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Extracellular tRNAs and tRNA-derived fragments.
RNA Biol. 2020 08; 17(8):1149-1167.RB

Abstract

Fragmentation of tRNAs generates a family of small RNAs collectively known as tRNA-derived fragments. These fragments vary in sequence and size but have been shown to regulate many processes involved in cell homoeostasis and adaptations to stress. Additionally, the field of extracellular RNAs (exRNAs) is rapidly growing because exRNAs are a promising source of biomarkers in liquid biopsies, and because exRNAs seem to play key roles in intercellular and interspecies communication. Herein, we review recent descriptions of tRNA-derived fragments in the extracellular space in all domains of life, both in biofluids and in cell culture. The purpose of this review is to find consensus on which tRNA-derived fragments are more prominent in each extracellular fraction (including extracellular vesicles, lipoproteins and ribonucleoprotein complexes). We highlight what is becoming clear and what is still controversial in this field, in order to stimulate future hypothesis-driven studies which could clarify the role of full-length tRNAs and tRNA-derived fragments in the extracellular space.

Authors+Show Affiliations

Analytical Biochemistry Unit, Nuclear Research Center, Faculty of Science, Universidad de la República , Montevideo, Uruguay. Functional Genomics Laboratory, Institut Pasteur de Montevideo , Montevideo, Uruguay.Functional Genomics Laboratory, Institut Pasteur de Montevideo , Montevideo, Uruguay. Department of Medicine, University Hospital, Universidad de la República , Montevideo, Uruguay.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32070197

Citation

Tosar, Juan Pablo, and Alfonso Cayota. "Extracellular tRNAs and tRNA-derived Fragments." RNA Biology, vol. 17, no. 8, 2020, pp. 1149-1167.
Tosar JP, Cayota A. Extracellular tRNAs and tRNA-derived fragments. RNA Biol. 2020;17(8):1149-1167.
Tosar, J. P., & Cayota, A. (2020). Extracellular tRNAs and tRNA-derived fragments. RNA Biology, 17(8), 1149-1167. https://doi.org/10.1080/15476286.2020.1729584
Tosar JP, Cayota A. Extracellular tRNAs and tRNA-derived Fragments. RNA Biol. 2020;17(8):1149-1167. PubMed PMID: 32070197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extracellular tRNAs and tRNA-derived fragments. AU - Tosar,Juan Pablo, AU - Cayota,Alfonso, Y1 - 2020/02/19/ PY - 2020/2/20/pubmed PY - 2020/2/20/medline PY - 2020/2/20/entrez KW - Exosomes KW - intercellular communication KW - tRFs KW - tRNA halves SP - 1149 EP - 1167 JF - RNA biology JO - RNA Biol VL - 17 IS - 8 N2 - Fragmentation of tRNAs generates a family of small RNAs collectively known as tRNA-derived fragments. These fragments vary in sequence and size but have been shown to regulate many processes involved in cell homoeostasis and adaptations to stress. Additionally, the field of extracellular RNAs (exRNAs) is rapidly growing because exRNAs are a promising source of biomarkers in liquid biopsies, and because exRNAs seem to play key roles in intercellular and interspecies communication. Herein, we review recent descriptions of tRNA-derived fragments in the extracellular space in all domains of life, both in biofluids and in cell culture. The purpose of this review is to find consensus on which tRNA-derived fragments are more prominent in each extracellular fraction (including extracellular vesicles, lipoproteins and ribonucleoprotein complexes). We highlight what is becoming clear and what is still controversial in this field, in order to stimulate future hypothesis-driven studies which could clarify the role of full-length tRNAs and tRNA-derived fragments in the extracellular space. SN - 1555-8584 UR - https://www.unboundmedicine.com/medline/citation/32070197/Extracellular_tRNAs_and_tRNA_derived_fragments_ L2 - http://www.tandfonline.com/doi/full/10.1080/15476286.2020.1729584 DB - PRIME DP - Unbound Medicine ER -
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