Tags

Type your tag names separated by a space and hit enter

Extracellular ubiquitin levels are increased in coronary heart disease and associated with the severity of the disease.
Scand J Clin Lab Invest. 2020 May; 80(3):256-264.SJ

Abstract

Aim:

This study aimed to evaluate concentration of plasma extracellular ubiquitin (UB) in coronary heart disease (CHD) patients and its correlation with the disease severity.

Methods:

Levels of UB and stromal cell-derived factor-1a (SDF-1a) were measured in 60 healthy controls and 67 CHD cases. Coronary atherosclerosis was assessed with Gensini scoring system. Spearman correlation was used to evaluate the correlation between UB and low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), creatine kinase-MB (CK-MB), cardiac troponin I (cTnI) or SDF-1a. The receiver-operating characteristic (ROC) curve was established to assess the predictive value of UB.

Results:

Plasma UB levels were significantly higher in CHD patients than in controls (p < .0001), and the levels in those with acute myocardial infarction (AMI) were higher than stable angina pectoris (SAP) and unstable angina pectoris (UAP) groups (both p < .01). UB was also positively correlated with Gensini score, CRP, CK-MB and cTnI in CHD. ROC analysis of UB showed that the area under the curve (AUC) were 0.711 (95%CI, 0.623-0.799) and 0.778 (95%CI, 0.666-0.890) for CHD and acute coronary syndrome (ACS), respectively. Plasma SDF-1a levels were elevated in CHD patients but showed no significant correlation with UB concentration or the severity of the disease.

Conclusion:

Plasma UB concentration was increased in CHD and the change of UB levels may reflect the progression of CHD.

Authors+Show Affiliations

MOE Engineering Center of Hematological Disease, MOH Key Lab of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China.Department of Cardiology, Suzhou Municipal Hospital, Suzhou, China.MOE Engineering Center of Hematological Disease, MOH Key Lab of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China.MOE Engineering Center of Hematological Disease, MOH Key Lab of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China.Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.MOE Engineering Center of Hematological Disease, MOH Key Lab of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32077763

Citation

Ji, Yiqun, et al. "Extracellular Ubiquitin Levels Are Increased in Coronary Heart Disease and Associated With the Severity of the Disease." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 80, no. 3, 2020, pp. 256-264.
Ji Y, Yao J, Zhao Y, et al. Extracellular ubiquitin levels are increased in coronary heart disease and associated with the severity of the disease. Scand J Clin Lab Invest. 2020;80(3):256-264.
Ji, Y., Yao, J., Zhao, Y., Zhai, J., Weng, Z., & He, Y. (2020). Extracellular ubiquitin levels are increased in coronary heart disease and associated with the severity of the disease. Scandinavian Journal of Clinical and Laboratory Investigation, 80(3), 256-264. https://doi.org/10.1080/00365513.2020.1728783
Ji Y, et al. Extracellular Ubiquitin Levels Are Increased in Coronary Heart Disease and Associated With the Severity of the Disease. Scand J Clin Lab Invest. 2020;80(3):256-264. PubMed PMID: 32077763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extracellular ubiquitin levels are increased in coronary heart disease and associated with the severity of the disease. AU - Ji,Yiqun, AU - Yao,Jialu, AU - Zhao,Yunxiao, AU - Zhai,Juping, AU - Weng,Zhen, AU - He,Yang, Y1 - 2020/02/20/ PY - 2020/2/23/pubmed PY - 2021/7/17/medline PY - 2020/2/21/entrez KW - Ubiquitin KW - acute coronary syndrome KW - atherosclerosis KW - coronary heart disease KW - molecular diagnostics SP - 256 EP - 264 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 80 IS - 3 N2 - Aim: This study aimed to evaluate concentration of plasma extracellular ubiquitin (UB) in coronary heart disease (CHD) patients and its correlation with the disease severity.Methods: Levels of UB and stromal cell-derived factor-1a (SDF-1a) were measured in 60 healthy controls and 67 CHD cases. Coronary atherosclerosis was assessed with Gensini scoring system. Spearman correlation was used to evaluate the correlation between UB and low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), creatine kinase-MB (CK-MB), cardiac troponin I (cTnI) or SDF-1a. The receiver-operating characteristic (ROC) curve was established to assess the predictive value of UB.Results: Plasma UB levels were significantly higher in CHD patients than in controls (p < .0001), and the levels in those with acute myocardial infarction (AMI) were higher than stable angina pectoris (SAP) and unstable angina pectoris (UAP) groups (both p < .01). UB was also positively correlated with Gensini score, CRP, CK-MB and cTnI in CHD. ROC analysis of UB showed that the area under the curve (AUC) were 0.711 (95%CI, 0.623-0.799) and 0.778 (95%CI, 0.666-0.890) for CHD and acute coronary syndrome (ACS), respectively. Plasma SDF-1a levels were elevated in CHD patients but showed no significant correlation with UB concentration or the severity of the disease.Conclusion: Plasma UB concentration was increased in CHD and the change of UB levels may reflect the progression of CHD. SN - 1502-7686 UR - https://www.unboundmedicine.com/medline/citation/32077763/Extracellular_ubiquitin_levels_are_increased_in_coronary_heart_disease_and_associated_with_the_severity_of_the_disease_ L2 - https://www.tandfonline.com/doi/full/10.1080/00365513.2020.1728783 DB - PRIME DP - Unbound Medicine ER -