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The effects of pentoxifylline on cochlear blood flow in normotensive and spontaneously hypertensive rats.
Hear Res. 1988 Nov; 36(2-3):175-80.HR

Abstract

Normotensive and spontaneously hypertensive rats (SHRs) were given arterial infusions of saline and pentoxifylline in doses of 1.5, 2.0, and 3.0 mg/kg/min. Blood pressure decreased in a dose related fashion with increasing doses of pentoxifylline. Cochlear blood flow, measured via laser Doppler flowmeter, increased with infusion of pentoxifylline in members of both rat strains, but to a greater extent in SHRs than in normotensive animals. The mechanism of action appears to be decreased red blood cell rigidity which allows increased penetration of red blood cells into microvessels of the cochlea.

Authors+Show Affiliations

Department of Psychology, Washington State University, Pullman 99164.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3209490

Citation

Quirk, W S., et al. "The Effects of Pentoxifylline On Cochlear Blood Flow in Normotensive and Spontaneously Hypertensive Rats." Hearing Research, vol. 36, no. 2-3, 1988, pp. 175-80.
Quirk WS, Dengerink HA, Bademian MJ, et al. The effects of pentoxifylline on cochlear blood flow in normotensive and spontaneously hypertensive rats. Hear Res. 1988;36(2-3):175-80.
Quirk, W. S., Dengerink, H. A., Bademian, M. J., Hall, K. W., & Wright, J. W. (1988). The effects of pentoxifylline on cochlear blood flow in normotensive and spontaneously hypertensive rats. Hearing Research, 36(2-3), 175-80.
Quirk WS, et al. The Effects of Pentoxifylline On Cochlear Blood Flow in Normotensive and Spontaneously Hypertensive Rats. Hear Res. 1988;36(2-3):175-80. PubMed PMID: 3209490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of pentoxifylline on cochlear blood flow in normotensive and spontaneously hypertensive rats. AU - Quirk,W S, AU - Dengerink,H A, AU - Bademian,M J, AU - Hall,K W, AU - Wright,J W, PY - 1988/11/1/pubmed PY - 1988/11/1/medline PY - 1988/11/1/entrez SP - 175 EP - 80 JF - Hearing research JO - Hear. Res. VL - 36 IS - 2-3 N2 - Normotensive and spontaneously hypertensive rats (SHRs) were given arterial infusions of saline and pentoxifylline in doses of 1.5, 2.0, and 3.0 mg/kg/min. Blood pressure decreased in a dose related fashion with increasing doses of pentoxifylline. Cochlear blood flow, measured via laser Doppler flowmeter, increased with infusion of pentoxifylline in members of both rat strains, but to a greater extent in SHRs than in normotensive animals. The mechanism of action appears to be decreased red blood cell rigidity which allows increased penetration of red blood cells into microvessels of the cochlea. SN - 0378-5955 UR - https://www.unboundmedicine.com/medline/citation/3209490/The_effects_of_pentoxifylline_on_cochlear_blood_flow_in_normotensive_and_spontaneously_hypertensive_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-5955(88)90059-7 DB - PRIME DP - Unbound Medicine ER -