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3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients.
Pharmaceutics. 2020 Feb 19; 12(2)P

Abstract

Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating printlets (ODPs) suited for patients with visual impairment. Printlets were designed with Braille and Moon patterns on their surface, enabling patients to identify medications when taken out of their original packaging. Printlets with different shapes were fabricated to offer additional information, such as the medication indication or its dosing regimen. Despite the presence of the patterns, the printlets retained their original mechanical properties and dissolution characteristics, wherein all the printlets disintegrated within ~5 s, avoiding the need for water and facilitating self-administration of medications. Moreover, the readability of the printlets was verified by a blind person. Overall, this novel and practical approach should reduce medication errors and improve medication adherence in patients with visual impairment.

Authors+Show Affiliations

Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK. Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I + D Farma Group (GI-1645), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK.Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32092945

Citation

Awad, Atheer, et al. "3D Printed Tablets (Printlets) With Braille and Moon Patterns for Visually Impaired Patients." Pharmaceutics, vol. 12, no. 2, 2020.
Awad A, Yao A, Trenfield SJ, et al. 3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients. Pharmaceutics. 2020;12(2).
Awad, A., Yao, A., Trenfield, S. J., Goyanes, A., Gaisford, S., & Basit, A. W. (2020). 3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients. Pharmaceutics, 12(2). https://doi.org/10.3390/pharmaceutics12020172
Awad A, et al. 3D Printed Tablets (Printlets) With Braille and Moon Patterns for Visually Impaired Patients. Pharmaceutics. 2020 Feb 19;12(2) PubMed PMID: 32092945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients. AU - Awad,Atheer, AU - Yao,Aliya, AU - Trenfield,Sarah J, AU - Goyanes,Alvaro, AU - Gaisford,Simon, AU - Basit,Abdul W, Y1 - 2020/02/19/ PY - 2019/12/21/received PY - 2020/01/27/revised PY - 2020/02/11/accepted PY - 2020/2/26/entrez PY - 2020/2/26/pubmed PY - 2020/2/26/medline KW - 3D printed drug products KW - blindness KW - orally disintegrating tablets KW - personalised medicines KW - personalized pharmaceuticals KW - sight loss KW - tactile patterns KW - three-dimensional printing KW - touch-reading compliance KW - visual deprivation JF - Pharmaceutics JO - Pharmaceutics VL - 12 IS - 2 N2 - Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating printlets (ODPs) suited for patients with visual impairment. Printlets were designed with Braille and Moon patterns on their surface, enabling patients to identify medications when taken out of their original packaging. Printlets with different shapes were fabricated to offer additional information, such as the medication indication or its dosing regimen. Despite the presence of the patterns, the printlets retained their original mechanical properties and dissolution characteristics, wherein all the printlets disintegrated within ~5 s, avoiding the need for water and facilitating self-administration of medications. Moreover, the readability of the printlets was verified by a blind person. Overall, this novel and practical approach should reduce medication errors and improve medication adherence in patients with visual impairment. SN - 1999-4923 UR - https://www.unboundmedicine.com/medline/citation/32092945/3D_Printed_Tablets_(Printlets)_with_Braille_and_Moon_Patterns_for_Visually_Impaired_Patients L2 - http://www.mdpi.com/resolver?pii=pharmaceutics12020172 DB - PRIME DP - Unbound Medicine ER -
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