Tags

Type your tag names separated by a space and hit enter

Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.
Emerg Microbes Infect. 2020; 9(1):386-389.EM

Abstract

In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.

Authors+Show Affiliations

CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.Wuhan Pulmonary Hospital, Wuhan, People's Republic of China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32065057

Citation

Zhang, Wei, et al. "Molecular and Serological Investigation of 2019-nCoV Infected Patients: Implication of Multiple Shedding Routes." Emerging Microbes & Infections, vol. 9, no. 1, 2020, pp. 386-389.
Zhang W, Du RH, Li B, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect. 2020;9(1):386-389.
Zhang, W., Du, R. H., Li, B., Zheng, X. S., Yang, X. L., Hu, B., Wang, Y. Y., Xiao, G. F., Yan, B., Shi, Z. L., & Zhou, P. (2020). Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerging Microbes & Infections, 9(1), 386-389. https://doi.org/10.1080/22221751.2020.1729071
Zhang W, et al. Molecular and Serological Investigation of 2019-nCoV Infected Patients: Implication of Multiple Shedding Routes. Emerg Microbes Infect. 2020;9(1):386-389. PubMed PMID: 32065057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. AU - Zhang,Wei, AU - Du,Rong-Hui, AU - Li,Bei, AU - Zheng,Xiao-Shuang, AU - Yang,Xing-Lou, AU - Hu,Ben, AU - Wang,Yan-Yi, AU - Xiao,Geng-Fu, AU - Yan,Bing, AU - Shi,Zheng-Li, AU - Zhou,Peng, Y1 - 2020/02/17/ PY - 2020/2/18/entrez PY - 2020/2/18/pubmed PY - 2020/3/17/medline KW - 2019-nCoV KW - Wuhan pneumonia KW - epidemiology KW - intestine KW - swabs SP - 386 EP - 389 JF - Emerging microbes & infections JO - Emerg Microbes Infect VL - 9 IS - 1 N2 - In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes. SN - 2222-1751 UR - https://www.unboundmedicine.com/medline/citation/32065057/full_citation L2 - https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1729071 DB - PRIME DP - Unbound Medicine ER -