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Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.
J Thromb Haemost. 2020 04; 18(4):844-847.JT

Abstract

BACKGROUND

In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.

OBJECTIVES

To describe the coagulation feature of patients with NCP.

METHODS

Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed.

RESULTS

The overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay.

CONCLUSIONS

The present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with NCP.

Authors+Show Affiliations

Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32073213

Citation

Tang, Ning, et al. "Abnormal Coagulation Parameters Are Associated With Poor Prognosis in Patients With Novel Coronavirus Pneumonia." Journal of Thrombosis and Haemostasis : JTH, vol. 18, no. 4, 2020, pp. 844-847.
Tang N, Li D, Wang X, et al. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844-847.
Tang, N., Li, D., Wang, X., & Sun, Z. (2020). Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Journal of Thrombosis and Haemostasis : JTH, 18(4), 844-847. https://doi.org/10.1111/jth.14768
Tang N, et al. Abnormal Coagulation Parameters Are Associated With Poor Prognosis in Patients With Novel Coronavirus Pneumonia. J Thromb Haemost. 2020;18(4):844-847. PubMed PMID: 32073213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. AU - Tang,Ning, AU - Li,Dengju, AU - Wang,Xiong, AU - Sun,Ziyong, Y1 - 2020/03/13/ PY - 2020/02/13/received PY - 2020/02/18/accepted PY - 2020/2/20/pubmed PY - 2020/4/9/medline PY - 2020/2/20/entrez KW - D-dimer KW - coagulation parameter KW - disseminated intravascular coagulation KW - fibrin degradation product KW - novel coronavirus pneumonia SP - 844 EP - 847 JF - Journal of thrombosis and haemostasis : JTH JO - J Thromb Haemost VL - 18 IS - 4 N2 - BACKGROUND: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern. OBJECTIVES: To describe the coagulation feature of patients with NCP. METHODS: Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed. RESULTS: The overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay. CONCLUSIONS: The present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with NCP. SN - 1538-7836 UR - https://www.unboundmedicine.com/medline/citation/32073213/full_citation L2 - https://doi.org/10.1111/jth.14768 DB - PRIME DP - Unbound Medicine ER -