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Acne vulgaris and risk of depression and anxiety: A meta-analytic review.
J Am Acad Dermatol. 2020 Aug; 83(2):532-541.JA

Abstract

BACKGROUND

Several studies have shown an association of acne vulgaris with depression and anxiety, but a quantitative review has not yet been conducted.

OBJECTIVE

We sought to conduct a systematic review and meta-analysis that elucidates the association of acne vulgaris with depression and anxiety.

METHODS

A systematic review and meta-analysis of literature published before October 1, 2019 from the PubMed, PsycINFO, MEDLINE, and Cochrane databases was conducted. We used a metaanalytic approach to perform a random effects analysis comparing individuals with and without acne. Subgroup analyses between studies included age, study setting, and geographic region.

RESULTS

Forty-two studies were included. We found a significant association of acne vulgaris with depression (r = 0.22 [95% confidence interval 0.17-0.26, P < .00001]) and anxiety (r = 0.25 [95% confidence interval 0.19-0.31, P < .00001]). Subgroup analyses and comparisons showed moderating influences based on factors including age, study setting, and geographic region.

LIMITATIONS

Inconsistency between publications regarding acne and outcome ascertainment, data reporting, and studies with no control group posed considerable barriers to synthesizing all available published literature.

CONCLUSIONS

Because of an increased risk for depression and anxiety, clinicians should pursue aggressive treatment of acne and consider psychiatric screening or referrals.

Authors+Show Affiliations

Department of Psychological and Brain Sciences, University of Massachusetts, Amherst, Massachusetts. Electronic address: dvsamuels@umass.edu.Department of Psychology, University of California, Riverside, California.University of North Texas Health Science Center, Texas College of Osteopathic Medicine, Fort Worth, Texas; Bay Area Corpus Christi Medical Center, South Texas Dermatology Residency Program, McAllen, Texas.University of North Texas Health Science Center, Texas College of Osteopathic Medicine, Fort Worth, Texas; Bay Area Corpus Christi Medical Center, South Texas Dermatology Residency Program, McAllen, Texas.Department of Psychology, University of California, Riverside, California.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

32088269

Citation

Samuels, Danielle V., et al. "Acne Vulgaris and Risk of Depression and Anxiety: a Meta-analytic Review." Journal of the American Academy of Dermatology, vol. 83, no. 2, 2020, pp. 532-541.
Samuels DV, Rosenthal R, Lin R, et al. Acne vulgaris and risk of depression and anxiety: A meta-analytic review. J Am Acad Dermatol. 2020;83(2):532-541.
Samuels, D. V., Rosenthal, R., Lin, R., Chaudhari, S., & Natsuaki, M. N. (2020). Acne vulgaris and risk of depression and anxiety: A meta-analytic review. Journal of the American Academy of Dermatology, 83(2), 532-541. https://doi.org/10.1016/j.jaad.2020.02.040
Samuels DV, et al. Acne Vulgaris and Risk of Depression and Anxiety: a Meta-analytic Review. J Am Acad Dermatol. 2020;83(2):532-541. PubMed PMID: 32088269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acne vulgaris and risk of depression and anxiety: A meta-analytic review. AU - Samuels,Danielle V, AU - Rosenthal,Robert, AU - Lin,Rick, AU - Chaudhari,Soham, AU - Natsuaki,Misaki N, Y1 - 2020/02/20/ PY - 2019/05/22/received PY - 2020/02/10/revised PY - 2020/02/14/accepted PY - 2020/2/24/pubmed PY - 2021/2/25/medline PY - 2020/2/24/entrez KW - acne KW - acne vulgaris KW - adolescence KW - anxiety KW - depression KW - meta-analysis KW - meta-analytic review KW - psychiatric morbidity SP - 532 EP - 541 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 83 IS - 2 N2 - BACKGROUND: Several studies have shown an association of acne vulgaris with depression and anxiety, but a quantitative review has not yet been conducted. OBJECTIVE: We sought to conduct a systematic review and meta-analysis that elucidates the association of acne vulgaris with depression and anxiety. METHODS: A systematic review and meta-analysis of literature published before October 1, 2019 from the PubMed, PsycINFO, MEDLINE, and Cochrane databases was conducted. We used a metaanalytic approach to perform a random effects analysis comparing individuals with and without acne. Subgroup analyses between studies included age, study setting, and geographic region. RESULTS: Forty-two studies were included. We found a significant association of acne vulgaris with depression (r = 0.22 [95% confidence interval 0.17-0.26, P < .00001]) and anxiety (r = 0.25 [95% confidence interval 0.19-0.31, P < .00001]). Subgroup analyses and comparisons showed moderating influences based on factors including age, study setting, and geographic region. LIMITATIONS: Inconsistency between publications regarding acne and outcome ascertainment, data reporting, and studies with no control group posed considerable barriers to synthesizing all available published literature. CONCLUSIONS: Because of an increased risk for depression and anxiety, clinicians should pursue aggressive treatment of acne and consider psychiatric screening or referrals. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/32088269/Acne_vulgaris_and_risk_of_depression_and_anxiety:_A_meta_analytic_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(20)30279-6 DB - PRIME DP - Unbound Medicine ER -