TY - JOUR T1 - Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. AU - Chen,Weilie, AU - Lan,Yun, AU - Yuan,Xiaozhen, AU - Deng,Xilong, AU - Li,Yueping, AU - Cai,Xiaoli, AU - Li,Liya, AU - He,Ruiying, AU - Tan,Yizhou, AU - Deng,Xizi, AU - Gao,Ming, AU - Tang,Guofang, AU - Zhao,Lingzhai, AU - Wang,Jinlin, AU - Fan,Qinghong, AU - Wen,Chunyan, AU - Tong,Yuwei, AU - Tang,Yangbo, AU - Hu,Fengyu, AU - Li,Feng, AU - Tang,Xiaoping, Y1 - 2020/02/26/ PY - 2020/2/28/entrez PY - 2020/2/28/pubmed PY - 2020/3/20/medline KW - 2019-ncov KW - anal swab KW - blood viral RNA KW - laboratory test KW - pharyngeal swab SP - 469 EP - 473 JF - Emerging microbes & infections JO - Emerg Microbes Infect VL - 9 IS - 1 N2 - The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites. SN - 2222-1751 UR - https://www.unboundmedicine.com/medline/citation/32102625/full_citation DB - PRIME DP - Unbound Medicine ER -