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Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR.
J Korean Med Sci. 2020 Feb 17; 35(6):e79.JK

Abstract

Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.

Links

  • PMC Free PDF
    • Publisher Full Text
    ncbi.nlm.nih.gov
    jkms.org

    Authors+Show Affiliations

    Lim J
    Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.
    Jeon S
    New Horizon Cancer Institute, Myongji Hospital, Goyang, Korea.
    Shin HY
    Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.
    Kim MJ
    Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.
    Seong YM
    Department of Internal Medicine, Myongji Hospital, Goyang, Korea.
    Lee WJ
    Office of Chief Executive Officer and Chairman, Department of General Surgery, Myongji Hospital, Goyang, Korea.
    Choe KW
    Department of Infectious Diseases, Myongji Hospital, Goyang, Korea.
    Kang YM
    Department of Infectious Diseases, Myongji Hospital, Goyang, Korea.
    Lee B
    CancerROP, Seoul, Korea. baeckseung@gmail.com.
    Park SJ
    Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang, Korea. drjoseph@mjh.or.kr.

    MeSH

    BetacoronavirusChinaCoronavirus InfectionsCytochrome P-450 CYP3A InhibitorsDrug CombinationsHumansLopinavirMaleMiddle AgedPneumoniaPneumonia, ViralReal-Time Polymerase Chain ReactionRepublic of KoreaRitonavirViral Load

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    32056407

    Citation

    Lim, Jaegyun, et al. "Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored By Quantitative RT-PCR." Journal of Korean Medical Science, vol. 35, no. 6, 2020, pp. e79.
    Lim J, Jeon S, Shin HY, et al. Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR. J Korean Med Sci. 2020;35(6):e79.
    Lim, J., Jeon, S., Shin, H. Y., Kim, M. J., Seong, Y. M., Lee, W. J., Choe, K. W., Kang, Y. M., Lee, B., & Park, S. J. (2020). Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR. Journal of Korean Medical Science, 35(6), e79. https://doi.org/10.3346/jkms.2020.35.e79
    Lim J, et al. Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored By Quantitative RT-PCR. J Korean Med Sci. 2020 Feb 17;35(6):e79. PubMed PMID: 32056407.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR. AU - Lim,Jaegyun, AU - Jeon,Seunghyun, AU - Shin,Hyun Young, AU - Kim,Moon Jung, AU - Seong,Yu Min, AU - Lee,Wang Jun, AU - Choe,Kang Won, AU - Kang,Yu Min, AU - Lee,Baeckseung, AU - Park,Sang Joon, Y1 - 2020/02/17/ PY - 2020/02/10/received PY - 2020/02/11/accepted PY - 2020/2/15/entrez PY - 2020/2/15/pubmed PY - 2020/3/17/medline KW - COVID-19 KW - Coronavirus KW - Pneumonia KW - Real-Time Reverse-Transcriptase Polymerase Chain Reaction KW - Tertiary Infection KW - Viral Load SP - e79 EP - e79 JF - Journal of Korean medical science JO - J. Korean Med. Sci. VL - 35 IS - 6 N2 - Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/32056407/full_citation L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2020.35.e79 DB - PRIME DP - Unbound Medicine ER -