Universitätsklinikum Leipzig. Interdisziplinäres Zentrum für Infektionsmedizin (ZINF), Universitätsklinikum Leipzig.Bereich Infektions- und Tropenmedizin, Klinik und Poliklinik für Gastroenterologie, Hepatologie, Infektiologie, Pneumologie, Universitätsklinikum Leipzig. Interdisziplinäres Zentrum für Infektionsmedizin (ZINF), Universitätsklinikum Leipzig.

Pub Type(s)

Journal Article
Review

Language

ger

PubMed ID

32050286

Citation

Trawinski, Henning, et al. "[Typhoid and Paratyphoid Fever]." Zeitschrift Fur Gastroenterologie, vol. 58, no. 2, 2020, pp. 160-170.
Trawinski H, Wendt S, Lippmann N, et al. [Typhoid and paratyphoid fever]. Z Gastroenterol. 2020;58(2):160-170.
Trawinski, H., Wendt, S., Lippmann, N., Heinitz, S., von Braun, A., & Lübbert, C. (2020). [Typhoid and paratyphoid fever]. Zeitschrift Fur Gastroenterologie, 58(2), 160-170. https://doi.org/10.1055/a-1063-1945
Trawinski H, et al. [Typhoid and Paratyphoid Fever]. Z Gastroenterol. 2020;58(2):160-170. PubMed PMID: 32050286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Typhoid and paratyphoid fever]. AU - Trawinski,Henning, AU - Wendt,Sebastian, AU - Lippmann,Norman, AU - Heinitz,Sascha, AU - von Braun,Amrei, AU - Lübbert,Christoph, Y1 - 2020/02/12/ PY - 2020/2/13/entrez PY - 2020/2/13/pubmed PY - 2020/3/7/medline SP - 160 EP - 170 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 58 IS - 2 N2 - Typhoid fever and paratyphoid fever are systemic infectious diseases of global significance caused by Salmonella enterica subspecies enterica Serovar Typhi (short name: Salmonella Typhi) or Serovar Paratyphi (short name: Salmonella Paratyphi). The course of these fecal-orally transmitted diseases is mainly characterized by a high fever. Left untreated, the course of typhoid fever can be severe and lethal. The infection is almost always acquired outside of Europe (mainly in India) and is notifiable in Germany, Austria and Switzerland. Paratyphoid is an attenuated disease of typhoid fever caused by Salmonella Paratyphi. Available vaccines only protect against Salmonella Typhi. Antibiotic resistance reflects the situation in endemic countries and shows a worrying increase of multi-drug resistant isolates. Currently, third-generation cephalosporins such as ceftriaxone are recommended as first-line therapy; if sensitive to quinolones, fluoroquinolones such as ciprofloxacin may continue to be administered. Crucial preventive measures for travelers to endemic regions include consistent water and food hygiene as well as vaccination, whereby only protection rates of 50-70 % are achieved by currently available vaccines. In the light of increasing multi-drug resistance, a more effective conjugate vaccine against Salmonella Typhi with cross-reactivity against Salmonella Paratyphi is needed more than ever. SN - 1439-7803 UR - https://www.unboundmedicine.com/medline/citation/32050286/[Typhoid_and_paratyphoid_fever]_ DB - PRIME DP - Unbound Medicine ER -