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The cell biology of the retinal pigment epithelium.
Prog Retin Eye Res. 2020 Feb 24 [Online ahead of print]PR

Abstract

The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness. Decades of research have yielded valuable insight into the cell biology of the RPE. In recent years, new technologies such as live-cell imaging have resulted in major advancement in our understanding of areas such as the daily phagocytosis and clearance of photoreceptor outer segment tips, autophagy, endolysosome function, and the metabolic interplay between the RPE and photoreceptors. In this review, we aim to integrate these studies with an emphasis on appropriate models and techniques to investigate RPE cell biology and metabolism, and discuss how RPE cell biology informs our understanding of retinal disease.

Authors+Show Affiliations

Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.Department of Ophthalmology and Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.Department of Ophthalmology and Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: dswilliams@ucla.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32105772

Citation

Lakkaraju, Aparna, et al. "The Cell Biology of the Retinal Pigment Epithelium." Progress in Retinal and Eye Research, 2020, p. 100846.
Lakkaraju A, Umapathy A, Tan LX, et al. The cell biology of the retinal pigment epithelium. Prog Retin Eye Res. 2020.
Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020). The cell biology of the retinal pigment epithelium. Progress in Retinal and Eye Research, 100846. https://doi.org/10.1016/j.preteyeres.2020.100846
Lakkaraju A, et al. The Cell Biology of the Retinal Pigment Epithelium. Prog Retin Eye Res. 2020 Feb 24;100846. PubMed PMID: 32105772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cell biology of the retinal pigment epithelium. AU - Lakkaraju,Aparna, AU - Umapathy,Ankita, AU - Tan,Li Xuan, AU - Daniele,Lauren, AU - Philp,Nancy J, AU - Boesze-Battaglia,Kathleen, AU - Williams,David S, Y1 - 2020/02/24/ PY - 2019/10/22/received PY - 2020/02/19/revised PY - 2020/02/23/accepted PY - 2020/2/28/pubmed PY - 2020/2/28/medline PY - 2020/2/28/entrez KW - Autophagy KW - Endosomes KW - Lysosomes KW - Metabolism KW - Organelles KW - Phagocytosis KW - Phagosome maturation SP - 100846 EP - 100846 JF - Progress in retinal and eye research JO - Prog Retin Eye Res N2 - The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness. Decades of research have yielded valuable insight into the cell biology of the RPE. In recent years, new technologies such as live-cell imaging have resulted in major advancement in our understanding of areas such as the daily phagocytosis and clearance of photoreceptor outer segment tips, autophagy, endolysosome function, and the metabolic interplay between the RPE and photoreceptors. In this review, we aim to integrate these studies with an emphasis on appropriate models and techniques to investigate RPE cell biology and metabolism, and discuss how RPE cell biology informs our understanding of retinal disease. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/32105772/The_cell_biology_of_the_retinal_pigment_epithelium L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(20)30018-5 DB - PRIME DP - Unbound Medicine ER -
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