Citation
Chen, Weilie, et al. "Detectable 2019-nCoV Viral RNA in Blood Is a Strong Indicator for the Further Clinical Severity." Emerging Microbes & Infections, vol. 9, no. 1, 2020, pp. 469-473.
Chen W, Lan Y, Yuan X, et al. Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerg Microbes Infect. 2020;9(1):469-473.
Chen, W., Lan, Y., Yuan, X., Deng, X., Li, Y., Cai, X., Li, L., He, R., Tan, Y., Deng, X., Gao, M., Tang, G., Zhao, L., Wang, J., Fan, Q., Wen, C., Tong, Y., Tang, Y., Hu, F., ... Tang, X. (2020). Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerging Microbes & Infections, 9(1), 469-473. https://doi.org/10.1080/22221751.2020.1732837
Chen W, et al. Detectable 2019-nCoV Viral RNA in Blood Is a Strong Indicator for the Further Clinical Severity. Emerg Microbes Infect. 2020;9(1):469-473. PubMed PMID: 32102625.
TY - JOUR
T1 - Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.
AU - Chen,Weilie,
AU - Lan,Yun,
AU - Yuan,Xiaozhen,
AU - Deng,Xilong,
AU - Li,Yueping,
AU - Cai,Xiaoli,
AU - Li,Liya,
AU - He,Ruiying,
AU - Tan,Yizhou,
AU - Deng,Xizi,
AU - Gao,Ming,
AU - Tang,Guofang,
AU - Zhao,Lingzhai,
AU - Wang,Jinlin,
AU - Fan,Qinghong,
AU - Wen,Chunyan,
AU - Tong,Yuwei,
AU - Tang,Yangbo,
AU - Hu,Fengyu,
AU - Li,Feng,
AU - Tang,Xiaoping,
Y1 - 2020/02/26/
PY - 2020/2/28/entrez
PY - 2020/2/28/pubmed
PY - 2020/3/20/medline
KW - 2019-ncov
KW - anal swab
KW - blood viral RNA
KW - laboratory test
KW - pharyngeal swab
SP - 469
EP - 473
JF - Emerging microbes & infections
JO - Emerg Microbes Infect
VL - 9
IS - 1
N2 - The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.
SN - 2222-1751
UR - https://www.unboundmedicine.com/medline/citation/32102625/full_citation
L2 - https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1732837
DB - PRIME
DP - Unbound Medicine
ER -