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Is cannabidiol a scheduled controlled substance? Origin makes the difference.
Drug Discov Today. 2020 04; 25(4):628-632.DD

Abstract

Cannabidiol (CBD) is the main cannabinoid naturally occurring in hemp. It has recently attracted the attention of the scientific community because of its numerous pharmacological activities. However, its legal status changes depending on whether it is chemically synthesized or extracted from the plant: extracted CBD is a scheduled controlled substance, whereas synthetic CBD is not under control. In Europe, extracted CBD is excluded from the cosmetic ingredients of the CosIng database. Given the confusion surrounding these different forms of CBD, there is an urgent need for clarity to shed light from both a regulatory and a chemical point of view. The impurity profiles of synthetic and natural CBD are different and could currently represent the only means to distinguish the origin of this substance.

Authors+Show Affiliations

Mediteknology, Spin-off of the National Council of Research, Via Arnesano, 73100 Lecce, Italy; CNR NANOTEC, Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy.Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy.CNR NANOTEC, Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy. Electronic address: giuseppe.cannazza@unimore.it.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32062008

Citation

Citti, Cinzia, et al. "Is Cannabidiol a Scheduled Controlled Substance? Origin Makes the Difference." Drug Discovery Today, vol. 25, no. 4, 2020, pp. 628-632.
Citti C, Linciano P, Cannazza G. Is cannabidiol a scheduled controlled substance? Origin makes the difference. Drug Discov Today. 2020;25(4):628-632.
Citti, C., Linciano, P., & Cannazza, G. (2020). Is cannabidiol a scheduled controlled substance? Origin makes the difference. Drug Discovery Today, 25(4), 628-632. https://doi.org/10.1016/j.drudis.2020.02.001
Citti C, Linciano P, Cannazza G. Is Cannabidiol a Scheduled Controlled Substance? Origin Makes the Difference. Drug Discov Today. 2020;25(4):628-632. PubMed PMID: 32062008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is cannabidiol a scheduled controlled substance? Origin makes the difference. AU - Citti,Cinzia, AU - Linciano,Pasquale, AU - Cannazza,Giuseppe, Y1 - 2020/02/13/ PY - 2019/11/25/received PY - 2020/01/21/revised PY - 2020/02/07/accepted PY - 2020/2/18/pubmed PY - 2021/7/29/medline PY - 2020/2/17/entrez SP - 628 EP - 632 JF - Drug discovery today JO - Drug Discov Today VL - 25 IS - 4 N2 - Cannabidiol (CBD) is the main cannabinoid naturally occurring in hemp. It has recently attracted the attention of the scientific community because of its numerous pharmacological activities. However, its legal status changes depending on whether it is chemically synthesized or extracted from the plant: extracted CBD is a scheduled controlled substance, whereas synthetic CBD is not under control. In Europe, extracted CBD is excluded from the cosmetic ingredients of the CosIng database. Given the confusion surrounding these different forms of CBD, there is an urgent need for clarity to shed light from both a regulatory and a chemical point of view. The impurity profiles of synthetic and natural CBD are different and could currently represent the only means to distinguish the origin of this substance. SN - 1878-5832 UR - https://www.unboundmedicine.com/medline/citation/32062008/Is_cannabidiol_a_scheduled_controlled_substance_Origin_makes_the_difference_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1359-6446(20)30069-6 DB - PRIME DP - Unbound Medicine ER -
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