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Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2.
J Med Virol. 2020 06; 92(6):595-601.JM

Abstract

From the beginning of 2002 and 2012, severe respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) crossed the species barriers to infect humans, causing thousands of infections and hundreds of deaths, respectively. Currently, a novel coronavirus (SARS-CoV-2), which has become the cause of the outbreak of Coronavirus Disease 2019 (COVID-19), was discovered. Until 18 February 2020, there were 72 533 confirmed COVID-19 cases (including 10 644 severe cases) and 1872 deaths in China. SARS-CoV-2 is spreading among the public and causing substantial burden due to its human-to-human transmission. However, the intermediate host of SARS-CoV-2 is still unclear. Finding the possible intermediate host of SARS-CoV-2 is imperative to prevent further spread of the epidemic. In this study, we used systematic comparison and analysis to predict the interaction between the receptor-binding domain (RBD) of coronavirus spike protein and the host receptor, angiotensin-converting enzyme 2 (ACE2). The interaction between the key amino acids of S protein RBD and ACE2 indicated that, other than pangolins and snakes, as previously suggested, turtles (Chrysemys picta bellii, Chelonia mydas, and Pelodiscus sinensis) may act as the potential intermediate hosts transmitting SARS-CoV-2 to humans.

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Authors+Show Affiliations

Liu Z
Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China. State Key Laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan, China.
Xiao X
Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Wei X
Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Li J
Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Yang J
Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Tan H
Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Zhu J
Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Zhang Q
Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China. School of Public Health, Southern Medical University, Guangzhou, China.
Wu J
State Key Laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan, China. Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China.
Liu L
Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.

MeSH

Amino Acid SequenceAngiotensin-Converting Enzyme 2AnimalsBetacoronavirusBinding SitesCOVID-19ChinaChiropteraCoronavirus InfectionsEutheriaHumansModels, MolecularPandemicsPeptidyl-Dipeptidase APhylogenyPneumonia, ViralProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein Interaction Domains and MotifsProtein Interaction MappingReceptors, VirusSARS-CoV-2Sequence AlignmentSequence Homology, Amino AcidSnakesSpike Glycoprotein, CoronavirusTurtles

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32100877

Citation

Liu, Zhixin, et al. "Composition and Divergence of Coronavirus Spike Proteins and Host ACE2 Receptors Predict Potential Intermediate Hosts of SARS-CoV-2." Journal of Medical Virology, vol. 92, no. 6, 2020, pp. 595-601.
Liu Z, Xiao X, Wei X, et al. Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. J Med Virol. 2020;92(6):595-601.
Liu, Z., Xiao, X., Wei, X., Li, J., Yang, J., Tan, H., Zhu, J., Zhang, Q., Wu, J., & Liu, L. (2020). Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. Journal of Medical Virology, 92(6), 595-601. https://doi.org/10.1002/jmv.25726
Liu Z, et al. Composition and Divergence of Coronavirus Spike Proteins and Host ACE2 Receptors Predict Potential Intermediate Hosts of SARS-CoV-2. J Med Virol. 2020;92(6):595-601. PubMed PMID: 32100877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. AU - Liu,Zhixin, AU - Xiao,Xiao, AU - Wei,Xiuli, AU - Li,Jian, AU - Yang,Jing, AU - Tan,Huabing, AU - Zhu,Jianyong, AU - Zhang,Qiwei, AU - Wu,Jianguo, AU - Liu,Long, Y1 - 2020/03/11/ PY - 2020/02/19/received PY - 2020/02/24/accepted PY - 2020/2/27/pubmed PY - 2020/7/1/medline PY - 2020/2/27/entrez KW - Coronavirus Disease 2019 (COVID-19) KW - SARS-CoV-2 KW - SARS-CoV-2 spike protein (S) KW - angiotensin-converting enzyme 2 (ACE2) KW - receptor-binding domain (RBD) of coronavirus SP - 595 EP - 601 JF - Journal of medical virology JO - J Med Virol VL - 92 IS - 6 N2 - From the beginning of 2002 and 2012, severe respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) crossed the species barriers to infect humans, causing thousands of infections and hundreds of deaths, respectively. Currently, a novel coronavirus (SARS-CoV-2), which has become the cause of the outbreak of Coronavirus Disease 2019 (COVID-19), was discovered. Until 18 February 2020, there were 72 533 confirmed COVID-19 cases (including 10 644 severe cases) and 1872 deaths in China. SARS-CoV-2 is spreading among the public and causing substantial burden due to its human-to-human transmission. However, the intermediate host of SARS-CoV-2 is still unclear. Finding the possible intermediate host of SARS-CoV-2 is imperative to prevent further spread of the epidemic. In this study, we used systematic comparison and analysis to predict the interaction between the receptor-binding domain (RBD) of coronavirus spike protein and the host receptor, angiotensin-converting enzyme 2 (ACE2). The interaction between the key amino acids of S protein RBD and ACE2 indicated that, other than pangolins and snakes, as previously suggested, turtles (Chrysemys picta bellii, Chelonia mydas, and Pelodiscus sinensis) may act as the potential intermediate hosts transmitting SARS-CoV-2 to humans. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/32100877/Composition_and_divergence_of_coronavirus_spike_proteins_and_host_ACE2_receptors_predict_potential_intermediate_hosts_of_SARS_CoV_2_ L2 - https://doi.org/10.1002/jmv.25726 DB - PRIME DP - Unbound Medicine ER -