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Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats.
Auton Neurosci. 2020 Feb 19; 225:102657.AN

Abstract

Cardiac microdialysis allows the assessment of cardiac efferent vagal nerve activity from myocardial interstitial acetylcholine (ACh) levels with minimal influence on the neural control of the heart; however, a total picture of the baroreflex-mediated myocardial interstitial ACh release including the threshold and saturation pressures has yet to be quantified. In eight anesthetized Wistar-Kyoto rats, we implanted microdialysis probes in the left ventricular free wall and measured the myocardial interstitial ACh release simultaneously with efferent sympathetic nerve activity (SNA) during a carotid sinus baroreceptor pressure input between 60 and 180 mm Hg. The baroreflex-mediated ACh release approximated a positive sigmoid curve, and its threshold and saturation pressures were not significantly different from those of an inverse sigmoid curve associated with the baroreflex-mediated SNA response (threshold: 94.3 ± 8.6 vs. 99.3 ± 6.0 mm Hg; saturation: 150.0 ± 10.3 vs. 158.8 ± 5.8 mm Hg). The sympathetic and vagal systems have certain levels of activities across most of the normal pressure range.

Authors+Show Affiliations

Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan. Electronic address: torukawa@ncvc.go.jp.Human Neurotransmitters Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.Department of Cardiac Physiology, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan.Department of Cardiac Physiology, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan.Department of Cardiac Physiology, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32097880

Citation

Kawada, Toru, et al. "Threshold and Saturation Pressures of Baroreflex-mediated Myocardial Interstitial Acetylcholine Release in Rats." Autonomic Neuroscience : Basic & Clinical, vol. 225, 2020, p. 102657.
Kawada T, Sata Y, Akiyama T, et al. Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. Auton Neurosci. 2020;225:102657.
Kawada, T., Sata, Y., Akiyama, T., Shimizu, S., Sonobe, T., Pearson, J. T., & Sugimachi, M. (2020). Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. Autonomic Neuroscience : Basic & Clinical, 225, 102657. https://doi.org/10.1016/j.autneu.2020.102657
Kawada T, et al. Threshold and Saturation Pressures of Baroreflex-mediated Myocardial Interstitial Acetylcholine Release in Rats. Auton Neurosci. 2020 Feb 19;225:102657. PubMed PMID: 32097880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. AU - Kawada,Toru, AU - Sata,Yusuke, AU - Akiyama,Tsuyoshi, AU - Shimizu,Shuji, AU - Sonobe,Takashi, AU - Pearson,James T, AU - Sugimachi,Masaru, Y1 - 2020/02/19/ PY - 2019/12/12/received PY - 2020/02/17/revised PY - 2020/02/18/accepted PY - 2020/2/26/pubmed PY - 2020/2/26/medline PY - 2020/2/26/entrez KW - Acetylcholine KW - Carotid sinus baroreflex KW - Open-loop analysis KW - Sympathetic nerve activity SP - 102657 EP - 102657 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 225 N2 - Cardiac microdialysis allows the assessment of cardiac efferent vagal nerve activity from myocardial interstitial acetylcholine (ACh) levels with minimal influence on the neural control of the heart; however, a total picture of the baroreflex-mediated myocardial interstitial ACh release including the threshold and saturation pressures has yet to be quantified. In eight anesthetized Wistar-Kyoto rats, we implanted microdialysis probes in the left ventricular free wall and measured the myocardial interstitial ACh release simultaneously with efferent sympathetic nerve activity (SNA) during a carotid sinus baroreceptor pressure input between 60 and 180 mm Hg. The baroreflex-mediated ACh release approximated a positive sigmoid curve, and its threshold and saturation pressures were not significantly different from those of an inverse sigmoid curve associated with the baroreflex-mediated SNA response (threshold: 94.3 ± 8.6 vs. 99.3 ± 6.0 mm Hg; saturation: 150.0 ± 10.3 vs. 158.8 ± 5.8 mm Hg). The sympathetic and vagal systems have certain levels of activities across most of the normal pressure range. SN - 1872-7484 UR - https://www.unboundmedicine.com/medline/citation/32097880/Threshold_and_saturation_pressures_of_baroreflex-mediated_myocardial_interstitial_acetylcholine_release_in_rats L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(19)30306-6 DB - PRIME DP - Unbound Medicine ER -
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