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Potential Maternal and Infant Outcomes from (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections.
Viruses. 2020 02 10; 12(2)V

Abstract

In early December 2019 a cluster of cases of pneumonia of unknown cause was identified in Wuhan, a city of 11 million persons in the People's Republic of China. Further investigation revealed these cases to result from infection with a newly identified coronavirus, termed the 2019-nCoV. The infection moved rapidly through China, spread to Thailand and Japan, extended into adjacent countries through infected persons travelling by air, eventually reaching multiple countries and continents. Similar to such other coronaviruses as those causing the Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS), the new coronavirus was reported to spread via natural aerosols from human-to-human. In the early stages of this epidemic the case fatality rate is estimated to be approximately 2%, with the majority of deaths occurring in special populations. Unfortunately, there is limited experience with coronavirus infections during pregnancy, and it now appears certain that pregnant women have become infected during the present 2019-nCoV epidemic. In order to assess the potential of the Wuhan 2019-nCoV to cause maternal, fetal and neonatal morbidity and other poor obstetrical outcomes, this communication reviews the published data addressing the epidemiological and clinical effects of SARS, MERS, and other coronavirus infections on pregnant women and their infants. Recommendations are also made for the consideration of pregnant women in the design, clinical trials, and implementation of future 2019-nCoV vaccines.

Authors+Show Affiliations

Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.Department of Anthropology, University of Connecticut, Storrs, CT 06269, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32050635

Citation

Schwartz, David A., and Ashley L. Graham. "Potential Maternal and Infant Outcomes From (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons From SARS, MERS, and Other Human Coronavirus Infections." Viruses, vol. 12, no. 2, 2020.
Schwartz DA, Graham AL. Potential Maternal and Infant Outcomes from (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections. Viruses. 2020;12(2).
Schwartz, D. A., & Graham, A. L. (2020). Potential Maternal and Infant Outcomes from (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections. Viruses, 12(2). https://doi.org/10.3390/v12020194
Schwartz DA, Graham AL. Potential Maternal and Infant Outcomes From (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons From SARS, MERS, and Other Human Coronavirus Infections. Viruses. 2020 02 10;12(2) PubMed PMID: 32050635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential Maternal and Infant Outcomes from (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections. AU - Schwartz,David A, AU - Graham,Ashley L, Y1 - 2020/02/10/ PY - 2020/02/02/received PY - 2020/02/09/revised PY - 2020/02/09/accepted PY - 2020/2/14/entrez PY - 2020/2/14/pubmed PY - 2020/3/24/medline KW - 2019-nCoV KW - China KW - MERS-CoV KW - Middle East respiratory syndrome KW - SARS-CoV KW - Wuhan coronavirus KW - Wuhan coronavirus outbreak KW - coronavirus KW - emerging infection KW - epidemic KW - maternal death KW - maternal morbidity KW - maternal mortality KW - pneumonia KW - pregnancy KW - pregnancy complications KW - severe acute respiratory syndrome JF - Viruses JO - Viruses VL - 12 IS - 2 N2 - In early December 2019 a cluster of cases of pneumonia of unknown cause was identified in Wuhan, a city of 11 million persons in the People's Republic of China. Further investigation revealed these cases to result from infection with a newly identified coronavirus, termed the 2019-nCoV. The infection moved rapidly through China, spread to Thailand and Japan, extended into adjacent countries through infected persons travelling by air, eventually reaching multiple countries and continents. Similar to such other coronaviruses as those causing the Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS), the new coronavirus was reported to spread via natural aerosols from human-to-human. In the early stages of this epidemic the case fatality rate is estimated to be approximately 2%, with the majority of deaths occurring in special populations. Unfortunately, there is limited experience with coronavirus infections during pregnancy, and it now appears certain that pregnant women have become infected during the present 2019-nCoV epidemic. In order to assess the potential of the Wuhan 2019-nCoV to cause maternal, fetal and neonatal morbidity and other poor obstetrical outcomes, this communication reviews the published data addressing the epidemiological and clinical effects of SARS, MERS, and other coronavirus infections on pregnant women and their infants. Recommendations are also made for the consideration of pregnant women in the design, clinical trials, and implementation of future 2019-nCoV vaccines. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/32050635/Potential_Maternal_and_Infant_Outcomes_from__Wuhan__Coronavirus_2019_nCoV_Infecting_Pregnant_Women:_Lessons_from_SARS_MERS_and_Other_Human_Coronavirus_Infections_ L2 - http://www.mdpi.com/resolver?pii=v12020194 DB - PRIME DP - Unbound Medicine ER -