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Is platelet-rich plasma effective for the treatment of knee osteoarthritis? A systematic review and meta-analysis of level 1 and 2 randomized controlled trials.
Eur J Orthop Surg Traumatol. 2020 Feb 14 [Online ahead of print]EJ

Abstract

INTRODUCTION

The purpose of this study was to perform a systematic review and meta-analysis comparing intra-articular knee injection of PRP and hyaluronic acid and investigate clinical outcomes and pain at both 6 and 12 months.

METHODS

A systematic review of Medline, Embase, Scopus, and Google Scholar was performed in the English and German literature reporting on intra-articular knee injections for knee osteoarthritis. All level 1 and 2 studies with a minimum of 6-month follow-up in patients with knee osteoarthritis from 2010 to 2019 were included. Clinical outcome was assessed by WOMAC and IKDC scores and pain by VAS and WOMAC pain scores. Subgroup analysis for autologous platelet-rich plasma (ACP) was performed. Publication bias and risk of bias were assessed using the Cochrane Collaboration's tools. The GRADE system was used to assess the quality of the body of evidence. Heterogeneity was assessed using χ2 and I2 statistics.

RESULTS

Twelve studies (1,248 cases; 636 PRP, 612 HA) met the eligibility criteria. The pooled estimate demonstrated non-significant differences between PRP and HA for clinical outcomes at 6 months (p = 0.069) and at 12 months (p = 0.188). However, the pooled estimate for pain did demonstrate significant differences in favour of PRP at 6 months (p = 0.001) and 12 months (p = 0.001). For the ACP subgroup (249 cases), the pooled estimate for these studies demonstrated significant differences in favour of PRP (p < 0.0001) at 6 months.

CONCLUSION

The results of this systematic review and meta-analysis suggest that PRP is superior to HA for symptomatic knee pain at 6 and 12 months. ACP appears to be clearly superior over HA for pain at both 6 and 12 months. There were no advantages of PRP over HA for clinical outcomes at both 6 and 12 months.

LEVEL OF EVIDENCE

Level 2; systematic review and meta-analysis.

Authors+Show Affiliations

Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. ehohmann@houstonmethodist.org. Department of Orthopaedic Surgery and Sports Medicine, Valiant Clinic/Houston Methodist Group, Dubai, United Arab Emirates. ehohmann@houstonmethodist.org.Department of Orthopaedic Surgery, Royal Brisbane Hospital, Herston, Australia. Department of Surgery, School of Medicine, University of Queensland, Brisbane, Australia. Queensland University of Technology, Brisbane, Australia. Orthopaedic Research Centre of Australia, Brisbane, Australia.Orthopaedic Research Centre of Australia, Brisbane, Australia. University of Texas Health Science Center, San Antonio, TX, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32060630

Citation

Hohmann, Erik, et al. "Is Platelet-rich Plasma Effective for the Treatment of Knee Osteoarthritis? a Systematic Review and Meta-analysis of Level 1 and 2 Randomized Controlled Trials." European Journal of Orthopaedic Surgery & Traumatology : Orthopedie Traumatologie, 2020.
Hohmann E, Tetsworth K, Glatt V. Is platelet-rich plasma effective for the treatment of knee osteoarthritis? A systematic review and meta-analysis of level 1 and 2 randomized controlled trials. Eur J Orthop Surg Traumatol. 2020.
Hohmann, E., Tetsworth, K., & Glatt, V. (2020). Is platelet-rich plasma effective for the treatment of knee osteoarthritis? A systematic review and meta-analysis of level 1 and 2 randomized controlled trials. European Journal of Orthopaedic Surgery & Traumatology : Orthopedie Traumatologie. https://doi.org/10.1007/s00590-020-02623-4
Hohmann E, Tetsworth K, Glatt V. Is Platelet-rich Plasma Effective for the Treatment of Knee Osteoarthritis? a Systematic Review and Meta-analysis of Level 1 and 2 Randomized Controlled Trials. Eur J Orthop Surg Traumatol. 2020 Feb 14; PubMed PMID: 32060630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is platelet-rich plasma effective for the treatment of knee osteoarthritis? A systematic review and meta-analysis of level 1 and 2 randomized controlled trials. AU - Hohmann,Erik, AU - Tetsworth,Kevin, AU - Glatt,Vaida, Y1 - 2020/02/14/ PY - 2019/10/02/received PY - 2020/01/08/accepted PY - 2020/2/16/entrez PY - 2020/2/16/pubmed PY - 2020/2/16/medline KW - Autologous conditioned plasma (ACP) KW - Hyaluronic acid KW - Knee osteoarthritis KW - Knee pain KW - Meta-analysis KW - PRP KW - Platelet-rich plasma KW - Systematic review JF - European journal of orthopaedic surgery & traumatology : orthopedie traumatologie JO - Eur J Orthop Surg Traumatol N2 - INTRODUCTION: The purpose of this study was to perform a systematic review and meta-analysis comparing intra-articular knee injection of PRP and hyaluronic acid and investigate clinical outcomes and pain at both 6 and 12 months. METHODS: A systematic review of Medline, Embase, Scopus, and Google Scholar was performed in the English and German literature reporting on intra-articular knee injections for knee osteoarthritis. All level 1 and 2 studies with a minimum of 6-month follow-up in patients with knee osteoarthritis from 2010 to 2019 were included. Clinical outcome was assessed by WOMAC and IKDC scores and pain by VAS and WOMAC pain scores. Subgroup analysis for autologous platelet-rich plasma (ACP) was performed. Publication bias and risk of bias were assessed using the Cochrane Collaboration's tools. The GRADE system was used to assess the quality of the body of evidence. Heterogeneity was assessed using χ2 and I2 statistics. RESULTS: Twelve studies (1,248 cases; 636 PRP, 612 HA) met the eligibility criteria. The pooled estimate demonstrated non-significant differences between PRP and HA for clinical outcomes at 6 months (p = 0.069) and at 12 months (p = 0.188). However, the pooled estimate for pain did demonstrate significant differences in favour of PRP at 6 months (p = 0.001) and 12 months (p = 0.001). For the ACP subgroup (249 cases), the pooled estimate for these studies demonstrated significant differences in favour of PRP (p < 0.0001) at 6 months. CONCLUSION: The results of this systematic review and meta-analysis suggest that PRP is superior to HA for symptomatic knee pain at 6 and 12 months. ACP appears to be clearly superior over HA for pain at both 6 and 12 months. There were no advantages of PRP over HA for clinical outcomes at both 6 and 12 months. LEVEL OF EVIDENCE: Level 2; systematic review and meta-analysis. SN - 1633-8065 UR - https://www.unboundmedicine.com/medline/citation/32060630/Is_platelet-rich_plasma_effective_for_the_treatment_of_knee_osteoarthritis_A_systematic_review_and_meta-analysis_of_level_1_and_2_randomized_controlled_trials L2 - https://dx.doi.org/10.1007/s00590-020-02623-4 DB - PRIME DP - Unbound Medicine ER -
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