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Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.
Emerg Microbes Infect. 2020; 9(1):469-473.EM

Abstract

The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.

Authors+Show Affiliations

Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.

Pub Type(s)

Letter

Language

eng

PubMed ID

32102625

Citation

Chen, Weilie, et al. "Detectable 2019-nCoV Viral RNA in Blood Is a Strong Indicator for the Further Clinical Severity." Emerging Microbes & Infections, vol. 9, no. 1, 2020, pp. 469-473.
Chen W, Lan Y, Yuan X, et al. Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerg Microbes Infect. 2020;9(1):469-473.
Chen, W., Lan, Y., Yuan, X., Deng, X., Li, Y., Cai, X., Li, L., He, R., Tan, Y., Deng, X., Gao, M., Tang, G., Zhao, L., Wang, J., Fan, Q., Wen, C., Tong, Y., Tang, Y., Hu, F., ... Tang, X. (2020). Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerging Microbes & Infections, 9(1), 469-473. https://doi.org/10.1080/22221751.2020.1732837
Chen W, et al. Detectable 2019-nCoV Viral RNA in Blood Is a Strong Indicator for the Further Clinical Severity. Emerg Microbes Infect. 2020;9(1):469-473. PubMed PMID: 32102625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. AU - Chen,Weilie, AU - Lan,Yun, AU - Yuan,Xiaozhen, AU - Deng,Xilong, AU - Li,Yueping, AU - Cai,Xiaoli, AU - Li,Liya, AU - He,Ruiying, AU - Tan,Yizhou, AU - Deng,Xizi, AU - Gao,Ming, AU - Tang,Guofang, AU - Zhao,Lingzhai, AU - Wang,Jinlin, AU - Fan,Qinghong, AU - Wen,Chunyan, AU - Tong,Yuwei, AU - Tang,Yangbo, AU - Hu,Fengyu, AU - Li,Feng, AU - Tang,Xiaoping, Y1 - 2020/02/26/ PY - 2020/2/28/entrez PY - 2020/2/28/pubmed PY - 2020/3/20/medline KW - 2019-ncov KW - anal swab KW - blood viral RNA KW - laboratory test KW - pharyngeal swab SP - 469 EP - 473 JF - Emerging microbes & infections JO - Emerg Microbes Infect VL - 9 IS - 1 N2 - The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites. SN - 2222-1751 UR - https://www.unboundmedicine.com/medline/citation/32102625/full_citation L2 - https://www.tandfonline.com/doi/full/10.1080/22221751.2020.1732837 DB - PRIME DP - Unbound Medicine ER -