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Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin.
Mar Drugs. 2020 Feb 17; 18(2)MD

Abstract

Chitin has been investigated in the context of finding new excipients suitable for direct compression, when subjected to roller compaction. Ball milling was concurrently carried out to compare effects from different energy or stress-inducing techniques. Samples of chitin powders (raw, processed, dried and humidified) were compared for variations in morphology, X-ray diffraction patterns, densities, FT-IR, flowability, compressibility and compactibility. Results confirmed the suitability of roller compaction to convert the fluffy powder of raw chitin to a bulky material with improved flow. X-ray powder diffraction studies showed that, in contrast to the high decrease in crystallinity upon ball milling, roller compaction manifested a slight deformation in the crystal lattice. Moreover, the new excipient showed high resistance to compression, due to the high compactibility of the granules formed. This was correlated to the significant extent of plastic deformation compared to the raw and ball milled forms of chitin. On the other hand, drying and humidification of raw and processed materials presented no added value to the compressibility and compactibility of the directly compressed excipient. Finally, compacted chitin showed direct compression similarity with microcrystalline cellulose when formulated with metronidazole (200 mg) without affecting the immediate drug release action of the drug.

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Authors+Show Affiliations

Abu Fara D
Chemical Engineering Department, School of Engineering, University of Jordan, Amman 11942, Jordan.
Al-Hmoud L
Chemical Engineering Department, School of Engineering, University of Jordan, Amman 11942, Jordan.
Rashid I
Research and Innovation Centre, The Jordanian Pharmaceutical Manufacturing Company (JPM), P.O. Box 94, Naor 11710, Jordan.
Chowdhry BZ
School of Science, Faculty of Engineering & Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK.
Badwan A
Research and Innovation Centre, The Jordanian Pharmaceutical Manufacturing Company (JPM), P.O. Box 94, Naor 11710, Jordan.

MeSH

ChitinDrug CompoundingDrug LiberationExcipientsParticle SizePowdersPressureTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32079246

Citation

Abu Fara, Deeb, et al. "Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin." Marine Drugs, vol. 18, no. 2, 2020.
Abu Fara D, Al-Hmoud L, Rashid I, et al. Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin. Mar Drugs. 2020;18(2).
Abu Fara, D., Al-Hmoud, L., Rashid, I., Chowdhry, B. Z., & Badwan, A. (2020). Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin. Marine Drugs, 18(2). https://doi.org/10.3390/md18020115
Abu Fara D, et al. Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin. Mar Drugs. 2020 Feb 17;18(2) PubMed PMID: 32079246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin. AU - Abu Fara,Deeb, AU - Al-Hmoud,Linda, AU - Rashid,Iyad, AU - Chowdhry,Babur Z, AU - Badwan,Adnan, Y1 - 2020/02/17/ PY - 2020/01/07/received PY - 2020/02/04/revised PY - 2020/02/12/accepted PY - 2020/2/22/entrez PY - 2020/2/23/pubmed PY - 2020/12/15/medline KW - Hausner ratio KW - Kawakita analysis KW - ball milling KW - bulk density KW - chitin KW - compression work KW - crushing strength KW - direct compression KW - dissolution KW - roller compaction JF - Marine drugs JO - Mar Drugs VL - 18 IS - 2 N2 - Chitin has been investigated in the context of finding new excipients suitable for direct compression, when subjected to roller compaction. Ball milling was concurrently carried out to compare effects from different energy or stress-inducing techniques. Samples of chitin powders (raw, processed, dried and humidified) were compared for variations in morphology, X-ray diffraction patterns, densities, FT-IR, flowability, compressibility and compactibility. Results confirmed the suitability of roller compaction to convert the fluffy powder of raw chitin to a bulky material with improved flow. X-ray powder diffraction studies showed that, in contrast to the high decrease in crystallinity upon ball milling, roller compaction manifested a slight deformation in the crystal lattice. Moreover, the new excipient showed high resistance to compression, due to the high compactibility of the granules formed. This was correlated to the significant extent of plastic deformation compared to the raw and ball milled forms of chitin. On the other hand, drying and humidification of raw and processed materials presented no added value to the compressibility and compactibility of the directly compressed excipient. Finally, compacted chitin showed direct compression similarity with microcrystalline cellulose when formulated with metronidazole (200 mg) without affecting the immediate drug release action of the drug. SN - 1660-3397 UR - https://www.unboundmedicine.com/medline/citation/32079246/Understanding_the_Performance_of_a_Novel_Direct_Compression_Excipient_Comprising_Roller_Compacted_Chitin_ DB - PRIME DP - Unbound Medicine ER -