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New advances in the characterization of lyophilised orally disintegrating tablets.
Int J Pharm. 2020 Apr 15; 579:119153.IJ

Abstract

Orally disintegrating tablets (ODTs) produced by lyophilisation have a unique porous structure which leads to a favorable orodispersable functionality. They possess ultra-fast disintegration kinetics, have acceptable mechanical strength and give a smooth mouth texture. Only limited literature is available on the characterization of ODTs and even fewer on lyophilised tablets. The suitability of a broad range of characterization methods for lyophilised tablets was evaluated since they possess other mechanical properties compared to compressed tablets. Four ODTs with diverse properties were carefully selected and thoroughly analysed using various characterization techniques leading to a multitude of descriptors. The functionality of these four lyophilised tablets was examined and the relation between the different descriptors was evaluated using a Principal Component Analysis (PCA). Furthermore, μCT images of two ODTs were acquired to study the internal structure and active pharmaceutical ingredient (API) distribution inside the tablets. The important descriptors, disintegration and mechanical strength, interacted inversely indicating the importance of a well-balanced ODT formulation to achieve favorable properties. μCT data can improve the process knowledge as it yields very diverse descriptors. Ultimately, the different tablets were ranked at their performance.

Authors+Show Affiliations

Laboratory of Pharmaceutical Process Analytical Technology (LPPAT), Department of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Brecht.Vanbillemont@UGent.be.Laboratory of Pharmaceutical Process Analytical Technology (LPPAT), Department of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.Laboratory of Pharmaceutical Process Analytical Technology (LPPAT), Department of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Thomas.DeBeer@UGent.be.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32084575

Citation

Vanbillemont, Brecht, et al. "New Advances in the Characterization of Lyophilised Orally Disintegrating Tablets." International Journal of Pharmaceutics, vol. 579, 2020, p. 119153.
Vanbillemont B, Everaert H, De Beer T. New advances in the characterization of lyophilised orally disintegrating tablets. Int J Pharm. 2020;579:119153.
Vanbillemont, B., Everaert, H., & De Beer, T. (2020). New advances in the characterization of lyophilised orally disintegrating tablets. International Journal of Pharmaceutics, 579, 119153. https://doi.org/10.1016/j.ijpharm.2020.119153
Vanbillemont B, Everaert H, De Beer T. New Advances in the Characterization of Lyophilised Orally Disintegrating Tablets. Int J Pharm. 2020 Apr 15;579:119153. PubMed PMID: 32084575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New advances in the characterization of lyophilised orally disintegrating tablets. AU - Vanbillemont,Brecht, AU - Everaert,Hannelien, AU - De Beer,Thomas, Y1 - 2020/02/19/ PY - 2020/01/16/received PY - 2020/02/11/revised PY - 2020/02/15/accepted PY - 2020/2/23/pubmed PY - 2020/2/23/medline PY - 2020/2/22/entrez KW - Disintegration KW - Freeze-drying KW - Mechanical strenght KW - Orodispersible tablets KW - Principal component analysis KW - X-ray micro computed tomography SP - 119153 EP - 119153 JF - International journal of pharmaceutics JO - Int J Pharm VL - 579 N2 - Orally disintegrating tablets (ODTs) produced by lyophilisation have a unique porous structure which leads to a favorable orodispersable functionality. They possess ultra-fast disintegration kinetics, have acceptable mechanical strength and give a smooth mouth texture. Only limited literature is available on the characterization of ODTs and even fewer on lyophilised tablets. The suitability of a broad range of characterization methods for lyophilised tablets was evaluated since they possess other mechanical properties compared to compressed tablets. Four ODTs with diverse properties were carefully selected and thoroughly analysed using various characterization techniques leading to a multitude of descriptors. The functionality of these four lyophilised tablets was examined and the relation between the different descriptors was evaluated using a Principal Component Analysis (PCA). Furthermore, μCT images of two ODTs were acquired to study the internal structure and active pharmaceutical ingredient (API) distribution inside the tablets. The important descriptors, disintegration and mechanical strength, interacted inversely indicating the importance of a well-balanced ODT formulation to achieve favorable properties. μCT data can improve the process knowledge as it yields very diverse descriptors. Ultimately, the different tablets were ranked at their performance. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/32084575/New_advances_in_the_characterization_of_lyophilised_orally_disintegrating_tablets L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(20)30137-X DB - PRIME DP - Unbound Medicine ER -
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