Tags

Type your tag names separated by a space and hit enter

Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice.
Int J Hepatol. 2020; 2020:9185361.IJ

Abstract

Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis. The present study was conducted to study the hepatoprotective activity of Cimetidine and Verapamil against the toxicity induced by paracetamol. In addition to the group receiving only distilled water or 300 mg/kg paracetamol additional groups were added treated with 150 mg/kg Cimetidine and Verapamil alone or both. The Liver function tests and histopathology revealed hepatotoxicity in the group receiving paracetamol (PCM) while normal parameters were observed in the groups receiving Cimetidine and Verapamil. Our results strongly suggested that Cimetidine and Verapamil possess hepatoprotective potential against paracetamol induced hepatotoxicity.

Authors+Show Affiliations

Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (CIRBS), International Islamic University Islamabad (IIUI), Islamabad, Pakistan.Department of Maxillofacial Surgery, Rehman College of Dentistry, Peshawar, Pakistan.Northwest School of Medicine, Phase-V Hayatabad, Peshawar, Pakistan.Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (CIRBS), International Islamic University Islamabad (IIUI), Islamabad, Pakistan.Department of Medicine, Khyber Teaching Hospital, Peshawar, Pakistan.Department of Pharmacology, National Institute of Health (NIH), Islamabad, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32099681

Citation

Danish, Lubna, et al. "Comparative Study of Protective Effect of Cimetidine and Verapamil On Paracetamol-Induced Hepatotoxicity in Mice." International Journal of Hepatology, vol. 2020, 2020, p. 9185361.
Danish L, Siddiq R, Jahan S, et al. Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice. Int J Hepatol. 2020;2020:9185361.
Danish, L., Siddiq, R., Jahan, S., Taneez, M., Khan, M., & Sandhu, M. (2020). Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice. International Journal of Hepatology, 2020, 9185361. https://doi.org/10.1155/2020/9185361
Danish L, et al. Comparative Study of Protective Effect of Cimetidine and Verapamil On Paracetamol-Induced Hepatotoxicity in Mice. Int J Hepatol. 2020;2020:9185361. PubMed PMID: 32099681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice. AU - Danish,Lubna, AU - Siddiq,Riffat, AU - Jahan,Sarwat, AU - Taneez,Mehwish, AU - Khan,Manzoor, AU - Sandhu,Marva, Y1 - 2020/01/23/ PY - 2019/10/11/received PY - 2019/11/25/accepted PY - 2020/2/27/entrez PY - 2020/2/27/pubmed PY - 2020/2/27/medline SP - 9185361 EP - 9185361 JF - International journal of hepatology JO - Int J Hepatol VL - 2020 N2 - Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis. The present study was conducted to study the hepatoprotective activity of Cimetidine and Verapamil against the toxicity induced by paracetamol. In addition to the group receiving only distilled water or 300 mg/kg paracetamol additional groups were added treated with 150 mg/kg Cimetidine and Verapamil alone or both. The Liver function tests and histopathology revealed hepatotoxicity in the group receiving paracetamol (PCM) while normal parameters were observed in the groups receiving Cimetidine and Verapamil. Our results strongly suggested that Cimetidine and Verapamil possess hepatoprotective potential against paracetamol induced hepatotoxicity. SN - 2090-3448 UR - https://www.unboundmedicine.com/medline/citation/32099681/Comparative_Study_of_Protective_Effect_of_Cimetidine_and_Verapamil_on_Paracetamol-Induced_Hepatotoxicity_in_Mice DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.