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Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China.
Allergy. 2020 07; 75(7):1730-1741.A

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS-CoV-2.

METHODS

Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and analyzed.

RESULTS

An approximately 1:1 ratio of male (50.7%) and female COVID-19 patients was found, with an overall median age of 57.0 years. All patients were community-acquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self-reported by several patients. Asthma or other allergic diseases were not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) patients and current smokers (1.4%) were rare. Bilateral ground-glass or patchy opacity (89.6%) was the most common sign of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (r = .486, P < .001) and nonsevere (r = .469, P < .001) patients after hospital admission. Significantly higher levels of D-dimer, C-reactive protein, and procalcitonin were associated with severe patients compared to nonsevere patients (all P < .001).

CONCLUSION

Detailed clinical investigation of 140 hospitalized COVID-19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. Allergic diseases, asthma, and COPD are not risk factors for SARS-CoV-2 infection. Older age, high number of comorbidities, and more prominent laboratory abnormalities were associated with severe patients.

Authors+Show Affiliations

Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.Department of Respiratory and Critical Care Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, China.Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.Department of Infectious Disease, No. 7 Hospital of Wuhan, Wuhan, China.Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32077115

Citation

Zhang, Jin-Jin, et al. "Clinical Characteristics of 140 Patients Infected With SARS-CoV-2 in Wuhan, China." Allergy, vol. 75, no. 7, 2020, pp. 1730-1741.
Zhang JJ, Dong X, Cao YY, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020;75(7):1730-1741.
Zhang, J. J., Dong, X., Cao, Y. Y., Yuan, Y. D., Yang, Y. B., Yan, Y. Q., Akdis, C. A., & Gao, Y. D. (2020). Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy, 75(7), 1730-1741. https://doi.org/10.1111/all.14238
Zhang JJ, et al. Clinical Characteristics of 140 Patients Infected With SARS-CoV-2 in Wuhan, China. Allergy. 2020;75(7):1730-1741. PubMed PMID: 32077115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. AU - Zhang,Jin-Jin, AU - Dong,Xiang, AU - Cao,Yi-Yuan, AU - Yuan,Ya-Dong, AU - Yang,Yi-Bin, AU - Yan,You-Qin, AU - Akdis,Cezmi A, AU - Gao,Ya-Dong, Y1 - 2020/02/27/ PY - 2020/02/17/received PY - 2020/02/18/revised PY - 2020/02/18/accepted PY - 2020/2/23/pubmed PY - 2020/8/4/medline PY - 2020/2/21/entrez KW - COVID-19 KW - SARS-CoV-2 KW - allergy KW - eosinophil KW - risk factor SP - 1730 EP - 1741 JF - Allergy JO - Allergy VL - 75 IS - 7 N2 - BACKGROUND: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS-CoV-2. METHODS: Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and analyzed. RESULTS: An approximately 1:1 ratio of male (50.7%) and female COVID-19 patients was found, with an overall median age of 57.0 years. All patients were community-acquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self-reported by several patients. Asthma or other allergic diseases were not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) patients and current smokers (1.4%) were rare. Bilateral ground-glass or patchy opacity (89.6%) was the most common sign of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (r = .486, P < .001) and nonsevere (r = .469, P < .001) patients after hospital admission. Significantly higher levels of D-dimer, C-reactive protein, and procalcitonin were associated with severe patients compared to nonsevere patients (all P < .001). CONCLUSION: Detailed clinical investigation of 140 hospitalized COVID-19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. Allergic diseases, asthma, and COPD are not risk factors for SARS-CoV-2 infection. Older age, high number of comorbidities, and more prominent laboratory abnormalities were associated with severe patients. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/32077115/Clinical_characteristics_of_140_patients_infected_with_SARS_CoV_2_in_Wuhan_China_ L2 - https://doi.org/10.1111/all.14238 DB - PRIME DP - Unbound Medicine ER -