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Caffeine and its main targets of colorectal cancer.
World J Gastrointest Oncol. 2020 Feb 15; 12(2):149-172.WJ

Abstract

Caffeine is a purine alkaloid and is widely consumed in coffee, soda, tea, chocolate and energy drinks. To date, a growing number of studies have indicated that caffeine is associated with many diseases including colorectal cancer. Caffeine exerts its biological activity through binding to adenosine receptors, inhibiting phosphodiesterases, sensitizing calcium channels, antagonizing gamma-aminobutyric acid receptors and stimulating adrenal hormones. Some studies have indicated that caffeine can interact with signaling pathways such as transforming growth factor β, phosphoinositide-3-kinase/AKT/mammalian target of rapamycin and mitogen-activated protein kinase pathways through which caffeine can play an important role in colorectal cancer pathogenesis, metastasis and prognosis. Moreover, caffeine can act as a general antioxidant that protects cells from oxidative stress and also as a regulatory factor of the cell cycle that modulates the DNA repair system. Additionally, as for intestinal homeostasis, through the interaction with receptors and cytokines, caffeine can modulate the immune system mediating its effects on T lymphocytes, B lymphocytes, natural killer cells and macrophages. Furthermore, caffeine can not only directly inhibit species in the gut microbiome, such as Escherichia coli and Candida albicans but also can indirectly exert inhibition by increasing the effects of other antimicrobial drugs. This review summarizes the association between colorectal cancer and caffeine that is being currently studied.

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Authors+Show Affiliations

Cui WQ
Department of Neurology, Shengjing Hospital, Affiliated Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
Wang ST
Department of Cardiovascular Ultrasound, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Pan D
Department of Geriatrics, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Chang B
Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Sang LX
Department of Geriatrics, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. sanglixuan2008@163.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32104547

Citation

Cui, Wen-Qi, et al. "Caffeine and Its Main Targets of Colorectal Cancer." World Journal of Gastrointestinal Oncology, vol. 12, no. 2, 2020, pp. 149-172.
Cui WQ, Wang ST, Pan D, et al. Caffeine and its main targets of colorectal cancer. World J Gastrointest Oncol. 2020;12(2):149-172.
Cui, W. Q., Wang, S. T., Pan, D., Chang, B., & Sang, L. X. (2020). Caffeine and its main targets of colorectal cancer. World Journal of Gastrointestinal Oncology, 12(2), 149-172. https://doi.org/10.4251/wjgo.v12.i2.149
Cui WQ, et al. Caffeine and Its Main Targets of Colorectal Cancer. World J Gastrointest Oncol. 2020 Feb 15;12(2):149-172. PubMed PMID: 32104547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine and its main targets of colorectal cancer. AU - Cui,Wen-Qi, AU - Wang,Shi-Tong, AU - Pan,Dan, AU - Chang,Bing, AU - Sang,Li-Xuan, PY - 2019/09/12/received PY - 2019/10/25/revised PY - 2019/11/13/accepted PY - 2020/2/28/entrez PY - 2020/2/28/pubmed PY - 2020/2/28/medline KW - Caffeine KW - Cell cycle KW - Colorectal cancer KW - Epidemiology KW - Immune response KW - Signaling pathway SP - 149 EP - 172 JF - World journal of gastrointestinal oncology JO - World J Gastrointest Oncol VL - 12 IS - 2 N2 - Caffeine is a purine alkaloid and is widely consumed in coffee, soda, tea, chocolate and energy drinks. To date, a growing number of studies have indicated that caffeine is associated with many diseases including colorectal cancer. Caffeine exerts its biological activity through binding to adenosine receptors, inhibiting phosphodiesterases, sensitizing calcium channels, antagonizing gamma-aminobutyric acid receptors and stimulating adrenal hormones. Some studies have indicated that caffeine can interact with signaling pathways such as transforming growth factor β, phosphoinositide-3-kinase/AKT/mammalian target of rapamycin and mitogen-activated protein kinase pathways through which caffeine can play an important role in colorectal cancer pathogenesis, metastasis and prognosis. Moreover, caffeine can act as a general antioxidant that protects cells from oxidative stress and also as a regulatory factor of the cell cycle that modulates the DNA repair system. Additionally, as for intestinal homeostasis, through the interaction with receptors and cytokines, caffeine can modulate the immune system mediating its effects on T lymphocytes, B lymphocytes, natural killer cells and macrophages. Furthermore, caffeine can not only directly inhibit species in the gut microbiome, such as Escherichia coli and Candida albicans but also can indirectly exert inhibition by increasing the effects of other antimicrobial drugs. This review summarizes the association between colorectal cancer and caffeine that is being currently studied. SN - 1948-5204 UR - https://www.unboundmedicine.com/medline/citation/32104547/Caffeine_and_its_main_targets_of_colorectal_cancer_ DB - PRIME DP - Unbound Medicine ER -