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Pericoronary adipose tissue and quantitative global non-calcified plaque characteristics from CT angiography do not differ in matched South Asian, East Asian and European-origin Caucasian patients with stable chest pain.
Eur J Radiol. 2020 Apr; 125:108874.EJ

Abstract

PURPOSE

South Asian (SA) have been observed to have higher cardiovascular mortality rates compared to East Asians (EA) and Caucasians. Pericoronary adipose tissue (PCAT) attenuation around the right coronary artery (RCA) from coronary CT angiography (CTA) has been associated with coronary inflammation and cardiac death. We aimed to investigate i) the relationship between plaque characteristics and PCAT attenuation and ii) to assess gender and ethnic differences in PCAT attenuation using a matched cohort of SA, EA and Caucasians.

METHOD

Three-hundred symptomatic patients who underwent CTA were matched for age, gender, BMI and diabetes (100 in each ethnic group). Semi-automated software was used to quantify the total volumes and burden of non-calcified plaque (NCP), low-density non-calcified plaque (LD-NCP) and calcified plaque (CP) in blinded core-lab analysis. PCAT CT attenuation was measured around the RCA (10-50 mm from RCA ostium), the most standardized model for PCAT analysis.

RESULTS

The total volumes and burden of NCP, LD-NCP and CP were comparable in the ethnic groups (each p > 0.05). PCAT attenuation was higher in patients with coronary plaque. PCAT attenuation correlated with the total volumes and burden of NCP, LD-NCP and CP (r>0.17; p < 0.003). Within the RCA this correlation persisted only for NCP features (r>0.39;p < 0.001). Males showed higher PCAT attenuation (p < 0.001). PCAT attenuation was similar between Caucasian, EA and SA (p = 0.32).

CONCLUSIONS

PCAT CT attenuation correlated most with its surrounded NCP features further highlighting its role as surrogate measure of coronary inflammation. As coronary plaque burden and RCA PCAT attenuation did not differ between ethnic groups, causes of increased cardiac mortality in South Asians needs further investigations.

Authors+Show Affiliations

Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Faculty of Medicine, Department of Cardiology, Erlangen, Germany; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Markus.Goeller@uk-erlangen.de.Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia. Electronic address: absnet@iinet.net.au.Department of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Sebastien.Cadet@cshs.org.Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia. Electronic address: Andrew.Lin3@cshs.org.Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia. Electronic address: dan_adams_27@hotmail.com.Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia. Electronic address: uditthakur11@gmail.com.Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia. Electronic address: gracenyap@gmail.com.Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Faculty of Medicine, Department of Cardiology, Erlangen, Germany. Electronic address: Mohamed.Marwan@uk-erlangen.de.Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Faculty of Medicine, Department of Cardiology, Erlangen, Germany. Electronic address: Stephan.Achenbach@uk-erlangen.de.Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Damini.Dey@cshs.org.Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia. Electronic address: brianshiuhangko@gmail.com.

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

32087467

Citation

Goeller, Markus, et al. "Pericoronary Adipose Tissue and Quantitative Global Non-calcified Plaque Characteristics From CT Angiography Do Not Differ in Matched South Asian, East Asian and European-origin Caucasian Patients With Stable Chest Pain." European Journal of Radiology, vol. 125, 2020, p. 108874.
Goeller M, Rahman Ihdayhid A, Cadet S, et al. Pericoronary adipose tissue and quantitative global non-calcified plaque characteristics from CT angiography do not differ in matched South Asian, East Asian and European-origin Caucasian patients with stable chest pain. Eur J Radiol. 2020;125:108874.
Goeller, M., Rahman Ihdayhid, A., Cadet, S., Lin, A., Adams, D., Thakur, U., Yap, G., Marwan, M., Achenbach, S., Dey, D., & Ko, B. (2020). Pericoronary adipose tissue and quantitative global non-calcified plaque characteristics from CT angiography do not differ in matched South Asian, East Asian and European-origin Caucasian patients with stable chest pain. European Journal of Radiology, 125, 108874. https://doi.org/10.1016/j.ejrad.2020.108874
Goeller M, et al. Pericoronary Adipose Tissue and Quantitative Global Non-calcified Plaque Characteristics From CT Angiography Do Not Differ in Matched South Asian, East Asian and European-origin Caucasian Patients With Stable Chest Pain. Eur J Radiol. 2020;125:108874. PubMed PMID: 32087467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pericoronary adipose tissue and quantitative global non-calcified plaque characteristics from CT angiography do not differ in matched South Asian, East Asian and European-origin Caucasian patients with stable chest pain. AU - Goeller,Markus, AU - Rahman Ihdayhid,Abdul, AU - Cadet,Sebastien, AU - Lin,Andrew, AU - Adams,Daniel, AU - Thakur,Udit, AU - Yap,Grace, AU - Marwan,Mohamed, AU - Achenbach,Stephan, AU - Dey,Damini, AU - Ko,Brian, Y1 - 2020/02/07/ PY - 2019/12/15/received PY - 2020/01/21/revised PY - 2020/02/05/accepted PY - 2020/2/23/pubmed PY - 2020/11/4/medline PY - 2020/2/23/entrez KW - Atherosclerosis KW - Computerized tomography (CT) KW - Pericoronary adipose tissue KW - Race and ethnicity SP - 108874 EP - 108874 JF - European journal of radiology JO - Eur J Radiol VL - 125 N2 - PURPOSE: South Asian (SA) have been observed to have higher cardiovascular mortality rates compared to East Asians (EA) and Caucasians. Pericoronary adipose tissue (PCAT) attenuation around the right coronary artery (RCA) from coronary CT angiography (CTA) has been associated with coronary inflammation and cardiac death. We aimed to investigate i) the relationship between plaque characteristics and PCAT attenuation and ii) to assess gender and ethnic differences in PCAT attenuation using a matched cohort of SA, EA and Caucasians. METHOD: Three-hundred symptomatic patients who underwent CTA were matched for age, gender, BMI and diabetes (100 in each ethnic group). Semi-automated software was used to quantify the total volumes and burden of non-calcified plaque (NCP), low-density non-calcified plaque (LD-NCP) and calcified plaque (CP) in blinded core-lab analysis. PCAT CT attenuation was measured around the RCA (10-50 mm from RCA ostium), the most standardized model for PCAT analysis. RESULTS: The total volumes and burden of NCP, LD-NCP and CP were comparable in the ethnic groups (each p > 0.05). PCAT attenuation was higher in patients with coronary plaque. PCAT attenuation correlated with the total volumes and burden of NCP, LD-NCP and CP (r>0.17; p < 0.003). Within the RCA this correlation persisted only for NCP features (r>0.39;p < 0.001). Males showed higher PCAT attenuation (p < 0.001). PCAT attenuation was similar between Caucasian, EA and SA (p = 0.32). CONCLUSIONS: PCAT CT attenuation correlated most with its surrounded NCP features further highlighting its role as surrogate measure of coronary inflammation. As coronary plaque burden and RCA PCAT attenuation did not differ between ethnic groups, causes of increased cardiac mortality in South Asians needs further investigations. SN - 1872-7727 UR - https://www.unboundmedicine.com/medline/citation/32087467/Pericoronary_adipose_tissue_and_quantitative_global_non_calcified_plaque_characteristics_from_CT_angiography_do_not_differ_in_matched_South_Asian_East_Asian_and_European_origin_Caucasian_patients_with_stable_chest_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0720-048X(20)30063-2 DB - PRIME DP - Unbound Medicine ER -