Tags

Type your tag names separated by a space and hit enter

Determination of the glomerular filtration rate in patients with type 2 diabetes: An assessment of the agreement between 51Cr-EDTA plasma clearance and 99mTc-DTPA plasma clearance, 99mTc-DTPA renography and plasma creatinine prediction equation.
Diabetes Res Clin Pract. 2020 Mar; 161:108079.DR

Abstract

AIMS

To investigate the agreement of glomerular filtration rate (GFR) determination between 51Cr-ethylenediaminetetraacetic acid (51Cr-EDTA) plasma clearance (GFREDTA) and 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) plasma clearance (GFRDTPA), the Gates 99mTc-DTPA renographic method (GFRGates) and the serum creatinine Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI, GFRSCr) in patients with type 2 diabetes mellitus (T2DM).

METHODS

Ninety-nine T2DM patients underwent GFR determinations simultaneously with 51Cr-EDTA and 99mTc-DTPA (using the slope-intercept technique and the Brochner-Mortensen correction) and also with GFRGates and GFRSCr.

RESULTS

In the comparison between GFREDTA versus GFRDTPA, GFRGates and GFRSCr, the Bland-Altman statistic provided 0.0 ± 13.2, 17.4* ± 28.8 and -5.9* ± 30.1 (*p < 0.001 for the difference from 0). Lin's concordance correlation coefficient showed substantial (0.976), poor (0.737) and poor (0.872) agreement, respectively. The proportion of the index results within the 30% and 10% of GFREDTA measurements were 95% and 74% for GFRDTPA, 53% and 19% for GFRGates, and 83% and 26% for GFRSCr, respectively.

CONCLUSION

In T2DM patients, a clinically acceptable agreement is demonstrated between 51Cr-EDTA and 99mTc-DTPA plasma clearance for GFR measurements, suggesting conditional interchangeability between those compounds. Both the CKD-EPI prediction equation and the Gates' renographic method cannot assess GFR reliably, the latter appearing less unfailing than the former.

Authors+Show Affiliations

Department of Nuclear Medicine, Papageorgiou Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Ring Road, Nea Efkarpia, 56429 Thessaloniki, Greece. Electronic address: emoral@auth.gr.Laboratory of Medical Physics, AHEPA University Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 1 Stilponos Kyriakidi Str, 54636 Thessaloniki, Greece. Electronic address: empapana@auth.gr.1st Propedeutic Department of Internal Medicine, AHEPA University Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 1 Stilponos Kyriakidi Str, 54636 Thessaloniki, Greece. Electronic address: didang@auth.gr.Department of Nuclear Medicine, AHEPA University Hospital, Thessaloniki, 1 Stilponos Kyriakidi Str, 54636 Thessaloniki, Greece.Laboratory of Medical Physics, AHEPA University Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 1 Stilponos Kyriakidi Str, 54636 Thessaloniki, Greece. Electronic address: asiounta@auth.gr.Department of Nuclear Medicine, Papageorgiou Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Ring Road, Nea Efkarpia, 56429 Thessaloniki, Greece. Electronic address: garsos@auth.gr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32057963

Citation

Moralidis, Efstratios, et al. "Determination of the Glomerular Filtration Rate in Patients With Type 2 Diabetes: an Assessment of the Agreement Between 51Cr-EDTA Plasma Clearance and 99mTc-DTPA Plasma Clearance, 99mTc-DTPA Renography and Plasma Creatinine Prediction Equation." Diabetes Research and Clinical Practice, vol. 161, 2020, p. 108079.
Moralidis E, Papanastasiou E, Didangelos T, et al. Determination of the glomerular filtration rate in patients with type 2 diabetes: An assessment of the agreement between 51Cr-EDTA plasma clearance and 99mTc-DTPA plasma clearance, 99mTc-DTPA renography and plasma creatinine prediction equation. Diabetes Res Clin Pract. 2020;161:108079.
Moralidis, E., Papanastasiou, E., Didangelos, T., Hilidis, I., Siountas, A., & Arsos, G. (2020). Determination of the glomerular filtration rate in patients with type 2 diabetes: An assessment of the agreement between 51Cr-EDTA plasma clearance and 99mTc-DTPA plasma clearance, 99mTc-DTPA renography and plasma creatinine prediction equation. Diabetes Research and Clinical Practice, 161, 108079. https://doi.org/10.1016/j.diabres.2020.108079
Moralidis E, et al. Determination of the Glomerular Filtration Rate in Patients With Type 2 Diabetes: an Assessment of the Agreement Between 51Cr-EDTA Plasma Clearance and 99mTc-DTPA Plasma Clearance, 99mTc-DTPA Renography and Plasma Creatinine Prediction Equation. Diabetes Res Clin Pract. 2020;161:108079. PubMed PMID: 32057963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of the glomerular filtration rate in patients with type 2 diabetes: An assessment of the agreement between 51Cr-EDTA plasma clearance and 99mTc-DTPA plasma clearance, 99mTc-DTPA renography and plasma creatinine prediction equation. AU - Moralidis,Efstratios, AU - Papanastasiou,Emmanouil, AU - Didangelos,Triantafyllos, AU - Hilidis,Ilias, AU - Siountas,Anastasios, AU - Arsos,Georgios, Y1 - 2020/02/11/ PY - 2019/11/18/received PY - 2020/02/04/revised PY - 2020/02/10/accepted PY - 2020/2/15/pubmed PY - 2020/6/27/medline PY - 2020/2/15/entrez KW - (51)Cr-EDTA KW - (99m)Tc-DTPA KW - CKD-EPI KW - Diabetic nephropathy KW - Gates’ method KW - Glomerular filtration rate SP - 108079 EP - 108079 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 161 N2 - AIMS: To investigate the agreement of glomerular filtration rate (GFR) determination between 51Cr-ethylenediaminetetraacetic acid (51Cr-EDTA) plasma clearance (GFREDTA) and 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) plasma clearance (GFRDTPA), the Gates 99mTc-DTPA renographic method (GFRGates) and the serum creatinine Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI, GFRSCr) in patients with type 2 diabetes mellitus (T2DM). METHODS: Ninety-nine T2DM patients underwent GFR determinations simultaneously with 51Cr-EDTA and 99mTc-DTPA (using the slope-intercept technique and the Brochner-Mortensen correction) and also with GFRGates and GFRSCr. RESULTS: In the comparison between GFREDTA versus GFRDTPA, GFRGates and GFRSCr, the Bland-Altman statistic provided 0.0 ± 13.2, 17.4* ± 28.8 and -5.9* ± 30.1 (*p < 0.001 for the difference from 0). Lin's concordance correlation coefficient showed substantial (0.976), poor (0.737) and poor (0.872) agreement, respectively. The proportion of the index results within the 30% and 10% of GFREDTA measurements were 95% and 74% for GFRDTPA, 53% and 19% for GFRGates, and 83% and 26% for GFRSCr, respectively. CONCLUSION: In T2DM patients, a clinically acceptable agreement is demonstrated between 51Cr-EDTA and 99mTc-DTPA plasma clearance for GFR measurements, suggesting conditional interchangeability between those compounds. Both the CKD-EPI prediction equation and the Gates' renographic method cannot assess GFR reliably, the latter appearing less unfailing than the former. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/32057963/Determination_of_the_glomerular_filtration_rate_in_patients_with_type_2_diabetes:_An_assessment_of_the_agreement_between_51Cr_EDTA_plasma_clearance_and_99mTc_DTPA_plasma_clearance_99mTc_DTPA_renography_and_plasma_creatinine_prediction_equation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(19)31658-4 DB - PRIME DP - Unbound Medicine ER -