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Higher Intake of Polyunsaturated Fatty Acid and Monounsaturated Fatty Acid is Inversely Associated With AMD.
Invest Ophthalmol Vis Sci. 2020 02 07; 61(2):20.IO

Abstract

Purpose

To evaluate the association between dietary fat intake and the presence of AMD.

Methods

Cross-sectional, observational study with cohorts prospectively recruited from the United States and Portugal. AMD was diagnosed based on color fundus photographs with the AREDS classification. A validated food frequency questionnaire was used to calculate the percent energy intake of trans fat, saturated fat, monounsaturated fatty acid (MUFA), and polyunsaturated fatty acid (PUFA). Odds ratio (OR) and 95% confidence intervals for quintile of amount of FA were calculated. Multiple logistic regression was used to estimate the OR.

Results

We included 483 participants, 386 patients with AMD and 97 controls. Higher intake of trans fat was associated with a 2.3-fold higher odds of presence of AMD (P for trend = 0.0156), whereas a higher intake of PUFA (OR, 0.25; P for trend = 0.006) and MUFA (OR, 0.24; P for trend < 0.0001) presented an inverse association. Subgroup analysis showed that higher quintile of trans fat was associated with increased odds of having intermediate AMD (OR, 2.26; P for trend = 0.02); and higher quintile of PUFA and MUFA were inversely associated with intermediate AMD (OR, 0.2 [P for trend = 0.0013]; OR, 0.17 [P for trend < 0.0001]) and advanced AMD (OR, 0.13 [P for trend = 0.02]; OR, 0.26 [P for trend = 0.004]). Additionally, a statistically significant effect modification by country was noted with inverse association between MUFA and AMD being significant (OR, 0.04; P for trend < 0.0001) for the Portugal population only.

Conclusions

Our study shows that higher dietary intake of trans fat is associated with the presence of AMD, and a higher intake of PUFA and MUFA is inversely associated with AMD.

Pub Type(s)

Journal Article
Multicenter Study
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32058563

Citation

Roh, Miin, et al. "Higher Intake of Polyunsaturated Fatty Acid and Monounsaturated Fatty Acid Is Inversely Associated With AMD." Investigative Ophthalmology & Visual Science, vol. 61, no. 2, 2020, p. 20.
Roh M, Shin HJ, Laíns I, et al. Higher Intake of Polyunsaturated Fatty Acid and Monounsaturated Fatty Acid is Inversely Associated With AMD. Invest Ophthalmol Vis Sci. 2020;61(2):20.
Roh, M., Shin, H. J., Laíns, I., Providência, J., Caseiro-Alves, M., Barreto, P., Vavvas, D. G., Miller, J. B., Kim, I. K., Gaziano, J. M., Liang, L., Silva, R., Miller, J. W., & Husain, D. (2020). Higher Intake of Polyunsaturated Fatty Acid and Monounsaturated Fatty Acid is Inversely Associated With AMD. Investigative Ophthalmology & Visual Science, 61(2), 20. https://doi.org/10.1167/iovs.61.2.20
Roh M, et al. Higher Intake of Polyunsaturated Fatty Acid and Monounsaturated Fatty Acid Is Inversely Associated With AMD. Invest Ophthalmol Vis Sci. 2020 02 7;61(2):20. PubMed PMID: 32058563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher Intake of Polyunsaturated Fatty Acid and Monounsaturated Fatty Acid is Inversely Associated With AMD. AU - Roh,Miin, AU - Shin,Hyun Joon, AU - Laíns,Inês, AU - Providência,Joana, AU - Caseiro-Alves,Maria, AU - Barreto,Patrícia, AU - Vavvas,Demetrios G, AU - Miller,John B, AU - Kim,Ivana K, AU - Gaziano,John Michael, AU - Liang,Liming, AU - Silva,Rufino, AU - Miller,Joan W, AU - Husain,Deeba, PY - 2020/2/15/entrez PY - 2020/2/15/pubmed PY - 2020/4/14/medline SP - 20 EP - 20 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 61 IS - 2 N2 - Purpose: To evaluate the association between dietary fat intake and the presence of AMD. Methods: Cross-sectional, observational study with cohorts prospectively recruited from the United States and Portugal. AMD was diagnosed based on color fundus photographs with the AREDS classification. A validated food frequency questionnaire was used to calculate the percent energy intake of trans fat, saturated fat, monounsaturated fatty acid (MUFA), and polyunsaturated fatty acid (PUFA). Odds ratio (OR) and 95% confidence intervals for quintile of amount of FA were calculated. Multiple logistic regression was used to estimate the OR. Results: We included 483 participants, 386 patients with AMD and 97 controls. Higher intake of trans fat was associated with a 2.3-fold higher odds of presence of AMD (P for trend = 0.0156), whereas a higher intake of PUFA (OR, 0.25; P for trend = 0.006) and MUFA (OR, 0.24; P for trend < 0.0001) presented an inverse association. Subgroup analysis showed that higher quintile of trans fat was associated with increased odds of having intermediate AMD (OR, 2.26; P for trend = 0.02); and higher quintile of PUFA and MUFA were inversely associated with intermediate AMD (OR, 0.2 [P for trend = 0.0013]; OR, 0.17 [P for trend < 0.0001]) and advanced AMD (OR, 0.13 [P for trend = 0.02]; OR, 0.26 [P for trend = 0.004]). Additionally, a statistically significant effect modification by country was noted with inverse association between MUFA and AMD being significant (OR, 0.04; P for trend < 0.0001) for the Portugal population only. Conclusions: Our study shows that higher dietary intake of trans fat is associated with the presence of AMD, and a higher intake of PUFA and MUFA is inversely associated with AMD. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/32058563/Higher_Intake_of_Polyunsaturated_Fatty_Acid_and_Monounsaturated_Fatty_Acid_is_Inversely_Associated_With_AMD_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.61.2.20 DB - PRIME DP - Unbound Medicine ER -